Alkaloids inhibiting l-histidine decarboxylase from Sinomenium acutum

A. Kato, M. Yasui, N. Yano, Y. Kawata, K. Moriki, I. Adachi, J. Hollinshead, R. J. Nash

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

16 Dyfyniadau(SciVal)

Crynodeb

Chromatographic separation of an extract of the stems of Sinomenium acutum resulted in the isolation of two new alkaloids, 2-O-demethyl-acutumine (4), and 6-O-methyl-laudanosoline-1-O-glucoside (5), together with three known alkaloids, sinomenine (1), sinomenine N-oxide (2), and magnoflorine (3). Sinomenine was found to show good inhibitory activity toward l-histidine decarboxylase from Lactobacillus 30a with an IC50 value of 969 μM but its N-oxide showed no inhibition of this enzyme. Sinomenine inhibited this enzyme in a noncompetitive manner with a Ki of 762 μM.
Iaith wreiddiolSaesneg
Tudalennau (o-i)77-80
Nifer y tudalennau4
CyfnodolynPhytochemistry Letters
Cyfrol2
Rhif cyhoeddi2
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 2009

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