@article{c7c489707b374e33821817edf4e303de,
title = "Building confidence in quantitative systems pharmacology models: An engineer's guide to exploring the rationale in model design and development",
abstract = "This tutorial promotes good practice for exploring the rationale of systems pharmacology models. A safety systems engineering inspired notation approach provides much needed rigor and transparency in development and application of models for therapeutic discovery and design of intervention strategies. Structured arguments over a model's development, underpinning biological knowledge, and analyses of model behaviors are constructed to determine the confidence that a model is fit for the purpose for which it will be applied.",
keywords = "Animals, Antiprotozoal Agents/immunology, Biomedical Engineering/methods, Humans, Immunity, Cellular/drug effects, Leishmaniasis, Visceral/immunology, Models, Biological, Systems Biology/methods",
author = "J. Timmis and K. Alden and P. Andrews and E. Clark and A. Nellis and B. Naylor and M. Coles and P. Kaye",
note = "Funding Information: This work was partly funded by the Crack-IT Programme, grant number NC/C013117/1 and NC/C013205/1. P.M.K. would also like to acknowledge support from the MRC Programme grant G1000230. J.T. would like to acknowledge support from The Royal Academy of Engineering and The Royal Society. Publisher Copyright: {\textcopyright} 2016 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.",
year = "2017",
month = mar,
day = "1",
doi = "10.1002/psp4.12157",
language = "English",
volume = "6",
pages = "156--167",
journal = "CPT: Pharmacometrics and Systems Pharmacology",
issn = "2163-8306",
publisher = "Wiley",
number = "3",
}