Developing a 'Validation Portfolio' to Exploit Key Virulence Proteins in Fasciola Species for Parasite Control

Canlyniadau chwilio

• 2022

  In silico characterisation of the complete Ly6 protein family in Fasciola gigantica supported through transcriptomics of the newly-excysted juveniles

  Davey, S. D., Chalmers, I. W., Fernandez-Fuentes, N., Swain, M. T., Smith, D., Abbas Abidi, S. M., Saifullah, M. K., Raman, M., Ravikumar, G., McVeigh, P., Maule, A. G., Brophy, P. M. & Morphew, R. M., 17 Ion 2022, Yn: Molecular Omics. 18, 1, t. 45-56 12 t.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  Mynediad agored

  Ffeil

  • Vaccine Efficacy 100%
  • Protein Family 75%
  • Fasciola Gigantica 50%
  • Trematoda 50%
  • Transcriptomics 50%

  8 Dyfyniadau (Scopus)

  95 Wedi eu Llwytho i Lawr (Pure)

• 2019

  X-ray structure of Fasciola hepatica Sigma class glutathione transferase 1 reveals a disulfide bond to support stability in gastro-intestinal environment

  Line, K., Isupov, M. N., LaCourse, E. J., Cutress, D., Morphew, R., Brophy, P. & Littlechild, J. A., 01 Rhag 2019, Yn: Scientific Reports. 9, 1, 902.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  Mynediad agored

  Ffeil

  • Fasciola Hepatica 100%
  • Disulfide Bond 100%
  • Glutathione 100%
  • Host 100%
  • Parasite 66%

  8 Dyfyniadau (Scopus)

  197 Wedi eu Llwytho i Lawr (Pure)

• 2016

  Calmodulin disruption impacts growth and motility in juvenile liver fluke

  McCammick, E., McVeigh, P., McCusker, P., Timson, D., Morphew, R., Brophy, P., Marks, N., Mousley, A. & Maule, A., 27 Ion 2016, Yn: Parasites & Vectors. 9, N/A, 13 t., 46.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  Mynediad agored

  Ffeil

  • RNA Interference 100%
  • Growth 87%
  • Fluke 87%
  • Trematode 87%
  • Calmodulin 75%

  22 Dyfyniadau (Scopus)

  190 Wedi eu Llwytho i Lawr (Pure)

• Exploring and Expanding the Fatty-Acid-Binding Protein Superfamily in Fasciola Species

  Morphew, R., Wilkinson, T., MacKintosh, N., Jahndel, V., Paterson, S., McVeigh, P., Abbas Abidi, S. M., Saifullah, K., Raman, M., Ravikumar , G., LaCourse, E. J., Maule, A. G. & Brophy, P., 02 Medi 2016, Yn: Journal of Proteome Research. 15, 9, t. 3308-3321 14 t.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  Mynediad agored

  Ffeil

  • Protein Z 100%
  • Liver Fluke 80%
  • Vaccine 80%
  • Protein Superfamily 80%
  • Cladistics 80%

  26 Dyfyniadau (Scopus)

  303 Wedi eu Llwytho i Lawr (Pure)

• 2014

  RNAi dynamics in juvenile Fasciola spp. liver flukes reveals the persistence of gene silencing in vitro

  McVeigh, P., McCammick, E., McCusker, P., Morphew, R. M., Mousley, A., Abidi, A., Saifullah, K. M., Muthusamy, R., Gopalakrishnan, R., Spithill, T. W., Dalton, J. P., Brophy, P. M., Marks, N. J. & Maule, A. G., 25 Medi 2014, Yn: PLoS Neglected Tropical Diseases. 8, 9, 13 t., e3185.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  Mynediad agored

  Ffeil

  • RNA Interference 100%
  • Fasciola Hepatica 66%
  • Dynamics 44%
  • Small Interfering RNA 33%
  • Gene Silencing 22%

  49 Dyfyniadau (Scopus)

  160 Wedi eu Llwytho i Lawr (Pure)

• Time-dependent tegumental surface changes in juvenile Fasciola gigantica in response to triclabendazole treatment in goat

  Ahammed Shareef, P. A., Brennan, G. P., McVeigh, P., Hannan Khan, M. A., Morphew, R. M., Mousley, A., Marks, N. J., Khalid Saifullah, M. K., Brophy, P. M., Maule, A. G. & Abidi, S. M. A., Awst 2014, Yn: Acta Tropica. 136, t. 108-117 10 t.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  Mynediad agored

  Ffeil

  • Triclabendazole 100%
  • Fluke 100%
  • Goat 75%
  • Lesion 50%
  • Liver Fluke 50%

  16 Dyfyniadau (Scopus)

  83 Wedi eu Llwytho i Lawr (Pure)

• 2013

  Early hepatic and peritoneal changes and immune response in goats vaccinated with a recombinant glutathione transferase sigma class and challenged with Fasciola hepatica.

  Zafra, R., Pérez-Écija, R. A., Buffoni, L., Pacheco, I. L., Martínez-Moreno, A., Lacourse , E. J., Perally, S., Brophy, P. M. & Pérez, J., 01 Meh 2013, Yn: Research in Veterinary Science. 94, 3, t. 602-609 8 t.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  • Goat 100%
  • Infection 66%
  • Immune Response 50%
  • T Cell Subset 33%
  • Eosinophil 33%

  30 Dyfyniadau (Scopus)

• Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica released by Nonidet P40

  Morphew, R. M., Hamilton, C. M., Wright, H. A., Dowling, D. J., O'Neill, S. M. & Brophy, P. M., 31 Ion 2013, Yn: Veterinary Parasitology. 191, 3-4, t. 379–385 7 t.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  Mynediad agored

  Ffeil

  • Fasciola Hepatica 100%
  • Extract 100%
  • NP-40 66%
  • Two-Dimensional Gel Electrophoresis 33%
  • Stress 33%

  25 Dyfyniadau (Scopus)

  106 Wedi eu Llwytho i Lawr (Pure)

• 2012

  Anthelmintic metabolism in parasitic helminths: proteomic insights

  Brophy, P. M., Mackintosh, N. & Morphew, R. M., Awst 2012, Yn: Parasitology. 139, 9, t. 1205-1217 13 t.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  • Metabolism 100%
  • Introspection 66%
  • Protein Processing 33%
  • Membrane 33%
  • Equus 33%

  26 Dyfyniadau (Scopus)

• The Sigma Class glutathione transferase from the liver fluke Fasciola hepatica

  LaCourse, E. J., Perally, S., Morphew, R. M., Moxon, J. V., Prescott, M. C., Dowling, D. J., O'Neill, S. M., Kipar, A., Hetzel, U., Hoey, E., Zafra, R., Buffoni, L., Arévalo, J. P. & Brophy, P. M., 01 Mai 2012, Yn: PLoS Neglected Tropical Diseases. 6, 5, e1666.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  Mynediad agored

  Ffeil

  • Fasciola Hepatica 100%
  • Vaccine 85%
  • Liver Fluke 71%
  • Western Blot 42%
  • Adult 28%

  68 Dyfyniadau (Scopus)

  268 Wedi eu Llwytho i Lawr (Pure)

• 2011

  Towards delineating functions within the fasciola secreted cathepsin L protease family by integrating in vivo based sub-proteomics and phylogenetics

  Morphew, R. M., Wright, H. A., LaCourse, E. J., Porter, J., Barrett, J., Woods, D. J. & Brophy, P. M., 04 Ion 2011, Yn: PLoS Neglected Tropical Diseases. 5, 1, e-937.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  Mynediad agored

  Ffeil

  • Cathepsin L 100%
  • Protease 77%
  • Host 44%
  • Phylogeny 33%
  • Cladistics 33%

  39 Dyfyniadau (Scopus)

  203 Wedi eu Llwytho i Lawr (Pure)

• 2010

  Immune responses directed at egg proteins during experimental infection with the liver fluke Fasciola hepatica

  Moxon, J. V., Flynn, R., Golden, O., Hamilton, J. V., Mulcahy, G. & Brophy, P. M., 01 Chwef 2010, Yn: Parasite Immunology. 32, 2, t. 111-124 14 t.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  Mynediad agored

  Ffeil

  • Immune Response 100%
  • Egg Protein 100%
  • Fasciola Hepatica 100%
  • Liver Fluke 100%
  • Experimental Infection 100%

  16 Dyfyniadau (Scopus)

  45 Wedi eu Llwytho i Lawr (Pure)

• Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses

  Dowling, D. J., Hamilton, C. M., Donnelly, S., La Course, J., Brophy, P. M., Dalton, J. & O'Neill, S. M., Chwef 2010, Yn: Infection and Immunity. 78, 2, t. 793-801 9 t.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  • Dendritic Cell 100%
  • Immune Response 66%
  • Host 50%
  • Molecule 50%
  • Antigen 33%

  121 Dyfyniadau (Scopus)

• Proteomic analysis of embryonic Fasciola hepatica: Characterization and antigenic potential of a developmentally regulated heat shock protein

  Moxon, J. V., LaCourse, E. J., Wright, H. A., Perally, S., Prescott, M. C., Gillard, J. L., Barrett, J., Hamilton, J. V. & Brophy, P. M., 19 Ebr 2010, Yn: Veterinary Parasitology. 169, 1-2, t. 62-75 14 t.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  Ffeil

  • Proteins 100%
  • Hepatica 88%
  • Eggs 77%
  • Fasciola Hepatica 55%
  • Clones 33%

  35 Dyfyniadau (Scopus)

  95 Wedi eu Llwytho i Lawr (Pure)