TY - JOUR
T1 - Complete genome sequence of the myxobacterium Sorangium cellulosum
AU - Schneiker, Susanne
AU - Perlova, Olena
AU - Kaiser, Olaf
AU - Gerth, Klaus
AU - Alici, Aysel
AU - Altmeyer, Matthias O
AU - Bartels, Daniela
AU - Bekel, Thomas
AU - Beyer, Stefan
AU - Bode, Edna
AU - Bode, Helge B
AU - Bolten, Christoph J
AU - Choudhuri, Jomuna V
AU - Doss, Sabrina
AU - Elnakady, Yasser A
AU - Frank, Bettina
AU - Gaigalat, Lars
AU - Goesmann, Alexander
AU - Groeger, Carolin
AU - Gross, Frank
AU - Jelsbak, Lars
AU - Jelsbak, Lotte
AU - Kalinowski, Jörn
AU - Kegler, Carsten
AU - Knauber, Tina
AU - Konietzny, Sebastian
AU - Kopp, Maren
AU - Krause, Lutz
AU - Krug, Daniel
AU - Linke, Bukhard
AU - Mahmud, Taifo
AU - Martinez-Arias, Rosa
AU - McHardy, Alice C
AU - Merai, Michelle
AU - Meyer, Folker
AU - Mormann, Sascha
AU - Muñoz-Dorado, Jose
AU - Perez, Juana
AU - Pradella, Silke
AU - Rachid, Shwan
AU - Raddatz, Günter
AU - Rosenau, Frank
AU - Rückert, Christian
AU - Sasse, Florenz
AU - Scharfe, Maren
AU - Schuster, Stephan C
AU - Suen, Garret
AU - Treuner-Lange, Anke
AU - Velicer, Gregory J
AU - Vorhölter, Frank-Jörg
AU - Weissman, Kira J
AU - Welch, Roy D
AU - Wenzel, Silke C
AU - Whitworth, David E
AU - Wilhelm, Susanne
AU - Wittmann, Christoph
AU - Blöcker, Helmut
AU - Pühler, Alfred
AU - Müller, Rolf
N1 - Schneiker, S., Perlova, O., Kaiser, O., Gerth, K., Alici, A., Altmeyer, M. O., Bartels, D., Bekel, T., Beyer, S., Bode, E., Bode, H. B., Bolten, C. J., Choudhuri, J. V., Doss, S., Elnakady, Y. A., Frank, B., Gaigalat, L., Goesmann, A., Groeger, C., Gross, F., Jelsbak, L., Jelsbak, L., Kalinowski, J., Kegler, C., Knauber, T., Konietzny, S., Kopp, M., Krause, L., Krug, D., Linke, B., Mahmud, T., Martinez-Arias, R., McHardy, A. C., Merai, M., Meyer, F., Mormann, S., Muñoz-Dorado, J., Perez, J., Pradella, S., Rachid, S., Raddatz, G., Rosenau, F., Rückert, C., Sasse, F., Scharfe, M., Schuster, S. C., Suen, G., Treuner-Lange, A., Velicer, G. J., Vorhölter, F-J., Weissman, K. J., Welch, R. D., Wenzel, S. C., Whitworth, D. E., Wilhelm, S., Wittmann, C., Blöcker, H., Pühler, A., Müller, R. (2007). Complete genome sequence of the myxobacterium Sorangium cellulosum. Nature Biotechnology, 25 (11), 1281-1289.
PY - 2007
Y1 - 2007
N2 - The genus Sorangium synthesizes approximately half of the secondary metabolites isolated from myxobacteria, including the anti-cancer metabolite epothilone. We report the complete genome sequence of the model Sorangium strain S. cellulosum So ce56, which produces several natural products and has morphological and physiological properties typical of the genus. The circular genome, comprising 13,033,779 base pairs, is the largest bacterial genome sequenced to date. No global synteny with the genome of Myxococcus xanthus is apparent, revealing an unanticipated level of divergence between these myxobacteria. A large percentage of the genome is devoted to regulation, particularly post-translational phosphorylation, which probably supports the strain's complex, social lifestyle. This regulatory network includes the highest number of eukaryotic protein kinase-like kinases discovered in any organism. Seventeen secondary metabolite loci are encoded in the genome, as well as many enzymes with potential utility in industry.
AB - The genus Sorangium synthesizes approximately half of the secondary metabolites isolated from myxobacteria, including the anti-cancer metabolite epothilone. We report the complete genome sequence of the model Sorangium strain S. cellulosum So ce56, which produces several natural products and has morphological and physiological properties typical of the genus. The circular genome, comprising 13,033,779 base pairs, is the largest bacterial genome sequenced to date. No global synteny with the genome of Myxococcus xanthus is apparent, revealing an unanticipated level of divergence between these myxobacteria. A large percentage of the genome is devoted to regulation, particularly post-translational phosphorylation, which probably supports the strain's complex, social lifestyle. This regulatory network includes the highest number of eukaryotic protein kinase-like kinases discovered in any organism. Seventeen secondary metabolite loci are encoded in the genome, as well as many enzymes with potential utility in industry.
UR - http://hdl.handle.net/2160/12864
U2 - 10.1038/nbt1354
DO - 10.1038/nbt1354
M3 - Article
C2 - 17965706
SN - 1087-0156
VL - 25
SP - 1281
EP - 1289
JO - Nature Biotechnology
JF - Nature Biotechnology
IS - 11
ER -
