Distinct response kinetics of gamma interferon and interleukin-4 in bovine tuberculosis

S. G. Rhodes*, N. Palmer, S. P. Graham, A. E. Bianco, R. G. Hewinson, H. M. Vordermeier

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

54 Dyfyniadau (Scopus)

Crynodeb

This study shows that gamma interferon (IFN-γ) and interleukin-4 (IL-4) cytokine responses are produced by peripheral blood cells in cattle infected with Mycobacterium bovis. The different kinetics of the IFN-γ and IL-4 responses to bovine tuberculin and to ESAT-6 following experimental intratracheal infection with M. bovis are described. An early increase in IFN-γ was observed that was maintained throughout the period studied. In contrast, the IL-4 response was delayed and confined to a peak of activity lasting 6 to 8 weeks. Interestingly, an experimental challenge of cattle with a lower dose of M. bovis which did not result in the development of lesions, positive DTH skin test, or substantial IFN-γ responses nevertheless generated strong specific IL-4 responses. Investigation of naturally infected M. bovis field reactors showed increased IFN-γ and IL-4 responses compared to uninfected cattle and that both of these cytokines were equally able to differentiate infected from uninfected animals. The magnitude of the M. bovis-induced IL-4 responses were found to be similar to the antigen-specific IL-4 responses of cattle infected with the parasitic nematode Onchocerca ochengi, further supporting the presence of this type 2 cytokine in bovine tuberculosis.

Iaith wreiddiolSaesneg
Tudalennau (o-i)5393-5400
Nifer y tudalennau8
CyfnodolynInfection and Immunity
Cyfrol68
Rhif cyhoeddi9
Dyddiad ar-lein cynnar01 Medi 2000
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 14 Medi 2000

Ôl bys

Gweld gwybodaeth am bynciau ymchwil 'Distinct response kinetics of gamma interferon and interleukin-4 in bovine tuberculosis'. Gyda’i gilydd, maen nhw’n ffurfio ôl bys unigryw.

Dyfynnu hyn