An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum

Liam Evans; John N. Hedger; David Brayford; Michael Stavri; Eileen Smith; Gemma O'Donnell; Alexander I. Gray; Gareth W. Griffith; Simon Gibbons

doi:10.1016/j.phytochem.2006.06.033

An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum

Liam Evans, John N. Hedger, David Brayford, Michael Stavri, Eileen Smith, Gemma O'Donnell, Alexander I. Gray, Gareth W. Griffith, Simon Gibbons

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A fusidane triterpene, 16-deacetoxy-7-β-hydroxy-fusidic acid (1), was isolated from a fermentation of the mitosporic fungus Acremonium crotocinigenum. Full unambiguous assignment of all 1H and 13C data of 1 was carried out by extensive one- and two-dimensional NMR studies employing HMQC and HMBC spectra. Compound 1 was tested against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains and showed minimum inhibitory concentration values of 16 μg/ml. Bioautography-led isolation of an extract of the fermentation of the mitosporic fungus Acremonium crotocinigenum resulted in the characterisation of the fusidane triterpene related to fusidic acid, 1, as the major anti-staphylococcal natural product. Against efflux strains, 1 had MIC values of 16 μg/ml.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	2110-2114
Nifer y tudalennau	5
Cyfnodolyn	Phytochemistry
Cyfrol	67
Rhif cyhoeddi	19
Dyddiad ar-lein cynnar	22 Awst 2006
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1016/j.phytochem.2006.06.033
Statws	Cyhoeddwyd - 01 Hyd 2006

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10.1016/j.phytochem.2006.06.033

http://hdl.handle.net/2160/2695

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@article{a8dfe55edcfc4d7f9d3d267d7cb33f03,

title = "An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum",

abstract = "A fusidane triterpene, 16-deacetoxy-7-β-hydroxy-fusidic acid (1), was isolated from a fermentation of the mitosporic fungus Acremonium crotocinigenum. Full unambiguous assignment of all 1H and 13C data of 1 was carried out by extensive one- and two-dimensional NMR studies employing HMQC and HMBC spectra. Compound 1 was tested against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains and showed minimum inhibitory concentration values of 16 μg/ml. Bioautography-led isolation of an extract of the fermentation of the mitosporic fungus Acremonium crotocinigenum resulted in the characterisation of the fusidane triterpene related to fusidic acid, 1, as the major anti-staphylococcal natural product. Against efflux strains, 1 had MIC values of 16 μg/ml.",

keywords = "Acrmonium crotocinigenum, Fusidane triterpene, fusidic acid, antibacterial, MRSA, MDR, Staphylococcus aureus",

author = "Liam Evans and Hedger, {John N.} and David Brayford and Michael Stavri and Eileen Smith and Gemma O'Donnell and Gray, {Alexander I.} and Griffith, {Gareth W.} and Simon Gibbons",

note = "Evans, L., Hedger, J. N., Brayford, D., Stavri, M., Smith, E., O'Donnell, G., Gray, A. I., Griffith,. G. W., Gibbons, S. (2006).. An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum . Phytochemistry, 67, (19), 2110-2114. Keywords: Acremonium crotocinigenum; Fusidane triterpene; Fusidic acid; Antibacterial; MRSA; MDR; Staphylococcus aureus Sponsorship: EPSRC (Grant No. GR/R47646/01)",

year = "2006",

month = oct,

day = "1",

doi = "10.1016/j.phytochem.2006.06.033",

language = "English",

volume = "67",

pages = "2110--2114",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier",

number = "19",

}

TY - JOUR

T1 - An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum

AU - Evans, Liam

AU - Hedger, John N.

AU - Brayford, David

AU - Stavri, Michael

AU - Smith, Eileen

AU - O'Donnell, Gemma

AU - Gray, Alexander I.

AU - Griffith, Gareth W.

AU - Gibbons, Simon

N1 - Evans, L., Hedger, J. N., Brayford, D., Stavri, M., Smith, E., O'Donnell, G., Gray, A. I., Griffith,. G. W., Gibbons, S. (2006).. An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum . Phytochemistry, 67, (19), 2110-2114. Keywords: Acremonium crotocinigenum; Fusidane triterpene; Fusidic acid; Antibacterial; MRSA; MDR; Staphylococcus aureus Sponsorship: EPSRC (Grant No. GR/R47646/01)

PY - 2006/10/1

Y1 - 2006/10/1

N2 - A fusidane triterpene, 16-deacetoxy-7-β-hydroxy-fusidic acid (1), was isolated from a fermentation of the mitosporic fungus Acremonium crotocinigenum. Full unambiguous assignment of all 1H and 13C data of 1 was carried out by extensive one- and two-dimensional NMR studies employing HMQC and HMBC spectra. Compound 1 was tested against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains and showed minimum inhibitory concentration values of 16 μg/ml. Bioautography-led isolation of an extract of the fermentation of the mitosporic fungus Acremonium crotocinigenum resulted in the characterisation of the fusidane triterpene related to fusidic acid, 1, as the major anti-staphylococcal natural product. Against efflux strains, 1 had MIC values of 16 μg/ml.

AB - A fusidane triterpene, 16-deacetoxy-7-β-hydroxy-fusidic acid (1), was isolated from a fermentation of the mitosporic fungus Acremonium crotocinigenum. Full unambiguous assignment of all 1H and 13C data of 1 was carried out by extensive one- and two-dimensional NMR studies employing HMQC and HMBC spectra. Compound 1 was tested against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains and showed minimum inhibitory concentration values of 16 μg/ml. Bioautography-led isolation of an extract of the fermentation of the mitosporic fungus Acremonium crotocinigenum resulted in the characterisation of the fusidane triterpene related to fusidic acid, 1, as the major anti-staphylococcal natural product. Against efflux strains, 1 had MIC values of 16 μg/ml.

KW - Acrmonium crotocinigenum

KW - Fusidane triterpene

KW - fusidic acid

KW - antibacterial

KW - MRSA

KW - MDR

KW - Staphylococcus aureus

U2 - 10.1016/j.phytochem.2006.06.033

DO - 10.1016/j.phytochem.2006.06.033

M3 - Article

C2 - 16930645

SN - 0031-9422

VL - 67

SP - 2110

EP - 2114

JO - Phytochemistry

JF - Phytochemistry

IS - 19

ER -

An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum

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