TY - JOUR
T1 - Alkaloids inhibiting l-histidine decarboxylase from Sinomenium acutum
AU - Kato, A.
AU - Yasui, M.
AU - Yano, N.
AU - Kawata, Y.
AU - Moriki, K.
AU - Adachi, I.
AU - Hollinshead, J.
AU - Nash, R. J.
N1 - IMPF: 00.96
RONO: 00
PY - 2009
Y1 - 2009
N2 - Chromatographic separation of an extract of the stems of Sinomenium acutum resulted in the isolation of two new alkaloids, 2-O-demethyl-acutumine (4), and 6-O-methyl-laudanosoline-1-O-glucoside (5), together with three known alkaloids, sinomenine (1), sinomenine N-oxide (2), and magnoflorine (3). Sinomenine was found to show good inhibitory activity toward l-histidine decarboxylase from Lactobacillus 30a with an IC50 value of 969 μM but its N-oxide showed no inhibition of this enzyme. Sinomenine inhibited this enzyme in a noncompetitive manner with a Ki of 762 μM.
AB - Chromatographic separation of an extract of the stems of Sinomenium acutum resulted in the isolation of two new alkaloids, 2-O-demethyl-acutumine (4), and 6-O-methyl-laudanosoline-1-O-glucoside (5), together with three known alkaloids, sinomenine (1), sinomenine N-oxide (2), and magnoflorine (3). Sinomenine was found to show good inhibitory activity toward l-histidine decarboxylase from Lactobacillus 30a with an IC50 value of 969 μM but its N-oxide showed no inhibition of this enzyme. Sinomenine inhibited this enzyme in a noncompetitive manner with a Ki of 762 μM.
UR - http://hdl.handle.net/2160/8033
U2 - 10.1016/j.phytol.2008.12.003
DO - 10.1016/j.phytol.2008.12.003
M3 - Article
SN - 1876-7486
VL - 2
SP - 77
EP - 80
JO - Phytochemistry Letters
JF - Phytochemistry Letters
IS - 2
ER -