Antibody bound to the surface antigen MPB83 of Mycobacterium bovis enhances survival against high dose and low dose challenge

Mark A. Chambers*, Dolores Gavier-Widén, R. Glyn Hewinson

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

56 Dyfyniadau(SciVal)

Crynodeb

Tuberculosis caused by infection with Mycobacterium tuberculosis or Mycobacterium bovis is a significant disease of man and animals. Whilst cellular immunity is the major immunological component required for protection against these organisms, recent reports have suggested that monoclonal antibodies can modify infection with M. tuberculosis. To test whether the same was true for M. bovis infection, we determined the effect of preincubation of M. bovis with a monoclonal antibody on subsequent intravenous infection of mice. Antibodies bound to the surface of M. bovis increased the survival time of mice infected with M. bovis and changed the morphology of granulomas and the distribution of acid-fast bacilli in the lung. These studies suggest that antibodies directed to the surface of virulent mycobacteria can modulate their virulence in vivo.

Iaith wreiddiolSaesneg
Tudalennau (o-i)93-100
Nifer y tudalennau8
CyfnodolynFEMS Immunology and Medical Microbiology
Cyfrol41
Rhif cyhoeddi2
Dyddiad ar-lein cynnar05 Chwef 2004
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 01 Meh 2004

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