An Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies

Giorgia Perri; Chloe French; César Agostinis-Sobrinho; Atul Anand; Radiana Dhewayani Antarianto; Yasumichi Arai; Joseph A Baur; Omar Cauli; Morgane Clivaz-Duc; Giuseppe Colloca; Constantinos Demetriades; Chiara de Lucia; Giorgio Di Gessa; Breno S Diniz; Catherine L Dotchin; Gillian Eaglestone; Bradley T Elliott; Mark A Espeland; Luigi Ferrucci; James Fisher; Dimitris K Grammatopoulos; Novi S Hardiany; Zaki Hassan-Smith; Waylon J Hastings; Swati Jain; Peter K Joshi; Theodora Katsila; Graham J Kemp; Omid A Khaiyat; Dudley W Lamming; Jose Lara Gallegos; Frank Madeo; Andrea B Maier; Carmen Martin-Ruiz; Ian J Martins; John C Mathers; Lewis R Mattin; Reshma A Merchant; Alexey Moskalev; Ognian Neytchev; Mary Ni Lochlainn; Claire M Owen; Stuart M Phillips; Jedd Pratt; Konstantinos Prokopidis; Nicholas J W Rattray; María Rúa-Alonso; Lutz Schomburg; David Scott; Sangeetha Shyam; Elina Sillanpää; Michelle M C Tan; Ruth Teh; Stephanie W Tobin; Carolina J Vila-Chã; Luigi Vorluni; Daniela Weber; Ailsa Welch; Daisy Wilson; Thomas Wilson; Tongbiao Zhao; Elena Philippou; Viktor I Korolchuk; Oliver M Shannon

doi:10.1093/gerona/glae297

An Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies

Giorgia Perri^*
, Chloe French
, César Agostinis-Sobrinho
, Atul Anand
, Radiana Dhewayani Antarianto
, Yasumichi Arai
, Joseph A Baur
, Omar Cauli
, Morgane Clivaz-Duc
, Giuseppe Colloca
, Constantinos Demetriades
, Chiara de Lucia
, Giorgio Di Gessa
, Breno S Diniz
, Catherine L Dotchin
, Gillian Eaglestone
, Bradley T Elliott
, Mark A Espeland
, Luigi Ferrucci
, James Fisher

Dimitris K Grammatopoulos, Novi S Hardiany, Zaki Hassan-Smith, Waylon J Hastings, Swati Jain, Peter K Joshi, Theodora Katsila, Graham J Kemp, Omid A Khaiyat, Dudley W Lamming, Jose Lara Gallegos, Frank Madeo, Andrea B Maier, Carmen Martin-Ruiz, Ian J Martins, John C Mathers, Lewis R Mattin, Reshma A Merchant, Alexey Moskalev, Ognian Neytchev, Mary Ni Lochlainn, Claire M Owen, Stuart M Phillips, Jedd Pratt, Konstantinos Prokopidis, Nicholas J W Rattray, María Rúa-Alonso, Lutz Schomburg, David Scott, Sangeetha Shyam, Elina Sillanpää, Michelle M C Tan, Ruth Teh, Stephanie W Tobin, Carolina J Vila-Chã, Luigi Vorluni, Daniela Weber, Ailsa Welch, Daisy Wilson, Thomas Wilson, Tongbiao Zhao, Elena Philippou, Viktor I Korolchuk, Oliver M Shannon

^*Awdur cyfatebol y gwaith hwn

Athrofa'r Gwyddorau Biolegol, Amgylcheddol a Gwledig

University of Newcastle Australia
University of Manchester
Klaipėda University
Sport Physical Activity and Health Research & Innovation Center (SPRINT)
University of Edinburgh
University of Indonesia
Keio University
University of Pennsylvania
Universitat de València
CareConnex
Agostino Gemelli University Polyclinic
University of Cologne
Max Planck Institute for Biology of Ageing
King's College London
Stavanger University Hospital
University College London
University of Connecticut
Northumbria Healthcare NHS Foundation Trust
University of Greenwich
University of Westminster
Wake Forest University
National Institutes of Health
University Hospital Coventry
University of Warwick
University Hospitals Birmingham NHS Foundation Trust
University of Birmingham
Texas A&M University
Association of State Public Health Nutritionists
Humanity Inc
National Hellenic Research Foundation
University of Liverpool
Liverpool Hope University
University of Wisconsin Carbone Cancer Center
Northumbria University
University of Graz
National University Health System
National University of Singapore
Edith Cowan University
Clinical Research Management
N. I. Lobachevsky State University of Nizhny Novgorod
University of Glasgow
McMaster University
Metropolitan University
University of Strathclyde
Universidade da Coruña
Charité - Universitätsmedizin Berlin
Monash University
Deakin University
Instituto de Salud Carlos III
Universitat Rovira i Virgili
Wellbeing Services County of Central Finland
University of Jyväskylä
University of Auckland
Trent University
Independent Researcher and Technical Consultant
German Institute of Human Nutrition
University of East Anglia
Chinese Academy of Sciences
University of Nicosia

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

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Biomarkers of aging serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of aging for use in intervention studies via the Delphi method. A 3-round Delphi study was conducted using an online platform. In Round 1, expert panel members provided suggestions for candidate biomarkers of aging. In Rounds 2 and 3, they voted on 500 initial statements (yes/no) relating to 20 biomarkers of aging. Panel members could abstain from voting on biomarkers outside their expertise. Consensus was reached when there was ≥70% agreement on a statement/biomarker. Of the 460 international panel members invited to participate, 116 completed Round 1, 87 completed Round 2, and 60 completed Round 3. Across the 3 rounds, 14 biomarkers met consensus that spanned physiological (eg, insulin-like growth factor 1, growth-differentiating factor-15), inflammatory (eg, high sensitivity C-reactive protein, interleukin-6), functional (eg, muscle mass, muscle strength, hand grip strength, Timed-Up-and-Go, gait speed, standing balance test, frailty index, cognitive health, blood pressure), and epigenetic (eg, DNA methylation/epigenetic clocks) domains. Expert consensus identified 14 potential biomarkers of aging which may be used as outcome measures in intervention studies. Future aging research should identify which combination of these biomarkers has the greatest utility.

Iaith wreiddiol	Saesneg
Rhif yr erthygl	glae297
Nifer y tudalennau	12
Cyfnodolyn	The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences
Cyfrol	80
Rhif cyhoeddi	5
Dyddiad ar-lein cynnar	21 Rhag 2024
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1093/gerona/glae297 https://doi.org/10.1093/gerona/glae297
Statws	Cyhoeddwyd - 31 Mai 2025

NDC y CU

Mae’r allbwn hwn yn cyfrannu at y Nod(au) Datblygu Cynaliadwy canlynol

NDC 3 Iechyd a Llesiant Da

Mynediad at Ddogfen

10.1093/gerona/glae297Trwydded: CC BY
10.1093/gerona/glae297

ArticleFersiwn derfynol wedi’i chyhoeddi, 1.21 MBTrwydded: CC BY
Supplementary dataData, 784 KBTrwydded: CC BY

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Perri, G., French, C., Agostinis-Sobrinho, C., Anand, A., Antarianto, R. D., Arai, Y., Baur, J. A., Cauli, O., Clivaz-Duc, M., Colloca, G., Demetriades, C., de Lucia, C., Di Gessa, G., Diniz, B. S., Dotchin, C. L., Eaglestone, G., Elliott, B. T., Espeland, M. A., Ferrucci, L., ... Shannon, O. M. (2025). An Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 80(5), erthygl glae297. https://doi.org/10.1093/gerona/glae297, https://doi.org/10.1093/gerona/glae297

@article{6e9d10d04d7f47899fd2a1311637cfab,

title = "An Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies",

abstract = "Biomarkers of aging serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of aging for use in intervention studies via the Delphi method. A 3-round Delphi study was conducted using an online platform. In Round 1, expert panel members provided suggestions for candidate biomarkers of aging. In Rounds 2 and 3, they voted on 500 initial statements (yes/no) relating to 20 biomarkers of aging. Panel members could abstain from voting on biomarkers outside their expertise. Consensus was reached when there was ≥70\% agreement on a statement/biomarker. Of the 460 international panel members invited to participate, 116 completed Round 1, 87 completed Round 2, and 60 completed Round 3. Across the 3 rounds, 14 biomarkers met consensus that spanned physiological (eg, insulin-like growth factor 1, growth-differentiating factor-15), inflammatory (eg, high sensitivity C-reactive protein, interleukin-6), functional (eg, muscle mass, muscle strength, hand grip strength, Timed-Up-and-Go, gait speed, standing balance test, frailty index, cognitive health, blood pressure), and epigenetic (eg, DNA methylation/epigenetic clocks) domains. Expert consensus identified 14 potential biomarkers of aging which may be used as outcome measures in intervention studies. Future aging research should identify which combination of these biomarkers has the greatest utility.",

keywords = "Consensus, Delphi method, Longevity, Aging/physiology, Delphi Technique, Humans, Biomarkers/analysis, Aged",

author = "Giorgia Perri and Chloe French and C{\'e}sar Agostinis-Sobrinho and Atul Anand and Antarianto, \{Radiana Dhewayani\} and Yasumichi Arai and Baur, \{Joseph A\} and Omar Cauli and Morgane Clivaz-Duc and Giuseppe Colloca and Constantinos Demetriades and \{de Lucia\}, Chiara and \{Di Gessa\}, Giorgio and Diniz, \{Breno S\} and Dotchin, \{Catherine L\} and Gillian Eaglestone and Elliott, \{Bradley T\} and Espeland, \{Mark A\} and Luigi Ferrucci and James Fisher and Grammatopoulos, \{Dimitris K\} and Hardiany, \{Novi S\} and Zaki Hassan-Smith and Hastings, \{Waylon J\} and Swati Jain and Joshi, \{Peter K\} and Theodora Katsila and Kemp, \{Graham J\} and Khaiyat, \{Omid A\} and Lamming, \{Dudley W\} and Gallegos, \{Jose Lara\} and Frank Madeo and Maier, \{Andrea B\} and Carmen Martin-Ruiz and Martins, \{Ian J\} and Mathers, \{John C\} and Mattin, \{Lewis R\} and Merchant, \{Reshma A\} and Alexey Moskalev and Ognian Neytchev and \{Ni Lochlainn\}, Mary and Owen, \{Claire M\} and Phillips, \{Stuart M\} and Jedd Pratt and Konstantinos Prokopidis and Rattray, \{Nicholas J W\} and Mar{\'i}a R{\'u}a-Alonso and Lutz Schomburg and David Scott and Sangeetha Shyam and Elina Sillanp{\"a}{\"a} and Tan, \{Michelle M C\} and Ruth Teh and Tobin, \{Stephanie W\} and Vila-Ch{\~a}, \{Carolina J\} and Luigi Vorluni and Daniela Weber and Ailsa Welch and Daisy Wilson and Thomas Wilson and Tongbiao Zhao and Elena Philippou and Korolchuk, \{Viktor I\} and Shannon, \{Oliver M\}",

note = "{\textcopyright} The Author(s) 2024. Published by Oxford University Press on behalf of the Gerontological Society of America.",

year = "2025",

month = may,

day = "31",

doi = "10.1093/gerona/glae297",

language = "English",

volume = "80",

journal = "The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences",

issn = "1079-5006",

publisher = "Oxford University Press",

number = "5",

}

Perri, G, French, C, Agostinis-Sobrinho, C, Anand, A, Antarianto, RD, Arai, Y, Baur, JA, Cauli, O, Clivaz-Duc, M, Colloca, G, Demetriades, C, de Lucia, C, Di Gessa, G, Diniz, BS, Dotchin, CL, Eaglestone, G, Elliott, BT, Espeland, MA, Ferrucci, L, Fisher, J, Grammatopoulos, DK, Hardiany, NS, Hassan-Smith, Z, Hastings, WJ, Jain, S, Joshi, PK, Katsila, T, Kemp, GJ, Khaiyat, OA, Lamming, DW, Gallegos, JL, Madeo, F, Maier, AB, Martin-Ruiz, C, Martins, IJ, Mathers, JC, Mattin, LR, Merchant, RA, Moskalev, A, Neytchev, O, Ni Lochlainn, M, Owen, CM, Phillips, SM, Pratt, J, Prokopidis, K, Rattray, NJW, Rúa-Alonso, M, Schomburg, L, Scott, D, Shyam, S, Sillanpää, E, Tan, MMC, Teh, R, Tobin, SW, Vila-Chã, CJ, Vorluni, L, Weber, D, Welch, A, Wilson, D, Wilson, T, Zhao, T, Philippou, E, Korolchuk, VI & Shannon, OM 2025, 'An Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies', The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, cyfrol. 80, rhif 5, glae297. https://doi.org/10.1093/gerona/glae297, https://doi.org/10.1093/gerona/glae297

TY - JOUR

T1 - An Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies

AU - Perri, Giorgia

AU - French, Chloe

AU - Agostinis-Sobrinho, César

AU - Anand, Atul

AU - Antarianto, Radiana Dhewayani

AU - Arai, Yasumichi

AU - Baur, Joseph A

AU - Cauli, Omar

AU - Clivaz-Duc, Morgane

AU - Colloca, Giuseppe

AU - Demetriades, Constantinos

AU - de Lucia, Chiara

AU - Di Gessa, Giorgio

AU - Diniz, Breno S

AU - Dotchin, Catherine L

AU - Eaglestone, Gillian

AU - Elliott, Bradley T

AU - Espeland, Mark A

AU - Ferrucci, Luigi

AU - Fisher, James

AU - Grammatopoulos, Dimitris K

AU - Hardiany, Novi S

AU - Hassan-Smith, Zaki

AU - Hastings, Waylon J

AU - Jain, Swati

AU - Joshi, Peter K

AU - Katsila, Theodora

AU - Kemp, Graham J

AU - Khaiyat, Omid A

AU - Lamming, Dudley W

AU - Gallegos, Jose Lara

AU - Madeo, Frank

AU - Maier, Andrea B

AU - Martin-Ruiz, Carmen

AU - Martins, Ian J

AU - Mathers, John C

AU - Mattin, Lewis R

AU - Merchant, Reshma A

AU - Moskalev, Alexey

AU - Neytchev, Ognian

AU - Ni Lochlainn, Mary

AU - Owen, Claire M

AU - Phillips, Stuart M

AU - Pratt, Jedd

AU - Prokopidis, Konstantinos

AU - Rattray, Nicholas J W

AU - Rúa-Alonso, María

AU - Schomburg, Lutz

AU - Scott, David

AU - Shyam, Sangeetha

AU - Sillanpää, Elina

AU - Tan, Michelle M C

AU - Teh, Ruth

AU - Tobin, Stephanie W

AU - Vila-Chã, Carolina J

AU - Vorluni, Luigi

AU - Weber, Daniela

AU - Welch, Ailsa

AU - Wilson, Daisy

AU - Wilson, Thomas

AU - Zhao, Tongbiao

AU - Philippou, Elena

AU - Korolchuk, Viktor I

AU - Shannon, Oliver M

PY - 2025/5/31

Y1 - 2025/5/31

N2 - Biomarkers of aging serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of aging for use in intervention studies via the Delphi method. A 3-round Delphi study was conducted using an online platform. In Round 1, expert panel members provided suggestions for candidate biomarkers of aging. In Rounds 2 and 3, they voted on 500 initial statements (yes/no) relating to 20 biomarkers of aging. Panel members could abstain from voting on biomarkers outside their expertise. Consensus was reached when there was ≥70% agreement on a statement/biomarker. Of the 460 international panel members invited to participate, 116 completed Round 1, 87 completed Round 2, and 60 completed Round 3. Across the 3 rounds, 14 biomarkers met consensus that spanned physiological (eg, insulin-like growth factor 1, growth-differentiating factor-15), inflammatory (eg, high sensitivity C-reactive protein, interleukin-6), functional (eg, muscle mass, muscle strength, hand grip strength, Timed-Up-and-Go, gait speed, standing balance test, frailty index, cognitive health, blood pressure), and epigenetic (eg, DNA methylation/epigenetic clocks) domains. Expert consensus identified 14 potential biomarkers of aging which may be used as outcome measures in intervention studies. Future aging research should identify which combination of these biomarkers has the greatest utility.

AB - Biomarkers of aging serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of aging for use in intervention studies via the Delphi method. A 3-round Delphi study was conducted using an online platform. In Round 1, expert panel members provided suggestions for candidate biomarkers of aging. In Rounds 2 and 3, they voted on 500 initial statements (yes/no) relating to 20 biomarkers of aging. Panel members could abstain from voting on biomarkers outside their expertise. Consensus was reached when there was ≥70% agreement on a statement/biomarker. Of the 460 international panel members invited to participate, 116 completed Round 1, 87 completed Round 2, and 60 completed Round 3. Across the 3 rounds, 14 biomarkers met consensus that spanned physiological (eg, insulin-like growth factor 1, growth-differentiating factor-15), inflammatory (eg, high sensitivity C-reactive protein, interleukin-6), functional (eg, muscle mass, muscle strength, hand grip strength, Timed-Up-and-Go, gait speed, standing balance test, frailty index, cognitive health, blood pressure), and epigenetic (eg, DNA methylation/epigenetic clocks) domains. Expert consensus identified 14 potential biomarkers of aging which may be used as outcome measures in intervention studies. Future aging research should identify which combination of these biomarkers has the greatest utility.

KW - Consensus

KW - Delphi method

KW - Longevity

KW - Aging/physiology

KW - Delphi Technique

KW - Humans

KW - Biomarkers/analysis

KW - Aged

UR - https://www.scopus.com/pages/publications/105003168957

U2 - 10.1093/gerona/glae297

DO - 10.1093/gerona/glae297

M3 - Article

C2 - 39708300

SN - 1079-5006

VL - 80

JO - The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

JF - The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

IS - 5

M1 - glae297

ER -

An Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies

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