Iain Chalmers

2023

Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes

Padalino, G., Celatka, C., Rienhoff Jr., H. Y., Kalin, J. H., Cole, P. A., Lassalle, D., Forde-Thomas, J., Chalmers, I., Brancale, A., Grunau, C. & Hoffmann, K., 30 Maw 2023, Yn: Wellcome Open Research. 8, 146, 29 t., 146.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

1 Dyfyniad (Scopus)

48 Wedi eu Llwytho i Lawr (Pure)

Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like expression in Schistosoma haematobium and Schistosoma mansoni infection

Oettle, R. C., Dickinson, H. A., Fitzsimmons, C. M., Sacko, M., Tukahebwa, E. M., Chalmers, I. W., Wilson, S. & Loke, P. (Golygydd), 25 Mai 2023, Yn: PLoS Pathogens. 19, 5, 20 t., e1011037.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

2 Dyfyniadau (Scopus)

93 Wedi eu Llwytho i Lawr (Pure)

Special considerations for studies of extracellular vesicles from parasitic helminths: A community-led roadmap to increase rigour and reproducibility

White, R., Sotillo, J., Ancarola, M. E., Borup, A., Boysen, A. T., Brindley, P. J., Buzás, E. I., Cavallero, S., Chaiyadet, S., Chalmers, I. W., Cucher, M. A., Dagenais, M., Davis, C. N., Devaney, E., Duque-Correa, M. A., Eichenberger, R. M., Fontenla, S., Gasan, T. A., Hokke, C. H. & Kosanovic, M. & 22 eraill, Kuipers, M. E., Laha, T., Loukas, A., Maizels, R. M., Marcilla, A., Mazanec, H., Morphew, R. M., Neophytou, K., Nguyen, L. T., Nolte-'t Hoen, E., Povelones, M., Robinson, M. W., Rojas, A., Schabussova, I., Smits, H. H., Sungpradit, S., Tritten, L., Whitehead, B., Zakeri, A., Nejsum, P., Buck, A. H. & Hoffmann, K. F., 05 Ion 2023, Yn: Journal of Extracellular Vesicles. 12, 1, 16 t., 12298.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

25 Dyfyniadau (Scopus)

77 Wedi eu Llwytho i Lawr (Pure)

2022

In silico characterisation of the complete Ly6 protein family in Fasciola gigantica supported through transcriptomics of the newly-excysted juveniles

Davey, S. D., Chalmers, I. W., Fernandez-Fuentes, N., Swain, M. T., Smith, D., Abbas Abidi, S. M., Saifullah, M. K., Raman, M., Ravikumar, G., McVeigh, P., Maule, A. G., Brophy, P. M. & Morphew, R. M., 17 Ion 2022, Yn: Molecular Omics. 18, 1, t. 45-56 12 t.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

5 Dyfyniadau (Scopus)

75 Wedi eu Llwytho i Lawr (Pure)

Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production

Hulme, B. J., Geyer, K. K., Forde-Thomas, J. E., Padalino, G., Phillips, D. W., Ittiprasert, W., Karinshak, S. E., Mann, V. H., Chalmers, I. W., Brindley, P. J., Hokke, C. H. & Hoffmann, K. F., 13 Ion 2022, Yn: PLoS Pathogens. 18, 1, 35 t., e1009828.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

19 Dyfyniadau (Scopus)

110 Wedi eu Llwytho i Lawr (Pure)

2021

Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation

Padalino, G., El-Sakkary, N., Liu, L. J., Liu, C., Harte, D. S. G., Barnes, R. E., Sayers, E., Forde-Thomas, J., Whiteland, H., Bassetto, M., Ferla, S., Johnson, G., Jones, A. T., Caffrey, C. R., Chalmers, I., Brancale, A. & Hoffmann, K. F., 15 Rhag 2021, Yn: European Journal of Medicinal Chemistry. 226, 19 t., 113823.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

7 Dyfyniadau (Scopus)

145 Wedi eu Llwytho i Lawr (Pure)

Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae

Gasan, T. A., Kuipers, M. E., Roberts, G. H., Padalino, G., Forde-Thomas, J. E., Wilson, S., Wawrzyniak, J., Tukahebwa, E. M., Hoffmann, K. F. & Chalmers, I. W., 18 Tach 2021, Yn: PLoS Neglected Tropical Diseases. 15, 11, e0009981.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

6 Dyfyniadau (Scopus)

Schistosoma mansoni venom allergen-like protein 6 (SmVAL6) maintains tegumental barrier function

Perally, S., Geyer, K. K., Farani, P. S. G., Chalmers, I. W., Fernandez-Fuentes, N., Maskell, D. R., Hulme, B. J., Forde-Thomas, J., Phillips, D., Farias, L. P., Collins, J. J. & Hoffmann, K. F., 01 Maw 2021, Yn: International Journal for Parasitology. 51, 4, t. 251-261 11 t.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

6 Dyfyniadau (Scopus)

89 Wedi eu Llwytho i Lawr (Pure)

2020

Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities

Padalino, G., Chalmers, I. W., Brancale, A. & Hoffmann, K. F., 13 Tach 2020, Yn: Wellcome Open Research. 5, 37 t., 169.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

6 Dyfyniadau (Scopus)

69 Wedi eu Llwytho i Lawr (Pure)

2019

Schistosoma mansoni venom allergen-like proteins: Phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity

Farias, L. P., Chalmers, I. W., Perally, S., Rofatto, H. K., Jackson, C. J., Brown, M., Khouri, M. I., Barbosa, M. M. F., Hensbergen, P. J., Hokke, C. H., Leite, L. C. C. & Hoffmann, K. F., 01 Gorff 2019, Yn: International Journal for Parasitology. 49, 8, t. 593-599 7 t.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

8 Dyfyniadau (Scopus)

168 Wedi eu Llwytho i Lawr (Pure)

The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

Whatley, K., Padalino, G., Whiteland, H., Geyer, K. K., Hulme, B. J., Chalmers, I., Forde-Thomas, J., Ferla, S., Brancale, A. & Hoffmann, K., 15 Tach 2019, Yn: PLoS Neglected Tropical Diseases. 13, 11, 24 t., e0007693.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

21 Dyfyniadau (Scopus)

223 Wedi eu Llwytho i Lawr (Pure)

2018

Antibody Responses to Schistosoma mansoni Schistosomula Antigens

Egesa, M., Lubyayi, L., Jones, F. M., van Diepen, A., Chalmers, I., Tukahebwa, E. M., Bagaya, B. S., Hokke, C. H., Hoffmann, K., Dunne, D. W., Elliot, A. M., Yazdanbakhsh, M., Wilson, S. & Cose, S., 28 Tach 2018, Yn: Parasite Immunology. 40, 12, e12591.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

7 Dyfyniadau (Scopus)

154 Wedi eu Llwytho i Lawr (Pure)

Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni

Padalino, G., Ferla, S., Brancale, A., Chalmers, I. & Hoffmann, K., 31 Rhag 2018, Yn: International Journal for Parasitology: Drugs and Drug Resistance. 8, 3, t. 559-570 12 t.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

27 Dyfyniadau (Scopus)

183 Wedi eu Llwytho i Lawr (Pure)

Schistosoma mansoni schistosomula antigens induce Th1/Pro-inflammatory cytokine responses

Egesa, M., Lubyayi, L., Tukahebwa, E. M., Bagaya, B. S., Chalmers, I., Wilson, S., Hokke, C. H., Hoffmann, K., Dunne, D. W., Yazdanbakhsh, M., Labuda, L. A. & Cose, S., 28 Tach 2018, Yn: Parasite Immunology. 40, 12, e12592.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

17 Dyfyniadau (Scopus)

133 Wedi eu Llwytho i Lawr (Pure)

2017

The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni

Geyer, K., Niazi, U., Duval, D., Cosseau, C., Tomlinson, C., Chalmers, I., Swain, M., Cutress, D., Bickham-Wright, U., Munshi, S. E., Grunau, C., Yoshino, T. P. & Hoffmann, K., 16 Mai 2017, Yn: PLoS Neglected Tropical Diseases. 11, 5, 29 t., e0005246.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

35 Dyfyniadau (Scopus)

209 Wedi eu Llwytho i Lawr (Pure)

Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Adema, C. M., Hillier, L. W., Jones, C. S., Loker, E. S., Knight, M., Minx, P., Oliveira, G., Raghavan, N., Shedlock, A., do Amaral, L. R., Arican-Goktas, H. D., Assis, J. G., Baba, E. H., Baron, O. L., Bayne, C. J., Bickham-Wright, U., Biggar, K. K., Blouin, M., Bonning, B. C. & Botka, C. & 97 eraill, Bridger, J. M., Buckley, K. M., Buddenborg, S. K., Lima Caldeira, R., Carleton, J., Carvalho, O. S., Castillo, M. G., Chalmers, I. W., Christensens, M., Clifton, S., Cosseau, C., Coustau, C., Cripps, R. M., Cuesta-Astroz, Y., Cummins, S. F., Di Stephano, L., Dinguirard, N., Duval, D., Emrich, S., Feschotte, C., Feyereisen, R., Fitzgerald, P., Fronick, C., Fulton, L., Galinier, R., Gava, S. G., Geusz, M., Geyer, K. K., Giraldo-Calderón, G. I., de Souza Gomes, M., Gordy, M. A., Gourbal, B., Grunau, C., Hanington, P. C., Hoffmann, K. F., Hughes, D., Humphries, J., Jackson, D. J., Jannotti-Passos, L. K., De Jesus Jeremias, W., Jobling, S., Kamel, B., Kapusta, A., Kaur, S., Koene, J. M., Kohn, A. B., Lawson, D., Lawton, S. P., Liang, D., Limpanont, Y., Liu, S., Lockyer, A. E., Lovato, T. L., Ludolf, F., Magrini, V., Mcmanus, D. P., Medina, M., Misra, M., Mitta, G., Mkoji, G. M., Montague, M. J., Montelongo, C., Moroz, L. L., Munoz-Torres, M. C., Niazi, U., Noble, L. R., Oliveira, F. S., Pais, F. S., Papenfuss, A. T., Peace, R., Pena, J. J., Pila, E. A., Quelais, T., Raney, B. J., Rast, J. P., Rollinson, D., Rosse, I. C., Rotgans, B., Routledge, E. J., Ryan, K. M., Scholte, L. L. S., Storey, K. B., Swain, M., Tennessen, J. A., Tomlinson, C., Trujillo, D. L., Volpi, E. V., Walker, A. J., Wang, T., Wannaporn, I., Warren, W. C., Wu, X.-J., Yoshino, T. P., Yusuf, M., Zhang, S.-M., Zhao, M. & Wilson, R. K., 16 Mai 2017, Yn: Nature Communications. 8, t. 15451 15451.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

193 Dyfyniadau (Scopus)

169 Wedi eu Llwytho i Lawr (Pure)

2015

Drug-Induced Exposure of Schistosoma mansoni Antigens SmCD59a and SmKK7

Reimers, N., Homann, A., Höschler, B., Langhans, K., Wilson, R. A., Pierrot, C., Khalife, J., Grevelding, C. G., Chalmers, I. W., Yazdanbakhsh, M., Hoffmann, K. F., Hokke, C. H., Haas, H. & Schramm, G., 16 Maw 2015, Yn: PLoS Neglected Tropical Diseases. 9, 3, e0003593.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

26 Dyfyniadau (Scopus)

166 Wedi eu Llwytho i Lawr (Pure)

Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment

Chalmers, I. W., Fitzsimmons, C. M., Brown, M., Pierrot, C., Jones, F. M., Wawrzyniak, J. M., Fernandez-Fuentes, N., Tukahebwa, E. M., Dunne, D. W., Khalife, J. & Hoffmann, K. F., Gorff 2015, Yn: PLoS Neglected Tropical Diseases. 9, 7, t. e0003920 e0003920.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

14 Dyfyniadau (Scopus)

198 Wedi eu Llwytho i Lawr (Pure)

Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection

Farnell, E. J., Tyagi, N., Ryan, S., Chalmers, I. W., Pinot de Moira, A., Jones, F. M., Wawrzyniak, J., Fitzsimmons, C. M., Tukahebwa, E. M., Furnham, N., Maizels, R. M. & Dunne, D. W., 03 Chwef 2015, Yn: Frontiers in Immunology. 6, t. 26

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

22 Dyfyniadau (Scopus)

149 Wedi eu Llwytho i Lawr (Pure)

2014

Excreted/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expression

Yoshino, T. P., Brown, M., Wu, X.-J., Jackson, C. J., Ocadiz-Ruiz, R., Chalmers, I. W., Kolb, M., Hokke, C. H. & Hoffmann, K. F., Gorff 2014, Yn: International Journal for Parasitology. 44, 8, t. 551-563 13 t.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

37 Dyfyniadau (Scopus)

309 Wedi eu Llwytho i Lawr (Pure)

2013

Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes

Geyer, K. K., Chalmers, I. W., MacKintosh, N. D., Hirst, J. E., Geoghegan, R., Badets, M., Brophy, P. M., Brehm, K. & Hoffmann, K. F., 09 Gorff 2013, Yn: BMC Genomics. 14, 1, 462.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

32 Dyfyniadau (Scopus)

188 Wedi eu Llwytho i Lawr (Pure)

2012

Platyhelminth venom allergen-like (VAL) proteins: revealing structural diversity, class specific features and biological associations across the phylum

Chalmers, I. W. & Hoffmann, K. F., 02 Mai 2012, Yn: Parasitology. 139, 10, t. 1231-1245 15 t.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

40 Dyfyniadau (Scopus)

The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses

Fitzsimmons, C. M., Jones, F. M., Stearn, A., Chalmers, I. W., Hoffmann, K. F., Wawrzyniak, J., Wilson, S., Kabatereine, N. B. & Dunne, D. W., 03 Ebr 2012, Yn: PLoS Neglected Tropical Diseases. 6, 4, e1593.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

65 Dyfyniadau (Scopus)

131 Wedi eu Llwytho i Lawr (Pure)

2011

Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni

Geyer, K. K., Rodríguez-López, C. M., Hoffmann, K. F., Chalmers, I. W., Munshi, S. E., Truscott, M., Heald, J. K., Wilkinson, M. J. & Hoffmann, K. F., 09 Awst 2011, Yn: Nature Communications. 2, 424.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

93 Dyfyniadau (Scopus)

2010

Development and Validation of a Quantitative, High-Throughput, Fluorescent-Based Bioassay to Detect Schistosoma Viability

Peak, E., Chalmers, I. W. & Hoffmann, K. F., 27 Gorff 2010, Yn: PLoS Neglected Tropical Diseases. 4, 7, e759.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

87 Dyfyniadau (Scopus)

157 Wedi eu Llwytho i Lawr (Pure)

2009

Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses

Fitzpatrick, J. M., Peak, E., Perally, S., Chalmers, I. W., Barrett, J., Yoshino, T. P., Ivens, A. C. & Hoffmann, K. F., 03 Tach 2009, Yn: PLoS Neglected Tropical Diseases. 3, 11, e543.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

105 Dyfyniadau (Scopus)

144 Wedi eu Llwytho i Lawr (Pure)

Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity

Fitzpatrick, J. M., Fuentes, J. M., Chalmers, I. W., Wynn, T. A., Modolell, M., Hoffmann, K. F. & Hesse, M., Chwef 2009, Yn: International Journal for Parasitology. 39, 3, t. 267-279 13 t.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

17 Dyfyniadau (Scopus)

2008

Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family

Chalmers, I. W., McArdle, A. J., Coulson, R. M. R., Wagner, M. A., Schmid, R., Hirai, H. & Hoffmann, K. F., 23 Chwef 2008, Yn: BMC Genomics. 9, 89.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored

Ffeil

102 Dyfyniadau (Scopus)

170 Wedi eu Llwytho i Lawr (Pure)

2005

Molecular characterization of omega-1: A hepatotoxic ribonuclease from Schistosoma mansoni eggs

Fitzsimmons, C. M., Schramm, G., Jones, F. M., Chalmers, I. W., Hoffmann, K. F., Grevelding, C. G., Wuhrer, M., Hokke, C. H., Haas, H., Doenhoff, M. J. & Dunne, D. W., Tach 2005, Yn: Molecular and Biochemical Parasitology. 144, 1, t. 123-127 5 t.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

77 Dyfyniadau (Scopus)

Iain Chalmers

Allbwn ymchwil

Canlyniadau chwilio