Proffil personol
Dysgu
My Teaching at the DLS and School of Veterinary Science focuses on cell and molecular biology, cancer, biotechnology, genomics and infectious diseases.
Scheme leader for the MRes in Parasite Control. Module Coordinator for MSc Dissertation (BRM3560), Cell and Cancer Biology (BR25920) and Hot Topics in Parasite Control (BRM0920). Contribute to teaching in several other modules including: Molecular Biology Skills (BR12210), Study and Communication Skills (BR12410), One Health Microbiology (BR26520), Biotechnology (35520), Molecular Biology of Development (BR36020), Parasitology (BR33820), Research Project (BR36440), Infection & Immunity (BRM1620), Current Topics in Biotechnology (BRM0720), Livestock Nutrition (BRM0320), Research Methods in the Biosciences (BRM6420), MBiol Research Project (BRM2860), MRes Dissertation (BRM6060). Tutor Veterinary Bioscience and taught MSc scheme students; previously tutored Biology, Microbiology, Microbiology & Zoology degree scheme undergraduate students.
Current Postgraduate Students: Abigail Webb (Aberystwyth University PhD Studentship), Justyna Nalepa Gracar (KESS PhD Toxoplasma Reference Unit, Public Health Wales); Helen Laird (with Queens University, Belfast, DTP PhD studentship); Hafsat Alabere (MRes); Abhijit Nikam (MRes); Brandon Wroblewski (MBiol).
Previous Postgraduate Students: Arthur Morris (KESS PhD); Adrian Horton (TSB PhD studentship with 2SFG Ltd as lead partner); Laura Lyons (EU BEACON PhD studentship); Simon Cameron (Aberystwyth University PhD Studentship); James Doonan (with Bangor University, Forest Research PhD studentship); Shane Collete (Self funded MPHil); Jenna Alexander (KESS MPhil studentship with Cryptosporidium Reference Unit, Public Health Wales); Julia Tello Velamazan (KESS MPhil studentship with Natural Feeds and Fertilizers Ltd); Szymon Callus (KESS MPhil Studentship); Samson Baolgun (MRes); Harry Champion (MBiol); Adriana Szczerepa (MBiol).
Proffil
As a Senior Lecturer in Microbial Genomics at the Department of Life Science (DLS) and School of Veterinary Science, and an Admissions Tutor for DLS Biology schemes, I have a combined research and teaching role. My research focuses on the application of single molecule genomics (SMG), next generation sequencing (NGS) techniques to study microbial populations and characterise pathogens, in particular protozoan parasites.
I am a parasitologist / microbiologist experienced in SMG and NGS techniques. After degrees in Microbiology (BSC Hons) at Bristol University and Medical Microbiology (MSc & Diploma) at the London School of Hygiene and Tropical Medicine, I did a PhD at the Medical Research Centre National Institute for Medical Research on the characterisation and biosynthesis of a malaria vaccine target: Merozoite Surface Protein 7 in Plasmodium falciparum merozoites. After my PhD I did several post-docs at the MRC Laboratory of Molecular Biology (2000-2007) and the University of Cambridge (2007-2009). At the MRC-LMB, I ran the HAPPY genome mapping project as part of the international Dictyostelium discoideum genome consortium (see Nature papers), I also ran several R&D projects with the Sanger, TIGR, and Universities of Glasgow and Oxford. At the University of Cambridge, I was based in Jim Haseloff's laboratory at Plant Sciences, and developed an interest in synthetic biology; whilst David Baulcombe developed my interest in NGS which lead to collaborations with: Jim Ajioka (Pathology) and Carolina Marcano (Illumina) to characterise Campylobacter bacteriophage genomes; Gareth Bloomfield and Rob Kay (MRC-LMB) on D. discoideum phenotypic mutants (see E Life paper), Sarah Covshoff and Julian Hibberd on Echinochloa and Rice transcriptomics (see Plant Physiology paper).
Diddordebau ymchwil
Key words: Anopheles, Campylobacter, Cryptosporidium, Diagnostics, Dictyostelium, Enteric Pathogens, Eimeria, Enterococcus, Honey bee diseases, Host-Pathogen interactions, Illumina, Insect microbiomes, Malaria, Meta-genomics, Meta-transcriptomes, Next Generation Sequencing, Parasites, Phage, Plasmodium, Rhodococcus, Sequencing, Single molecule genomics, Toxoplasma, Triatomines, Viruses, Whole genome amplification.
My research at DLS focuses on: 1) using single molecule genomics and NGS technologies to characterise pathogens of animals, humans and plants with the aim of developing novel diagnostics / methods of control / vaccines; 2) using meta-genomic and meta-transcriptomic approaches to study host - pathogen - microbiome interactions.
Current examples of my research include:
- Anopheles microbiome (with London School of Hygiene and Tropical Medicine).
- Development of multiplex PCR and amplicon sequencing techniques to characterise Anopheles and Plasmodium species, genotypes and drug resistance loci (with London School of Hygiene and Tropical Medicine).
- Drug resistance detection in Echinococcus vermicularis (with Hosptial for Tropical Diseases).
- The detection and characterisation of unknown human viruses (with Public Health England, Liverpool and Cambridge Universities).
- Meta-genomics to identify microbiota associated with chronic lung disease (MEDLUNG project led by Luis Mur in collaboration with the NHS and Swansea University).
- Campylobacter jejuni bacteriophage genomics (in collaboration with Jim Ajioka, Cambridge University and Illumina UK Ltd).
- Control of Campylobacter jejuni in chickens using novel antimicrobial agents (KESS and TSB funded with several commercial partners).
- Control of Eimeria species in chickens (collaboration with Damer Blake, Royal Veterinary College and Natural Feeds and Fertilizers Ltd).
- Isolation and genomic characterisation of Eimeria species causing coccidiosis in ruminants (Animal Plant Health Agency and Wales Veterinary Sciences Centre).
- Genomics of commensal gut bacteria isolated from blood sucking Rhodnius prolixus insects (Swansea University).
- Development of SMG and NGS approaches to characterise genomes of clinical and veterinary isolates of Cryptosporidium spp. (KESS funded, with Animal Plant Health Agency, Kevin Tyler - University of East Anglia, Martin Swain, UK Cryptosporidium Reference Lab, Wales Veterinary Sciences Centre).
- Genomics of pathogenic and probiotic Enterococcal spp. (Institute of Experimental Medicine, St. Petersberg, Russia).
- Slime mould mutant genomics (collaboration with Rob Kay and Gareth Bloomfield, MRC LMB).
Gwybodaeth ychwanegol
As a DLS Admissions Tutor I am responsible for entry into Biochemistry, Biology, Biology and Climate Change, Ecology, Genetics, Genetics and Biochemistry, Microbiology and Plant Sciences undergraduate schemes. Scheme leader for the MRes in Parasite Control postgraduate scheme. Module Coordinator for MSc Dissertation (BRM3560), Cell and Cancer Biology (BR25920) and Hot Topics in Parasite Control (BRM0920).
Elected to the British Society for Parasitology (BSP) Council (2015-); Honorary Treasurer (2018-2022), currently providing maternity cover for Dr Poppy Lamberton who took over as Honorary Treasurer in 2022. Member of the UK Standards for Microbiology Investigations Steering Committee (2015-). Previously an elected member of the Society of General Microbiology (now Microbiology Society) Eukaryotic Microbiology Committee (Infectious Disease theme, 2010-2014). Member of the Aberystwyth Learning and Teaching Conference committee. Member of the AberInnovation Academic Advisory Goup.
Organised the 2018 BSP Spring meeting at Aberystwyth University in collaboration with the British Association for Veterinary Parasitology and the British Ecological Society. I have organised several other meetings including the 2009 and 2010 Cambridge NGS Bioinformatics meetings and was one of the organisers of the 2021 on-line BSP Spring meeting.
Member of the BAVP, BSP, Microbiology Society, Royal Society of Tropical Medicine and Hygiene.
Safleoedd allanol
Member of Eukaryotic Division Committee, Microbiology Society
01 Medi 2012 → 30 Medi 2015
Arbenigedd sy’n gysylltiedig â NDC y CU
Yn 2015, cytunodd gwladwriaethau sy’n aelodau'r Cenhedloedd Unedig ar 17 o Nodau Datblygu Cynaliadwy (NDC) byd-eang i ddod â thlodi i ben, diogelu’r blaned a sicrhau ffyniant i bawb. Mae gwaith y person hwn yn cyfrannu at y NDC canlynol:
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NDC 3 Iechyd a Llesiant Da
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NDC 6 Dŵr Glân a Glanweithdra
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NDC 15 Bywyd ar y Tir
Ôl bys
- 1 Proffiliau Tebyg
Cydweithrediadau a’r prif feysydd ymchwil yn ystod y pum mlynedd ddiwethaf
Proffiliau
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Kathryn Diane Mackinnon
Unigolyn: Doethur mewn Athroniaeth
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Angel Rumney
Unigolyn: Doethur mewn Athroniaeth
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Abigail Louisa Webb
Unigolyn: Doethur mewn Athroniaeth
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Investigating within-host population diversity of Cryptosporidium parvum using BlooMine
Morris, A. V., Connor, T., Pachebat, J. & Swain, M., 20 Tach 2025, Yn: BMC Genomics. 26, 1, 14 t., 1067.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil1 Wedi eu Llwytho i Lawr (Pure) -
Microbiomes attached to fresh perennial ryegrass are temporally resilient and adapt to changing ecological niches
Huws, S. A., Edwards, J. E., Lin, W., Rubino, F., Alston, M., Swarbreck, D., Caim, S., Stevens, P. R., Pachebat, J., Won, M. Y., Oyama, L. B., Creevey, C. J. & Kingston-Smith, A. H., 01 Rhag 2021, Yn: Microbiome. 9, 1, 17 t., 143.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil31 Dyfyniadau (Scopus)232 Wedi eu Llwytho i Lawr (Pure) -
Generating Reliable Genome Assemblies of Intestinal Protozoans from Clinical Samples for the Purpose of Biomarker Discovery
Morris, A., Pachebat, J., Tyson, G., Robinson, G., Chalmers, R. & Swain, M., 2020, Biomedical Engineering Systems and Technologies - 12th International Joint Conference, BIOSTEC 2019, Revised Selected Papers. Roque, A., Gamboa, H., Tomczyk, A., De Maria, E., Putze, F., Moucek, R. & Fred, A. (gol.). Springer Nature, t. 216-241 26 t. (Communications in Computer and Information Science; Cyfrol 1211 CCIS).Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Trafodion Cynhadledd (ISBN)
2 Dyfyniadau (Scopus) -
The Isolation and Genome Sequencing of Five Novel Bacteriophages From the Rumen Active Against Butyrivibrio fibrisolvens
Friedersdorff, J. C. A., Kingston-Smith, A. H., Pachebat, J. A., Cookson, A. R., Rooke, D. & Creevey, C. J., 14 Gorff 2020, Yn: Frontiers in Microbiology. 11, 13 t., 1588.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil20 Dyfyniadau (Scopus)178 Wedi eu Llwytho i Lawr (Pure) -
Domestication of Campylobacter jejuni NCTC 11168
Pascoe, B., Williams, L. K., Calland, J. K., Meric, G., Hitchings, M. D., Dyer, M., Ryder, J., Shaw, S., Lopes, B. S., Chintoan-Uta, C., Allan, E., Vidal, A., Fearnley, C., Everest, P., Pachebat, J. A., Cogan, T. A., Stevens, M. P., Humphrey, T. J., Wilkinson, T. S. & Cody, A. J. & 12 eraill, , 16 Gorff 2019, Yn: Microbial genomics. 5, 7, 000279.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil34 Dyfyniadau (Scopus)208 Wedi eu Llwytho i Lawr (Pure) -
Evolutionary genomics of anthroponosis in Cryptosporidium
Nader, J., Mathers, T., Ward, B., Pachebat, J. A., Swain, M., Robinson, G., Chalmers, R. M., Hunter, P. R., van Oosterhout, C. & Tyler, K., 01 Mai 2019, Yn: Nature Microbiology. 4, 5, t. 826-836 11 t.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil109 Dyfyniadau (Scopus)379 Wedi eu Llwytho i Lawr (Pure) -
Genomic analysis of bacteria in the Acute Oak Decline pathobiome
Doonan, J., Denman, S., Pachebat, J. A. & McDonald, J., 08 Ion 2019, Yn: Microbial genomics. 5, 1, 000240.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil59 Dyfyniadau(SciVal)224 Wedi eu Llwytho i Lawr (Pure) -
Identifying and Resolving Genome Misassembly Issues Important for Biomarker Discovery in the Protozoan Parasite, Cryptosporidium
Morris, A., Pachebat, J., Robinson, G., Chalmers, R. M. & Swain, M., 2019, Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies : Volume 3: BIOINFORMATICS. De Maria, E., Fred, A. & Gamboa, H. (gol.). Prague: Science and Technology Publications, Cyfrol 3. t. 90-100 11 t. (BIOINFORMATICS 2019 - 10th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019).Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Trafodion Cynhadledd (ISBN)
Mynediad agored4 Dyfyniadau (Scopus) -
A pilot study using metagenomic sequencing of the sputum microbiome suggests potential bacterial biomarkers for lung cancer
Cameron, S., Lewis, K. E., Huws, S., Hegarty, M., Lewis, P. D., Pachebat, J. A. & Mur, L., 25 Mai 2017, Yn: PLoS ONE. 12, 5, 17 t., e0177062.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil165 Dyfyniadau (Scopus)313 Wedi eu Llwytho i Lawr (Pure) -
C 4 photosynthesis in the rice paddy: Insights from the Noxious Weed Echinochloa glabrescens
Covshoff, S., Szecowka, M., Hughes, T., Smith-Unna, R., Kelly, S., Bailey, K., Sage, T., Pachebat, J., Leegood, R. & Hibberd, J., 01 Ion 2016, Yn: Plant Physiology. 170, 1, t. 57-73 17 t.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil29 Dyfyniadau (Scopus)301 Wedi eu Llwytho i Lawr (Pure) -
Draft Genome Sequence of Probiotic Enterococcus faecium Strain L-3
Karaseva, A., Tsapieva, A., Pachebat, J. A. & Suvorov, A., 28 Ion 2016, Yn: Genome Announcements. 4, 1, e01599-15.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil11 Dyfyniadau (Scopus)214 Wedi eu Llwytho i Lawr (Pure)
Setiau Data Ymchwil
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Evolutionary genomics of anthroponosis in Cryptosporidium
Swain, M., Pachebat, J. A., Robinson, G. & Chalmers, R. M., Prifysgol Aberystwyth | Aberystwyth University, 26 Medi 2018
Dangosydd eitem ddigidol (DOI): 10.20391/8f137d06-4827-4829-ae7b-fac592d57942
Set ddata
Ffeil -
Plant-attached microbiomes temporally transition into specialised ecological niches
Huws, S., Edwards, J. E., Lin, W., Rubino, F., Alston, M., Swarbreck, D., Caim, S., Rees Stevens, P., Pachebat, J., Won, M.-Y., Oyama, L. B., Creevey, C. & Kingston-Smith, A., Prifysgol Aberystwyth | Aberystwyth University, 03 Ebr 2020
Dangosydd eitem ddigidol (DOI): 10.17605/OSF.IO/RX9H2
Set ddata
Prosiectau
- 6 Wedi Gorffen
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Development of a Dictyostelium discoideum based rapid drug screening system
Pachebat, J. (Arweinydd y Prosiect)
SSN Educational and Charitable Trust
01 Gorff 2019 → 30 Meh 2020
Prosiect: Ymchwil a ariannwyd yn allanol
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Understanding the impact of cryptosporidiosis in livestock farms in England and Wales
Pachebat, J. (Arweinydd y Prosiect)
19 Mai 2014 → 19 Tach 2014
Prosiect: Ymchwil a ariannwyd yn allanol
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Characterisation and exploitation of bacterial endophytes in C4 energy crops
Farrar, K. (Arweinydd y Prosiect), Pachebat, J. (Cyd‑arweinydd Ymchwil), Donnison, I. (Cyd‑arweinydd Ymchwil), Huang, L. (Cyd‑arweinydd Ymchwil) & Adams, J. (Cyd‑arweinydd Ymchwil)
Biotechnology and Biological Sciences Research Council
01 Tach 2012 → 31 Hyd 2016
Prosiect: Ymchwil a ariannwyd yn allanol
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RSB : Rumen Systems Biology
Kingston-Smith, A. (Arweinydd y Prosiect), Swain, M. (Cyd‑arweinydd Ymchwil), Mur, L. (Cyd‑arweinydd Ymchwil), Creevey, C. (Cyd‑arweinydd Ymchwil), Allison, G. (Cyd‑arweinydd Ymchwil), Scollan, N. (Cyd‑arweinydd Ymchwil), Pachebat, J. (Cyd‑arweinydd Ymchwil), Newbold, J. (Cyd‑arweinydd Ymchwil), Morphew, R. (Cyd‑arweinydd Ymchwil), Griffith, G. (Cyd‑arweinydd Ymchwil) & Huws, S. (Cyd‑arweinydd Ymchwil)
Biotechnology and Biological Sciences Research Council
01 Ebr 2012 → 31 Maw 2017
Prosiect: Ymchwil a ariannwyd yn allanol
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Virus discovery in cases of undiagnosed gastroenteritis
Pachebat, J. (Arweinydd y Prosiect)
01 Chwef 2011 → 30 Rhag 2012
Prosiect: Ymchwil a ariannwyd yn allanol
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Developing RAD markers as a resource for plant breeding
Hegarty, M. (Arweinydd y Prosiect), Pachebat, J. (Cyd‑arweinydd Ymchwil), Powell, W. (Cyd‑arweinydd Ymchwil) & Thorogood, D. (Cyd‑arweinydd Ymchwil)
Biotechnology and Biological Sciences Research Council
01 Medi 2010 → 29 Chwef 2012
Prosiect: Ymchwil a ariannwyd yn allanol
Gweithgareddau
- 1 Cynhadledd
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British Society for Parasitology Spring Conference
Pachebat, J. A. (Trefnydd)
08 Ebr 2018 → 11 Ebr 2018Gweithgaredd: Cymryd rhan mewn digwyddiad neu drefnu digwyddiad › Cynhadledd
Gwobrau
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Council Member of the British Society for Parasitology
Pachebat, J. (Derbynydd), 12 Ebr 2016
Gwobr: Etholiad i gymdeithas ddysgedig
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Eukaryotic Microbiology Committee of the Society for General Microbiology
Pachebat, J. (Derbynydd), 2013
Gwobr: Etholiad i gymdeithas ddysgedig
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Honorary Treasurer of the British Society for Parasitology
Pachebat, J. (Derbynydd), 15 Ebr 2019
Gwobr: Penodiad
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UK Standards for Microbiology Investigations Steering Committee
Pachebat, J. (Derbynydd), 2016
Gwobr: Penodiad