2-Nitroimidazol-5-ylmethyl as a potential bioreductively activated prodrug system: reductively triggered release of the parp inhibitor 5-bromoisoquinolinone

Ifat Shah, Declan P. Naughton, William J. D. Whish, Michael D. Threadgill

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

58 Dyfyniadau(SciVal)

Crynodeb

5-Chloromethyl-1-methyl-2-nitroimidazole reacted efficiently with the anion derived from 5-bromo-isoquinolin-1-one to give 5-bromo-2-((1-methyl-2-nitroimidazol-5-yl)methyl)isoquinolin-1-one. Biomimetic reduction effected release of the 5-bromoisoquinolin-1-one. The 2-nitroimidazol-5-ylmethyl unit thus has potential for development as a general prodrug system for selective drug delivery to hypoxic tissues.
Iaith wreiddiolSaesneg
Tudalennau (o-i)2031-2036
Nifer y tudalennau6
CyfnodolynBioorganic and Medicinal Chemistry Letters
Cyfrol9
Rhif cyhoeddi14
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 19 Gorff 1999
Cyhoeddwyd yn allanolIe

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