TY - JOUR
T1 - Analyses of pig genomes provide insight into porcine demography and evolution
AU - Groenen, Martien A M
AU - Archibald, Alan L
AU - Uenishi, Hirohide
AU - Tuggle, Christopher K
AU - Takeuchi, Yasuhiro
AU - Rothschild, Max F
AU - Rogel-Gaillard, Claire
AU - Park, Chankyu
AU - Milan, Denis
AU - Megens, Hendrik-Jan
AU - Li, Shengting
AU - Larkin, Denis M
AU - Kim, Heebal
AU - Frantz, Laurent A F
AU - Caccamo, Mario
AU - Ahn, Hyeonju
AU - Aken, Bronwen L
AU - Anselmo, Anna
AU - Anthon, Christian
AU - Auvil, Loretta
AU - Badaoui, Bouabid
AU - Beattie, Craig W
AU - Bendixen, Christian
AU - Berman, Daniel
AU - Blecha, Frank
AU - Blomberg, Jonas
AU - Bolund, Lars
AU - Bosse, Mirte
AU - Botti, Sara
AU - Bujie, Zhan
AU - Bystrom, Megan
AU - Capitanu, Boris
AU - Carvalho-Silva, Denise
AU - Chardon, Patrick
AU - Chen, Celine
AU - Cheng, Ryan
AU - Choi, Sang-Haeng
AU - Chow, William
AU - Clark, Richard C
AU - Clee, Christopher
AU - Crooijmans, Richard P M A
AU - Dawson, Harry D
AU - Dehais, Patrice
AU - De Sapio, Fioravante
AU - Dibbits, Bert
AU - Drou, Nizar
AU - Du, Zhi-Qiang
AU - Eversole, Kellye
AU - Fadista, João
AU - Fairley, Susan
AU - Faraut, Thomas
AU - Faulkner, Geoffrey J
AU - Fowler, Katie E
AU - Fredholm, Merete
AU - Fritz, Eric
AU - Gilbert, James G R
AU - Giuffra, Elisabetta
AU - Gorodkin, Jan
AU - Griffin, Darren K
AU - Harrow, Jennifer L
AU - Hayward, Alexander
AU - Howe, Kerstin
AU - Hu, Zhi-Liang
AU - Humphray, Sean J
AU - Hunt, Toby
AU - Hornshøj, Henrik
AU - Jeon, Jin-Tae
AU - Jern, Patric
AU - Jones, Matthew
AU - Jurka, Jerzy
AU - Kanamori, Hiroyuki
AU - Kapetanovic, Ronan
AU - Kim, Jaebum
AU - Kim, Jae-Hwan
AU - Kim, Kyu-Won
AU - Kim, Tae-Hun
AU - Larson, Greger
AU - Lee, Kyooyeol
AU - Lee, Kyung-Tai
AU - Leggett, Richard
AU - Lewin, Harris A
AU - Li, Yingrui
AU - Liu, Wansheng
AU - Loveland, Jane E
AU - Lu, Yao
AU - Lunney, Joan K
AU - Ma, Jian
AU - Madsen, Ole
AU - Mann, Katherine
AU - Matthews, Lucy
AU - McLaren, Stuart
AU - Morozumi, Takeya
AU - Murtaugh, Michael P
AU - Narayan, Jitendra
AU - Nguyen, Dinh Truong
AU - Ni, Peixiang
AU - Oh, Song-Jung
AU - Onteru, Suneel
AU - Panitz, Frank
AU - Park, Eung-Woo
AU - Park, Hong-Seog
AU - Pascal, Geraldine
AU - Paudel, Yogesh
AU - Perez-Enciso, Miguel
AU - Ramirez-Gonzalez, Ricardo
AU - Reecy, James M
AU - Rodriguez-Zas, Sandra
AU - Rohrer, Gary A
AU - Rund, Lauretta
AU - Sang, Yongming
AU - Schachtschneider, Kyle
AU - Schraiber, Joshua G
AU - Schwartz, John
AU - Scobie, Linda
AU - Scott, Carol
AU - Searle, Stephen
AU - Servin, Bertrand
AU - Southey, Bruce R
AU - Sperber, Goran
AU - Stadler, Peter
AU - Sweedler, Jonathan V
AU - Tafer, Hakim
AU - Thomsen, Bo
AU - Wali, Rashmi
AU - Wang, Jian
AU - Wang, Jun
AU - White, Simon
AU - Xu, Xun
AU - Yerle, Martine
AU - Zhang, Guojie
AU - Zhang, Jianguo
AU - Zhang, Jie
AU - Zhao, Shuhong
AU - Rogers, Jane
AU - Churcher, Carol
AU - Schook, Lawrence B
N1 - Groenen, M. A. M., Archibald, A. L., Uenishi, H., Tuggle, C. K., Takeuchi, Y., Rothschild, M. F., Rogel-Gaillard, C., Park, C., Milan, D., Megens, H-J., Li, S., Larkin, D. M., Kim, H., Frantz, L. A. F., Caccamo, M., Ahn, H., Aken, B. L., Anselmo, A., Anthon, C., Auvil, L., Badaoui, B., Beattie, C. W., Bendixen, C., Berman, D., Blecha, F., Blomberg, J., Bolund, L., Bosse, M., Botti, S., Bujie, Z., Bystrom, M., Capitanu, B., Carvalho-Silva, D., Chardon, P., Chen, C., Cheng, R., Choi, S-H., Chow, W., Clark, R. C., Clee, C., Crooijmans, R. P. M. A., Dawson, H. D., Dehais, P., De Sapio, F., Dibbits, B., Drou, N., Du, Z-Q., Eversole, K., Fadista, J., Fairley, S., Faraut, T., Faulkner, G. J., Fowler, K. E., Fredholm, M., Fritz, E., Gilbert, J. G. R., Giuffra, E., Gorodkin, J., Griffin, D. K., Harrow, J. L., Hayward, A., Howe, K., Hu, Z-L., Humphray, S. J., Hunt, T., Hornshøj, H., Jeon, J-T., Jern, P., Jones, M., Jurka, J., Kanamori, H., Kapetanovic, R., Kim, J., Kim, J-H., Kim, K-W., Kim, T-H., Larson, G., Lee, K., Lee, K-T., Leggett, R., Lewin, H. A., Li, Y., Liu, W., Loveland, J. E., Lu, Y., Lunney, J. K., Ma, J., Madsen, O., Mann, K., Matthews, L., McLaren, S., Morozumi, T., Murtaugh, M. P., Narayan, J., Nguyen, D. T., Ni, P., Oh, S-J., Onteru, S., Panitz, F., Park, E-W., Park, H-S., Pascal, G., Paudel, Y., Perez-Enciso, M., Ramirez-Gonzalez, R., Reecy, J. M., Rodriguez-Zas, S., Rohrer, G. A., Rund, L., Sang, Y., Schachtschneider, K., Schraiber, J. G., Schwartz, J., Scobie, L., Scott, C., Searle, S., Servin, B., Southey, B. R., Sperber, G., Stadler, P., Sweedler, J. V., Tafer, H., Thomsen, B., Wali, R., Wang, J., Wang, J., White, S., Xu, X., Yerle, M., Zhang, G., Zhang, J., Zhang, J., Zhao, S., Rogers, J., Churcher, C., Schook, L. B. (2012). Analyses of pig genomes provide insight into porcine demography and evolution. Nature, 491 (7424), 393-398.
PY - 2012/11/15
Y1 - 2012/11/15
N2 - For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars ∼1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast evolution. Pigs have the largest repertoire of functional olfactory receptor genes, reflecting the importance of smell in this scavenging animal. The pig genome sequence provides an important resource for further improvements of this important livestock species, and our identification of many putative disease-causing variants extends the potential of the pig as a biomedical model.
AB - For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars ∼1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast evolution. Pigs have the largest repertoire of functional olfactory receptor genes, reflecting the importance of smell in this scavenging animal. The pig genome sequence provides an important resource for further improvements of this important livestock species, and our identification of many putative disease-causing variants extends the potential of the pig as a biomedical model.
UR - http://hdl.handle.net/2160/8897
U2 - 10.1038/nature11622
DO - 10.1038/nature11622
M3 - Article
C2 - 23151582
SN - 1476-4687
VL - 491
SP - 393
EP - 398
JO - Nature
JF - Nature
IS - 7424
ER -