Detecting genetic regions associated with height in the native ponies of the British Isles by using high density SNP genotyping

I. Skujina; C. L. Winton; M. J. Hegarty; R. McMahon; D. M. Nash; M. C. G. Davies-Morel; N. R. McEwan

doi:10.1139/gen-2018-0006

Detecting genetic regions associated with height in the native ponies of the British Isles by using high density SNP genotyping

I. Skujina, C. L. Winton, M. J. Hegarty, R. McMahon, D. M. Nash, M. C. G. Davies-Morel, N. R. McEwan

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Height is an important characteristic in the equine industry although little is known about its genetic control in native British breeds of ponies. This study aimed to map QTL data with the withers height in four pony breeds native to the British Isles, including two different sections within Welsh Cobs. In this study, a genome-wide analysis approach using the Illumina EquineSNP50 Infinium BeadChip was applied to 105 ponies and cobs. Analysis identified 222 highly significant height-associated SNPs (P ≤ 10 ^-5), among which three SNPs on ECA9 have also been previously reported elsewhere. The highest number of significant SNPs associated to height in the native British horses were located on ECA1, ECA8, and ECA16.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	767-770
Nifer y tudalennau	4
Cyfnodolyn	Genome
Cyfrol	61
Rhif cyhoeddi	10
Dyddiad ar-lein cynnar	05 Medi 2018
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1139/gen-2018-0006
Statws	Cyhoeddwyd - Hyd 2018

Mynediad at Ddogfen

10.1139/gen-2018-0006Trwydded: CC BY-NC

Detecting genetic regions associated with height in the native ponies of the British Isles by using high density SNP genotypingLlawysgrif awdur wedi’i dderbyn, 462 KBTrwydded: CC BY-NC

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@article{48a565fc4cf04c7a974b1938b3d96d2b,

title = "Detecting genetic regions associated with height in the native ponies of the British Isles by using high density SNP genotyping",

abstract = "Height is an important characteristic in the equine industry although little is known about its genetic control in native British breeds of ponies. This study aimed to map QTL data with the withers height in four pony breeds native to the British Isles, including two different sections within Welsh Cobs. In this study, a genome-wide analysis approach using the Illumina EquineSNP50 Infinium BeadChip was applied to 105 ponies and cobs. Analysis identified 222 highly significant height-associated SNPs (P ≤ 10 -5), among which three SNPs on ECA9 have also been previously reported elsewhere. The highest number of significant SNPs associated to height in the native British horses were located on ECA1, ECA8, and ECA16.",

keywords = "Genome-wide association, Height, High density genotyping, Horse, Quantitative trait loci, Single nucleotide polymorphisms, Breeding, Chromosome Mapping, Biometry, Horses/anatomy & histology, Animals, High-Throughput Nucleotide Sequencing, Polymorphism, Single Nucleotide, Whole Genome Sequencing/methods, Genotyping Techniques/methods, Chromosomes, Mammalian/genetics, Quantitative Trait Loci",

author = "I. Skujina and Winton, {C. L.} and Hegarty, {M. J.} and R. McMahon and Nash, {D. M.} and Davies-Morel, {M. C. G.} and McEwan, {N. R.}",

note = "Publisher Copyright: {\textcopyright} 2018 Published by NRC Research Press.",

year = "2018",

month = oct,

doi = "10.1139/gen-2018-0006",

language = "English",

volume = "61",

pages = "767--770",

journal = "Genome",

issn = "0831-2796",

publisher = "National Research Council of Canada",

number = "10",

}

TY - JOUR

T1 - Detecting genetic regions associated with height in the native ponies of the British Isles by using high density SNP genotyping

AU - Skujina, I.

AU - Winton, C. L.

AU - Hegarty, M. J.

AU - McMahon, R.

AU - Nash, D. M.

AU - Davies-Morel, M. C. G.

AU - McEwan, N. R.

PY - 2018/10

Y1 - 2018/10

N2 - Height is an important characteristic in the equine industry although little is known about its genetic control in native British breeds of ponies. This study aimed to map QTL data with the withers height in four pony breeds native to the British Isles, including two different sections within Welsh Cobs. In this study, a genome-wide analysis approach using the Illumina EquineSNP50 Infinium BeadChip was applied to 105 ponies and cobs. Analysis identified 222 highly significant height-associated SNPs (P ≤ 10 -5), among which three SNPs on ECA9 have also been previously reported elsewhere. The highest number of significant SNPs associated to height in the native British horses were located on ECA1, ECA8, and ECA16.

AB - Height is an important characteristic in the equine industry although little is known about its genetic control in native British breeds of ponies. This study aimed to map QTL data with the withers height in four pony breeds native to the British Isles, including two different sections within Welsh Cobs. In this study, a genome-wide analysis approach using the Illumina EquineSNP50 Infinium BeadChip was applied to 105 ponies and cobs. Analysis identified 222 highly significant height-associated SNPs (P ≤ 10 -5), among which three SNPs on ECA9 have also been previously reported elsewhere. The highest number of significant SNPs associated to height in the native British horses were located on ECA1, ECA8, and ECA16.

KW - Genome-wide association

KW - Height

KW - High density genotyping

KW - Horse

KW - Quantitative trait loci

KW - Single nucleotide polymorphisms

KW - Breeding

KW - Chromosome Mapping

KW - Biometry

KW - Horses/anatomy & histology

KW - Animals

KW - High-Throughput Nucleotide Sequencing

KW - Polymorphism, Single Nucleotide

KW - Whole Genome Sequencing/methods

KW - Genotyping Techniques/methods

KW - Chromosomes, Mammalian/genetics

KW - Quantitative Trait Loci

UR - http://www.scopus.com/inward/record.url?scp=85054775045&partnerID=8YFLogxK

U2 - 10.1139/gen-2018-0006

DO - 10.1139/gen-2018-0006

M3 - Article

C2 - 30184439

SN - 0831-2796

VL - 61

SP - 767

EP - 770

JO - Genome

JF - Genome

IS - 10

ER -

Detecting genetic regions associated with height in the native ponies of the British Isles by using high density SNP genotyping

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