A petri net model of granulomatous inflammation

Luca Albergante*, Jon Timmis, Paul Andrews, Lynette Beattie, Paul M. Kaye

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion CynhadleddTrafodion Cynhadledd (Nid-Cyfnodolyn fathau)


Leishmania donovani is an obligate intracellular parasite responsible for the systemic disease visceral leishmaniasis. During the course of the disease, the parasite is found in the spleen, liver and bone marrow. Characteristic of the liver immune response to leishmaniasis is a type of inflammation ("ggranulomatous inflammation") that results in the formation of granulomas, structures comprised of an infiltrate of mononuclear cells surrounding a core of infected macrophages. Granulomas help limit the spread of infection and facilitate the killing of parasites. Liver-resident macrophages (Kupffer cells) are able to spontaneously kill many infectious agents, but L. donovani is capable of reproducing inside these cells. Activation of Kupffer cells is required to turn them from host cell to a cell that is able to kill intracellular L. donovani . This process of activation is regulated by cytokines (notably IFNγ) produced by many different types of leukocytes, including natural killer (NK) cells ([1]), CD4+ and CD8+ T cells ([2]), and NKT cells ([3]).

Iaith wreiddiolSaesneg
TeitlArtificial Immune Systems - 9th International Conference, ICARIS 2010, Proceedings
Nifer y tudalennau3
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 2010
Digwyddiad9th International Conference on Artificial Immune Systems, ICARIS 2010 - Edinburgh, Teyrnas Unedig Prydain Fawr a Gogledd Iwerddon
Hyd: 26 Gorff 201029 Gorff 2010

Cyfres gyhoeddiadau

EnwLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Cyfrol6209 LNCS
ISSN (Argraffiad)0302-9743
ISSN (Electronig)1611-3349


Cynhadledd9th International Conference on Artificial Immune Systems, ICARIS 2010
Gwlad/TiriogaethTeyrnas Unedig Prydain Fawr a Gogledd Iwerddon
Cyfnod26 Gorff 201029 Gorff 2010

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