Computational models of the NF-κB signalling pathway

Richard A. Williams*, Jon Timmis, Eva E. Qwarnstrom

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl Adolyguadolygiad gan gymheiriaid

48 Dyfyniadau(SciVal)


In this review article, we discuss the current state of computational modelling ofthe nuclear factor-kappa B (NF-κB) signalling pathway. NF-κB is a transcription factor, which is ubiquitous within cells and controls a number of immune responses, including inflammation and apoptosis. The NF-κB signalling pathway is tightly regulated, commencing with activation at the cell membrane, signal transduction through various components within the cytoplasm, translocation of NF-κB into the nucleus and, finally, the transcription of various genes relating to the innate and adaptive immune responses. There have been a number of computational (mathematical) models developed of the signalling pathway over the past decade. This review describes how these approaches have helped advance our understanding of NF-κB control.

Iaith wreiddiolSaesneg
Tudalennau (o-i)131-158
Nifer y tudalennau28
Rhif cyhoeddi4
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 2014
Cyhoeddwyd yn allanolIe

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