An Analytical Pipeline for Quantitative Characterization of Dietary Intake: Application To Assess Grape Intake

Isabel Garcia-Perez, Joram M Posma, Edward S. Chambers, Jeremy K. Nicholson, John C. Mathers, Manfred Beckmann, John Draper, Elaine Holmes, Gary Frost

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

182 Wedi eu Llwytho i Lawr (Pure)

Crynodeb

Lack of accurate dietary assessment in free-living populations requires discovery of new biomarkers reflecting food intake qualitatively and quantitatively to objectively evaluate effects of diet on health. We provide a proof-of-principle for an analytical pipeline to identify quantitative dietary biomarkers. Tartaric acid was identified by nuclear magnetic resonance spectroscopy as a dose-responsive urinary biomarker of grape intake and subsequently quantified in volunteers following a series of 4-day dietary interventions incorporating 0 g/day, 50 g/day, 100 g/day, and 150 g/day of grapes in standardized diets from a randomized controlled clinical trial. Most accurate quantitative predictions of grape intake were obtained in 24 h urine samples which have the strongest linear relationship between grape intake and tartaric acid excretion (r(2) = 0.90). This new methodological pipeline for estimating nutritional intake based on coupling dietary intake information and quantified nutritional biomarkers was developed and validated in a controlled dietary intervention study, showing that this approach can improve the accuracy of estimating nutritional intakes.

Iaith wreiddiolSaesneg
Tudalennau (o-i)2423-2431
Nifer y tudalennau9
CyfnodolynJournal of Agricultural and Food Chemistry
Cyfrol64
Rhif cyhoeddi11
Dyddiad ar-lein cynnar24 Chwef 2016
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 23 Maw 2016

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