Flatworm DNA methylation: deciphering the mark and characterising the machinery

Hoffmann, Karl (Prif Ymchwilydd)

Adran y Gwyddorau Bywyd

Prosiect: Ymchwil a ariannwyd yn allanol

Statws	Wedi gorffen
Dyddiad cychwyn/gorffen dod i rym	15 Ebr 2013 → 14 Ebr 2016

Cyllid

Biotechnology and Biological Sciences Research Council (Funder reference unknown): £457,828.00

Nodau Datblygu Cynaliadwy y CU

Yn 2015, cytunodd gwladwriaethau sy’n aelodau'r Cenhedloedd Unedig ar 17 o Nodau Datblygu Cynaliadwy (NDC) byd-eang i ddod â thlodi i ben, diogelu’r blaned a sicrhau ffyniant i bawb. Mae’r prosiect hwn yn cyfrannu at y NDC canlynol:

7 Erthygl
1 Erthygl Adolygu

The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets
Whatley, K., Padalino, G., Whiteland, H., Geyer, K. K., Hulme, B. J., Chalmers, I., Forde-Thomas, J., Ferla, S., Brancale, A. & Hoffmann, K., 15 Tach 2019, Yn: PLoS Neglected Tropical Diseases. 13, 11, 24 t., e0007693.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored
Ffeil
21 Dyfyniadau (Scopus)

232 Wedi eu Llwytho i Lawr (Pure)
Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni
Geyer, K., Munshi, S. E., Whiteland, H., Fernandez-Fuentes, N., Phillips, D. & Hoffmann, K., 28 Meh 2018, Yn: PLoS Pathogens. 14, 6, e1007107.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored
Ffeil
12 Dyfyniadau (Scopus)

210 Wedi eu Llwytho i Lawr (Pure)
The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities
Geyer, K., Munshi, S. E., Vickers, M., Squance, M., Wilkinson, T., Berrar, D., Chaparro, C., Swain, M. & Hoffmann, K., 01 Awst 2018, Yn: International Journal for Parasitology: Drugs and Drug Resistance. 8, 2, t. 213-222 10 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored
Ffeil
19 Dyfyniadau (Scopus)

207 Wedi eu Llwytho i Lawr (Pure)
(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach
Cosseau, C., Wolkenhauer, O., Padalino, G., Geyer, K., Hoffmann, K. & Grunau, C., 01 Ebr 2017, Yn: Trends in Parasitology. 33, 4, t. 285-294 10 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl Adolygu › adolygiad gan gymheiriaid

Mynediad agored
Ffeil
27 Dyfyniadau (Scopus)

215 Wedi eu Llwytho i Lawr (Pure)
The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni
Geyer, K., Niazi, U., Duval, D., Cosseau, C., Tomlinson, C., Chalmers, I., Swain, M., Cutress, D., Bickham-Wright, U., Munshi, S. E., Grunau, C., Yoshino, T. P. & Hoffmann, K., 16 Mai 2017, Yn: PLoS Neglected Tropical Diseases. 11, 5, 29 t., e0005246.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored
Ffeil
35 Dyfyniadau (Scopus)

212 Wedi eu Llwytho i Lawr (Pure)
Whole genome analysis of a schistosomiasis-transmitting freshwater snail
Adema, C. M., Hillier, L. W., Jones, C. S., Loker, E. S., Knight, M., Minx, P., Oliveira, G., Raghavan, N., Shedlock, A., do Amaral, L. R., Arican-Goktas, H. D., Assis, J. G., Baba, E. H., Baron, O. L., Bayne, C. J., Bickham-Wright, U., Biggar, K. K., Blouin, M., Bonning, B. C. & Botka, C. & 97 eraill, Bridger, J. M., Buckley, K. M., Buddenborg, S. K., Lima Caldeira, R., Carleton, J., Carvalho, O. S., Castillo, M. G., Chalmers, I. W., Christensens, M., Clifton, S., Cosseau, C., Coustau, C., Cripps, R. M., Cuesta-Astroz, Y., Cummins, S. F., Di Stephano, L., Dinguirard, N., Duval, D., Emrich, S., Feschotte, C., Feyereisen, R., Fitzgerald, P., Fronick, C., Fulton, L., Galinier, R., Gava, S. G., Geusz, M., Geyer, K. K., Giraldo-Calderón, G. I., de Souza Gomes, M., Gordy, M. A., Gourbal, B., Grunau, C., Hanington, P. C., Hoffmann, K. F., Hughes, D., Humphries, J., Jackson, D. J., Jannotti-Passos, L. K., De Jesus Jeremias, W., Jobling, S., Kamel, B., Kapusta, A., Kaur, S., Koene, J. M., Kohn, A. B., Lawson, D., Lawton, S. P., Liang, D., Limpanont, Y., Liu, S., Lockyer, A. E., Lovato, T. L., Ludolf, F., Magrini, V., Mcmanus, D. P., Medina, M., Misra, M., Mitta, G., Mkoji, G. M., Montague, M. J., Montelongo, C., Moroz, L. L., Munoz-Torres, M. C., Niazi, U., Noble, L. R., Oliveira, F. S., Pais, F. S., Papenfuss, A. T., Peace, R., Pena, J. J., Pila, E. A., Quelais, T., Raney, B. J., Rast, J. P., Rollinson, D., Rosse, I. C., Rotgans, B., Routledge, E. J., Ryan, K. M., Scholte, L. L. S., Storey, K. B., Swain, M., Tennessen, J. A., Tomlinson, C., Trujillo, D. L., Volpi, E. V., Walker, A. J., Wang, T., Wannaporn, I., Warren, W. C., Wu, X.-J., Yoshino, T. P., Yusuf, M., Zhang, S.-M., Zhao, M. & Wilson, R. K., 16 Mai 2017, Yn: Nature Communications. 8, t. 15451 15451.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored
Ffeil
198 Dyfyniadau (Scopus)

171 Wedi eu Llwytho i Lawr (Pure)
DISMISS: Detection of stranded methylation in MeDIP-Seq data
Niazi, U., Geyer, K. K., Vickers, M. J., Hoffmann, K. & Swain, M., 29 Gorff 2016, Yn: BMC Bioinformatics. 17, 1, 295.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored
Ffeil
9 Dyfyniadau (Scopus)

157 Wedi eu Llwytho i Lawr (Pure)
Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes
Geyer, K. K., Chalmers, I. W., MacKintosh, N. D., Hirst, J. E., Geoghegan, R., Badets, M., Brophy, P. M., Brehm, K. & Hoffmann, K. F., 09 Gorff 2013, Yn: BMC Genomics. 14, 1, 462.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Mynediad agored
Ffeil
33 Dyfyniadau (Scopus)

195 Wedi eu Llwytho i Lawr (Pure)

4 Cynhadledd
2 Gwesteio ymwelydd academaidd
2 Cyflwyniad llafar
2 Ymweld â sefydliad academaidd allanol
Mwy
- 1 Gweithdy, Seminar, neu Cwrs

Scientific seminar delivered to staff and students at Leiden University Medical Center, the Netherlands,
Hoffmann, K. (Cyfranogwr)
2017
Gweithgaredd: Cymryd rhan mewn digwyddiad neu drefnu digwyddiad › Gweithdy, Seminar, neu Cwrs
Life Sciences Research Network Wales
Hoffmann, K. (Cyfranogwr)
30 Tach 2016 → 01 Rhag 2016
Gweithgaredd: Cymryd rhan mewn digwyddiad neu drefnu digwyddiad › Cynhadledd
Keystone Symposia
Hoffmann, K. (Cyfranogwr)
24 Ion 2016 → 26 Ion 2016
Gweithgaredd: Cymryd rhan mewn digwyddiad neu drefnu digwyddiad › Cynhadledd
Liverpool School of Tropical Medicine
Hoffmann, K. (Ymchwilydd Gwadd)
2016
Gweithgaredd: Ymweld â sefydliad allanol › Ymweld â sefydliad academaidd allanol
The University of Manchester
Hoffmann, K. (Ymchwilydd Gwadd)
2016
Gweithgaredd: Ymweld â sefydliad allanol › Ymweld â sefydliad academaidd allanol
International Flatworm Biology Symposium
Geyer, K. K. (Cyfranogwr), Whatley, K. (Cyfranogwr) & Hoffmann, K. (Cyfranogwr)
03 Awst 2015
Gweithgaredd: Cymryd rhan mewn digwyddiad neu drefnu digwyddiad › Cynhadledd
Cardiff University
Hoffmann, K. (Gwesteiwr)
Ion 2015 → Ebr 2015
Gweithgaredd: Gwesteio ymwelydd › Gwesteio ymwelydd academaidd
Penglais School Visit and lecture on Genomics as part of the Genetics Roadshow
Hoffmann, K. (Siaradwr)
10 Ebr 2013
Gweithgaredd: Sgwrs neu gyflwyniad › Cyflwyniad llafar
British Society for Parasitology Spring Meeting 2013
Nowacki, F. (Cyfranogwr), Edwards, J. (Cyfranogwr), Geyer, K. K. (Cyfranogwr), Whatley, K. (Cyfranogwr) & Hoffmann, K. (Cyfranogwr)
09 Ebr 2013 → Ebr 2015
Gweithgaredd: Cymryd rhan mewn digwyddiad neu drefnu digwyddiad › Cynhadledd
Edinburgh University
Nowacki, F. (Gwesteiwr)
2013
Gweithgaredd: Gwesteio ymwelydd › Gwesteio ymwelydd academaidd
Flatworm DNA methylation: deciphering the mark and characterising the machinery.
Hoffmann, K. (Siaradwr)
2013 → 2015
Gweithgaredd: Sgwrs neu gyflwyniad › Cyflwyniad llafar

Flatworm DNA methylation: deciphering the mark and characterising the machinery

Manylion y Prosiect

Cyllid

Nodau Datblygu Cynaliadwy y CU

Ôl bys

The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni

The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities

(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach

The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni

Whole genome analysis of a schistosomiasis-transmitting freshwater snail

DISMISS: Detection of stranded methylation in MeDIP-Seq data

Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes

Scientific seminar delivered to staff and students at Leiden University Medical Center, the Netherlands,

Life Sciences Research Network Wales

Keystone Symposia

Liverpool School of Tropical Medicine

The University of Manchester

International Flatworm Biology Symposium

Cardiff University

Penglais School Visit and lecture on Genomics as part of the Genetics Roadshow

British Society for Parasitology Spring Meeting 2013

Edinburgh University

Flatworm DNA methylation: deciphering the mark and characterising the machinery.

Flatworm DNA methylation: deciphering the mark and characterising the machinery

Manylion y Prosiect

Cyllid

Nodau Datblygu Cynaliadwy y CU

Ôl bys

Allbwn ymchwil

Gweithgareddau