TY - JOUR
T1 - Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders
AU - Zabegalov, Konstantin N.
AU - Khatsko, Sergey L.
AU - Lakstygal, Anton M.
AU - Demin, Konstantin A.
AU - Cleal, Madeleine
AU - Fontana, Barbara D.
AU - McBride, Sebastian
AU - Harvey, Brian
AU - de Abreu, Murilo S.
AU - Parker, Matthew O.
AU - Kalueff, Allan V.
N1 - Funding Information:
KAD is supported by the RFBR grant 18-34-00996 and Special Rector’s Fellowship for SPbSU PhD students. BHH is supported by the South African Medical Research Council (SAMRC) . AVK is the Chair of the International Zebrafish Neuroscience Consortium (ZNRC) that coordinated this multi-laboratory collaborative project. He thanks his laboratory members, and also an anonymous landscape company in New Orleans (mowing his lawn for free for 10 years), collectively enabling a better focus on zebrafish neuroscience research. The authors have no other roles or financial involvement with any organization or entity with a financial interest in, or financial conflict with, the subject matter or materials discussed in the manuscript apart from those disclosed.
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/7/23
Y1 - 2019/7/23
N2 - Abnormal repetitive behaviors (ARBs) are a prominent symptom of numerous human brain disorders and are commonly seen in rodent models as well. While rodent studies of ARBs continue to dominate the field, mounting evidence suggests that zebrafish (Danio rerio) also display ARB-like phenotypes and may therefore be a novel model organism for ARB research. In addition to clear practical research advantages as a model species, zebrafish share high genetic and physiological homology to humans and rodents, including multiple ARB-related genes and robust behaviors relevant to ARB. Here, we discuss a wide spectrum of stereotypic repetitive behaviors in zebrafish, data on their genetic and pharmacological modulation, and the overall translational relevance of fish ARBs to modeling human brain disorders. Overall, the zebrafish is rapidly emerging as a new promising model to study ARBs and their underlying mechanisms.
AB - Abnormal repetitive behaviors (ARBs) are a prominent symptom of numerous human brain disorders and are commonly seen in rodent models as well. While rodent studies of ARBs continue to dominate the field, mounting evidence suggests that zebrafish (Danio rerio) also display ARB-like phenotypes and may therefore be a novel model organism for ARB research. In addition to clear practical research advantages as a model species, zebrafish share high genetic and physiological homology to humans and rodents, including multiple ARB-related genes and robust behaviors relevant to ARB. Here, we discuss a wide spectrum of stereotypic repetitive behaviors in zebrafish, data on their genetic and pharmacological modulation, and the overall translational relevance of fish ARBs to modeling human brain disorders. Overall, the zebrafish is rapidly emerging as a new promising model to study ARBs and their underlying mechanisms.
KW - zebrafish
KW - abnormal repetitive behavior
KW - stereotypy
KW - animal models
KW - human brain disorders
KW - Animal models
KW - Human brain disorders
KW - Zebrafish
KW - Stereotypy
KW - Abnormal repetitive behavior
KW - Humans
KW - Stereotypic Movement Disorder/genetics
KW - Animals
KW - Zebrafish/physiology
KW - Behavior, Animal/physiology
KW - Cognitive Dysfunction/genetics
KW - Executive Function/physiology
KW - Obsessive-Compulsive Disorder/genetics
KW - Disease Models, Animal
KW - Neurodevelopmental Disorders/genetics
UR - https://www.scopus.com/pages/publications/85063763435
U2 - 10.1016/j.bbr.2019.03.044
DO - 10.1016/j.bbr.2019.03.044
M3 - Review Article
C2 - 30926483
SN - 0166-4328
VL - 367
SP - 101
EP - 110
JO - Behavioural Brain Research
JF - Behavioural Brain Research
ER -