Classification of common functional loops of kinase super-families

Narcis Fernandez-Fuentes, Antoni Hermoso, Jordi Espadaler, Enrique Querol, Francesc X Aviles, Baldomero Oliva

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid


A structural classification of loops has been obtained from a set of 141 protein structures classified as kinases. A total of 1813 loops was classified into 133 subclasses (9 betabeta(links), 15 betabeta(hairpins), 31 alpha-alpha, 46 alpha-beta and 32 beta-alpha). Functional information and specific features relating subclasses and function were included in the classification. Functional loops such as the P-loop (shared by different folds) or the Gly-rich-loop, among others, were classified into structural motifs. As a result, a common mechanism of catalysis and substrate binding was proved for most kinases. Additionally, the multiple-alignment of loop sequences made within each subclass was shown to be useful for comparative modeling of kinase loops. The classification is summarized in a kinase loop database located at
Iaith wreiddiolSaesneg
Tudalennau (o-i)539-555
Nifer y tudalennau17
CyfnodolynProteins: Structure, Function and Genetics
Rhif cyhoeddi3
Dyddiad ar-lein cynnar16 Ebr 2004
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 15 Awst 2004

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