Characterization of age-related changes in bovine CD8 + T-cells

Alison E. Hogg, Keith Parsons, Geraldine Taylor, Andrew Worth, Peter Beverley, Christopher J. Howard, Bernardo Villarreal-Ramos*

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

15 Dyfyniadau (Scopus)

Crynodeb

Evaluation of the changes induced by immunological interventions requires a baseline against which to compare those changes. The age-related changes in the CD8 + T-cell population of cattle were studied. The results indicate that CD8 + T-cells could be divided into γ/δ TCR1 + and γ/δ TCR1 - according to their expression of the γ/δ T-cell receptor. As a proportion, the CD8 + γ/δ TCR1 + population appears to increase with age. Within the CD8 +γ/δ TCR1 - a population of cells expressing a profile of surface molecules previously associated with effector memory T cells (CD45RO +, CD62L -, CD27 -, CD45RA - and CD28 -) increases with age. Furthermore, a parallel increase with age in the proportion of CD8 +CD45RO + T cells that express the cytotoxic granule protein perforin was observed. In peripheral tissues, namely lungs, it was found that the majority of CD8 + T cells present expressed a phenotype indicative of previously primed T cells (high expression of CD45RO and perforin). In contrast, only a small population of memory CD8 + T cells was present in lymphoid tissue where most of the CD8 + T cells expressed a naïve phenotype. In conclusion, in cattle, like in human, CD8 + T cells that express a phenotype associated with antigen experience accumulate with age that may play a role in immunocompetence as the individual ages.

Iaith wreiddiolSaesneg
Tudalennau (o-i)47-54
Nifer y tudalennau8
CyfnodolynVeterinary Immunology and Immunopathology
Cyfrol140
Rhif cyhoeddi1-2
Dyddiad ar-lein cynnar19 Tach 2010
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 15 Maw 2011

Ôl bys

Gweld gwybodaeth am bynciau ymchwil 'Characterization of age-related changes in bovine CD8 + T-cells'. Gyda’i gilydd, maen nhw’n ffurfio ôl bys unigryw.

Dyfynnu hyn