Prosiectau fesul blwyddyn
Crynodeb
It is a common practice in the atomic force microscopy (AFM)based studies of living cells to differentiate them by values of the elastic (Young's) modulus, which is supposed to be an effective characteristic of the mechanical properties of a cell as a heterogeneous matter. The elastic response of a cell to AFM indentation is known to be affected by a relative distance from an AFM probe to a solid support on to which the cell is cultured. Besides this socalled bottom effect, AFM measurements may carry significant information regarding the effect of molecular brushes covering living cells. Here, we develop a mathematical model for determining the intrinsic effective Young's modulus of a single brushcoated cell from the forceindentation curve with the bottom effect taken into account. The mathematical model is illustrated with the example of AFM data on testing of an eukaryotic cell taken from the literature.
Iaith wreiddiol  Saesneg 

Tudalennau (oi)  48914898 
Nifer y tudalennau  8 
Cyfnodolyn  Soft Matter 
Cyfrol  19 
Rhif cyhoeddi  26 
Dyddiad arlein cynnar  20 Meh 2023 
Dynodwyr Gwrthrych Digidol (DOIs)  
Statws  Cyhoeddwyd  05 Gorff 2023 
Ôl bys
Gweld gwybodaeth am bynciau ymchwil 'AFMbased spherical indentation of a brushcoated soft material: Modeling the bottom effect'. Gyda’i gilydd, maen nhw’n ffurfio ôl bys unigryw.Prosiectau
 2 Wedi Gorffen

Wolfson Visiting Fellowship  Professor Victor Eremeyev
01 Gorff 2021 → 30 Meh 2023
Prosiect: Ymchwil a ariannwyd yn allanol

Ser Cymru IFA  Development of the tip element to account for singular physical fields near the crack tip and various propagation regimes.
01 Gorff 2020 → 30 Meh 2021
Prosiect: Ymchwil a ariannwyd yn allanol