TY - GEN
T1 - A petri net model of granulomatous inflammation
AU - Albergante, Luca
AU - Timmis, Jon
AU - Andrews, Paul
AU - Beattie, Lynette
AU - Kaye, Paul M.
N1 - Funding Information:
This research is, in part, funded by EPSRC grant number EP/F032749/1 The TRANSIT Programme - Discipline Bridging at the University of York.
PY - 2010
Y1 - 2010
N2 - Leishmania donovani is an obligate intracellular parasite responsible for the systemic disease visceral leishmaniasis. During the course of the disease, the parasite is found in the spleen, liver and bone marrow. Characteristic of the liver immune response to leishmaniasis is a type of inflammation ("ggranulomatous inflammation") that results in the formation of granulomas, structures comprised of an infiltrate of mononuclear cells surrounding a core of infected macrophages. Granulomas help limit the spread of infection and facilitate the killing of parasites. Liver-resident macrophages (Kupffer cells) are able to spontaneously kill many infectious agents, but L. donovani is capable of reproducing inside these cells. Activation of Kupffer cells is required to turn them from host cell to a cell that is able to kill intracellular L. donovani . This process of activation is regulated by cytokines (notably IFNγ) produced by many different types of leukocytes, including natural killer (NK) cells ([1]), CD4+ and CD8+ T cells ([2]), and NKT cells ([3]).
AB - Leishmania donovani is an obligate intracellular parasite responsible for the systemic disease visceral leishmaniasis. During the course of the disease, the parasite is found in the spleen, liver and bone marrow. Characteristic of the liver immune response to leishmaniasis is a type of inflammation ("ggranulomatous inflammation") that results in the formation of granulomas, structures comprised of an infiltrate of mononuclear cells surrounding a core of infected macrophages. Granulomas help limit the spread of infection and facilitate the killing of parasites. Liver-resident macrophages (Kupffer cells) are able to spontaneously kill many infectious agents, but L. donovani is capable of reproducing inside these cells. Activation of Kupffer cells is required to turn them from host cell to a cell that is able to kill intracellular L. donovani . This process of activation is regulated by cytokines (notably IFNγ) produced by many different types of leukocytes, including natural killer (NK) cells ([1]), CD4+ and CD8+ T cells ([2]), and NKT cells ([3]).
UR - http://www.scopus.com/inward/record.url?scp=77955865091&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-14547-6_1
DO - 10.1007/978-3-642-14547-6_1
M3 - Conference Proceeding (Non-Journal item)
AN - SCOPUS:77955865091
SN - 3642145469
SN - 9783642145469
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 1
EP - 3
BT - Artificial Immune Systems - 9th International Conference, ICARIS 2010, Proceedings
T2 - 9th International Conference on Artificial Immune Systems, ICARIS 2010
Y2 - 26 July 2010 through 29 July 2010
ER -