Atomic force microscopy-based indentation of cells: Modelling the effect of a pericellular coat

Ivan Argatov, Xiaoqing Jin, Gennady Mishuris*

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

3 Dyfyniadau(SciVal)
93 Wedi eu Llwytho i Lawr (Pure)

Crynodeb

A simple analytical model is built up to account for the interface deformation effect in a spherical atomic force microscopy (AFM)-based quasi-static indentation of a living cell covered with a pericellular brush. The compression behaviour of the pericellular coat is described using the Alexander-de Gennes model that allows for nonlinear deformation. An approximate second-order relation between contact force and indenter displacement is obtained in implicit form, using the Hertzian solution as a first-order approximation. A method of fitting the indentation brush/cell model to experimental data is suggested based on the non-dimensionalized version of the displacement-force relation in the parametric form and illustrated with a specific example of AFM raw data taken from the literature.

Iaith wreiddiolSaesneg
Rhif yr erthygl20220857
Nifer y tudalennau10
CyfnodolynInterface
Cyfrol20
Rhif cyhoeddi199
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 22 Chwef 2023

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