Flatworm DNA methylation: deciphering the mark and characterising the machinery

Canlyniadau chwilio

• 2019

  The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

  Whatley, K., Padalino, G., Whiteland, H., Geyer, K. K., Hulme, B. J., Chalmers, I., Forde-Thomas, J., Ferla, S., Brancale, A. & Hoffmann, K., 15 Tach 2019, Yn: PLoS Neglected Tropical Diseases. 13, 11, 24 t., e0007693.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  Mynediad agored

  Ffeil

  • Probe 100%
  • Epigenetics 75%
  • Epigenomics 75%
  • Schistosoma 62%
  • Glycogen Synthase Kinase 50%

  25 Dyfyniadau (Scopus)

  296 Wedi eu Llwytho i Lawr (Pure)

• 2018

  Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni

  Geyer, K., Munshi, S. E., Whiteland, H., Fernandez-Fuentes, N., Phillips, D. & Hoffmann, K., 28 Meh 2018, Yn: PLoS Pathogens. 14, 6, e1007107.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  Mynediad agored

  Ffeil

  • Epigenomics 100%
  • Schistosoma 100%
  • Stem Cell 66%
  • Schistosoma Mansoni 66%
  • Schistosomiasis 66%

  12 Dyfyniadau (Scopus)

  271 Wedi eu Llwytho i Lawr (Pure)

• The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities

  Geyer, K., Munshi, S. E., Vickers, M., Squance, M., Wilkinson, T., Berrar, D., Chaparro, C., Swain, M. & Hoffmann, K., 01 Awst 2018, Yn: International Journal for Parasitology: Drugs and Drug Resistance. 8, 2, t. 213-222 12 t.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  Mynediad agored

  Ffeil

  • Azacitidine 100%
  • Female 46%
  • Schistosoma 46%
  • Scanning Electron Microscopy 30%
  • Fertility 23%

  21 Dyfyniadau (Scopus)

  202 Wedi eu Llwytho i Lawr (Pure)

• 2017

  (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach

  Cosseau, C., Wolkenhauer, O., Padalino, G., Geyer, K., Hoffmann, K. & Grunau, C., 01 Ebr 2017, Yn: Trends in Parasitology. 33, 4, t. 285-294 10 t.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl Adolygu › adolygiad gan gymheiriaid

  Mynediad agored

  Ffeil

  • Schistosoma Mansoni 100%
  • Phenotype 100%
  • Inheritance 100%
  • Gene-Environment Interaction 50%
  • Schistosoma 50%

  30 Dyfyniadau (Scopus)

  269 Wedi eu Llwytho i Lawr (Pure)

• The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni

  Geyer, K., Niazi, U., Duval, D., Cosseau, C., Tomlinson, C., Chalmers, I., Swain, M., Cutress, D., Bickham-Wright, U., Munshi, S. E., Grunau, C., Yoshino, T. P. & Hoffmann, K., 16 Mai 2017, Yn: PLoS Neglected Tropical Diseases. 11, 5, 29 t., e0005246.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  Mynediad agored

  Ffeil

  • Snail 100%
  • DNA Methylation 71%
  • Schistosoma 71%
  • 5 Methylcytosine 57%
  • 5-Methylcytosine 57%

  40 Dyfyniadau (Scopus)

  232 Wedi eu Llwytho i Lawr (Pure)

• Whole genome analysis of a schistosomiasis-transmitting freshwater snail

  Adema, C. M., Hillier, L. W., Jones, C. S., Loker, E. S., Knight, M., Minx, P., Oliveira, G., Raghavan, N., Shedlock, A., do Amaral, L. R., Arican-Goktas, H. D., Assis, J. G., Baba, E. H., Baron, O. L., Bayne, C. J., Bickham-Wright, U., Biggar, K. K., Blouin, M., Bonning, B. C. & Botka, C. & 97 eraill, Bridger, J. M., Buckley, K. M., Buddenborg, S. K., Lima Caldeira, R., Carleton, J., Carvalho, O. S., Castillo, M. G., Chalmers, I. W., Christensens, M., Clifton, S., Cosseau, C., Coustau, C., Cripps, R. M., Cuesta-Astroz, Y., Cummins, S. F., Di Stephano, L., Dinguirard, N., Duval, D., Emrich, S., Feschotte, C., Feyereisen, R., Fitzgerald, P., Fronick, C., Fulton, L., Galinier, R., Gava, S. G., Geusz, M., Geyer, K. K., Giraldo-Calderón, G. I., de Souza Gomes, M., Gordy, M. A., Gourbal, B., Grunau, C., Hanington, P. C., Hoffmann, K. F., Hughes, D., Humphries, J., Jackson, D. J., Jannotti-Passos, L. K., De Jesus Jeremias, W., Jobling, S., Kamel, B., Kapusta, A., Kaur, S., Koene, J. M., Kohn, A. B., Lawson, D., Lawton, S. P., Liang, D., Limpanont, Y., Liu, S., Lockyer, A. E., Lovato, T. L., Ludolf, F., Magrini, V., Mcmanus, D. P., Medina, M., Misra, M., Mitta, G., Mkoji, G. M., Montague, M. J., Montelongo, C., Moroz, L. L., Munoz-Torres, M. C., Niazi, U., Noble, L. R., Oliveira, F. S., Pais, F. S., Papenfuss, A. T., Peace, R., Pena, J. J., Pila, E. A., Quelais, T., Raney, B. J., Rast, J. P., Rollinson, D., Rosse, I. C., Rotgans, B., Routledge, E. J., Ryan, K. M., Scholte, L. L. S., Storey, K. B., Swain, M., Tennessen, J. A., Tomlinson, C., Trujillo, D. L., Volpi, E. V., Walker, A. J., Wang, T., Wannaporn, I., Warren, W. C., Wu, X.-J., Yoshino, T. P., Yusuf, M., Zhang, S.-M., Zhao, M. & Wilson, R. K., 16 Mai 2017, Yn: Nature Communications. 8, t. 15451 15451.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  Mynediad agored

  Ffeil

  • Snail 100%
  • Schistosomiasis 50%
  • Schistosoma Mansoni 16%
  • Immune Response 16%
  • Biomphalaria 16%

  221 Dyfyniadau (Scopus)

  192 Wedi eu Llwytho i Lawr (Pure)

• 2016

  DISMISS: Detection of stranded methylation in MeDIP-Seq data

  Niazi, U., Geyer, K. K., Vickers, M. J., Hoffmann, K. & Swain, M., 29 Gorff 2016, Yn: BMC Bioinformatics. 17, 1, 295.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  Mynediad agored

  Ffeil

  • Methylated DNA Immunoprecipitation 100%
  • DNA Strand 15%
  • Bisulfite Sequencing 7%
  • Apis mellifera 7%

  9 Dyfyniadau (Scopus)

  172 Wedi eu Llwytho i Lawr (Pure)

• 2013

  Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes

  Geyer, K. K., Chalmers, I. W., MacKintosh, N. D., Hirst, J. E., Geoghegan, R., Badets, M., Brophy, P. M., Brehm, K. & Hoffmann, K. F., 09 Gorff 2013, Yn: BMC Genomics. 14, 1, 462.

  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  Mynediad agored

  Ffeil

  • Platyhelminth 100%
  • Phylum 62%
  • Cytosine 50%
  • Methylation 50%
  • DNA Methylation 50%

  35 Dyfyniadau (Scopus)

  250 Wedi eu Llwytho i Lawr (Pure)