Bottlenecks and broomsticks: The molecular evolution of Mycobacterium bovis

Noel H. Smith, Stephen V. Gordon, Ricardo de la Rua-Domenech, Richard S. Clifton-Hadley, R. Glyn Hewinson*

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl Adolyguadolygiad gan gymheiriaid

268 Dyfyniadau (Scopus)

Crynodeb

Mycobacterium bovis is the cause of tuberculosis in cattle and is a member of the Mycobacterium tuberculosis complex. In contrast to many other pathogenic bacterial species, there is little evidence for the transfer and recombination of genes between cells. The clonality of this group of organisms indicates that the population structure is dominated by reductions in diversity, caused either by population bottlenecks or selective sweeps as entire chromosomes become fixed in the population. We describe how these forces have shaped not only the phylogeny of this group but also, at a very local level, the population structure of Mycobacterium bovis in the British Isles. We also discuss the practical implications of applying this knowledge to understanding the spread of infection and the development of improved vaccines and diagnostic tests.

Iaith wreiddiolSaesneg
Tudalennau (o-i)670-681
Nifer y tudalennau12
CyfnodolynNature Reviews Microbiology
Cyfrol4
Rhif cyhoeddi9
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 01 Medi 2006

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