Allbwn Ymchwil fesul blwyddyn
Allbwn Ymchwil fesul blwyddyn
Manylion y Prosiect
Disgrifiad
FUGI proposes three primary aims:
‘Poly-omics’ characterisation of stem cell systems in S. mansoni (neoblast-like somatic cells, S1 vitellocytes and oogonia) and E. multilocularis (germinative cells).
Development of S. mansoni and E. multilocularis reverse genetic toolkits.
Establishment of E. multilocularis and S. mansoni immortal cell lines.
‘Poly-omics’ characterisation of stem cell systems in S. mansoni (neoblast-like somatic cells, S1 vitellocytes and oogonia) and E. multilocularis (germinative cells).
Development of S. mansoni and E. multilocularis reverse genetic toolkits.
Establishment of E. multilocularis and S. mansoni immortal cell lines.
| Statws | Wedi gorffen |
|---|---|
| Dyddiad cychwyn/gorffen dod i rym | 01 Hyd 2015 → 31 Maw 2022 |
Cyllid
- The Wellcome Trust (Funder reference unknown): £686,807.28
Nodau Datblygu Cynaliadwy y CU
Yn 2015, cytunodd gwladwriaethau sy’n aelodau'r Cenhedloedd Unedig ar 17 o Nodau Datblygu Cynaliadwy (NDC) byd-eang i ddod â thlodi i ben, diogelu’r blaned a sicrhau ffyniant i bawb. Mae’r prosiect hwn yn cyfrannu at y NDC canlynol:
Ôl bys
Archwilio’r pynciau ymchwil mae a wnelo'r prosiect hwn â nhw. Mae’r labelau hyn yn cael eu cynhyrchu’n seiliedig ar y dyfarniadau/grantiau sylfaenol. Gyda’i gilydd maen nhw’n ffurfio ôl bys unigryw.
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Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes
Padalino, G., Celatka, C., Rienhoff Jr., H. Y., Kalin, J. H., Cole, P. A., Lassalle, D., Forde-Thomas, J., Chalmers, I., Brancale, A., Grunau, C. & Hoffmann, K., 30 Maw 2023, Yn: Wellcome Open Research. 8, 146, 29 t., 146.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil1 Dyfyniad (Scopus)69 Wedi eu Llwytho i Lawr (Pure) -
Pulmonary inflammation promoted by type-2 dendritic cells is a feature of human and murine schistosomiasis
Houlder, E. L., Costain, A. H., Nambuya, I., Brown, S. L., Koopman, J. P. R., Langenberg, M. C. C., Janse, J. J., Hoogerwerf, M. A., Ridley, A. J. L., Forde-Thomas, J. E., Colombo, S. A. P., Winkel, B. M. F., Galdon, A. A., Hoffmann, K. F., Cook, P. C., Roestenberg, M., Mpairwe, H. & MacDonald, A. S., 01 Rhag 2023, Yn: Nature Communications. 14, 1, 12 t., 1863.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil4 Dyfyniadau (Scopus)154 Wedi eu Llwytho i Lawr (Pure) -
Using ChEMBL to Complement Schistosome Drug Discovery
Padalino, G., Coghlan, A., Pagliuca, G., Forde-Thomas, J., Berriman, M. & Hoffmann, K., 28 Ebr 2023, Yn: Pharmaceutics. 15, 5, 26 t., 1359.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil2 Dyfyniadau (Scopus)41 Wedi eu Llwytho i Lawr (Pure) -
Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation
Padalino, G., El-Sakkary, N., Liu, L. J., Liu, C., Harte, D. S. G., Barnes, R. E., Sayers, E., Forde-Thomas, J., Whiteland, H., Bassetto, M., Ferla, S., Johnson, G., Jones, A. T., Caffrey, C. R., Chalmers, I., Brancale, A. & Hoffmann, K. F., 15 Rhag 2021, Yn: European Journal of Medicinal Chemistry. 226, 19 t., 113823.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil7 Dyfyniadau (Scopus)147 Wedi eu Llwytho i Lawr (Pure) -
Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni
Craven, H., Bonsignore, R., Lenis, V., Santi, N., Berrar, D., Swain, M., Whiteland, H., Casini, A. & Hoffmann, K., 18 Chwef 2021, Yn: PLoS Neglected Tropical Diseases. 15, 2, 24 t., e0008770.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil6 Dyfyniadau (Scopus)146 Wedi eu Llwytho i Lawr (Pure) -
Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities
Padalino, G., Chalmers, I. W., Brancale, A. & Hoffmann, K. F., 13 Tach 2020, Yn: Wellcome Open Research. 5, 37 t., 169.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil6 Dyfyniadau (Scopus)75 Wedi eu Llwytho i Lawr (Pure) -
Mynediad agoredFfeil3 Wedi eu Llwytho i Lawr (Pure)
Setiau Data Ymchwil
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Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities - Extended data
Padalino, G., Chalmers, I. W., Brancale, A. & Hoffmann, K., figshare, 23 Meh 2020
Dangosydd eitem ddigidol (DOI): 10.6084/m9.figshare.12546449, https://figshare.com/articles/Identification_of_6-_piperazin-1-yl_-1_3_5-triazine_as_a_chemical_scaffold_with_broad_anti-schistosomal_activities/12546449/2
Set ddata
Ffeil -
Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary Figures
Padalino, G., Celatka, C. A., Young Rienhoff Jr, H., Kalin, J. H., A Cole, P., Lassalle, D., Forde-Thomas, J., Chalmers, I. W., Brancale, A., Grunau, C. & Hoffmann, K. F., figshare, 05 Maw 2023
Dangosydd eitem ddigidol (DOI): 10.6084/m9.figshare.21814710
Set ddata
Ffeil -
WormassayGP2
Padalino, G. & Pagliuca, G., Zenodo, 03 Gorff 2020
Dangosydd eitem ddigidol (DOI): 10.5281/zenodo.3929417, https://zenodo.org/record/3929417
Set ddata
Ffeil -
Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities - Underlying data
Padalino, G., Chalmers, I. W., Brancale, A. & Hoffmann, K., figshare, 23 Meh 2020
Dangosydd eitem ddigidol (DOI): 10.6084/m9.figshare.12473108, https://figshare.com/articles/Identification_of_6-_piperazin-1-yl_-1_3_5-triazine_as_a_chemical_scaffold_with_broad_anti-schistosomal_activities/12473108
Set ddata
Ffeil -
Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary tables and movies
Padalino, G., Celatka, C. A., Young Rienhoff Jr, H., Kalin, J. H., Cole, P. A., Lassalle, D., Forde-Thomas, J., Chalmers, I. W., Brancale, A., Grunau, C. & Hoffmann, K. F., figshare, 04 Ion 2023
Dangosydd eitem ddigidol (DOI): 10.6084/m9.figshare.21814623
Set ddata
Ffeil