Effect of scrapie incubation on the concentrations of plasma amino acids and L-lactate in infected lambs

G. G. Allison; P. Rees Stevens; L. Heasman; A. Davies; R. Jackman; J. M. Moorby

doi:10.1007/s11259-008-9067-5

Effect of scrapie incubation on the concentrations of plasma amino acids and L-lactate in infected lambs

G. G. Allison, P. Rees Stevens, L. Heasman, A. Davies, R. Jackman, J. M. Moorby

Gwyddorau Bywyd

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Crynodeb

Three groups of two weeks old growing lambs differing in PrP genotype were orally inoculated with scrapie and maintained under defined conditions until disease endpoint. Plasma concentrations of free alanine and serine, but not L-lactate increased during the final 6 months of the disease. At the same time, plasma concentrations of several essential and non-essential free amino acids decreased linearly, indicating reduced feed intake and are consistent with, but occurring before establishment, of cachexia. These observations are consistent with those reported previously from studies on cattle infected with BSE and with the hypothesis that scrapie may effect peripheral tissue metabolism.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	591-597
Nifer y tudalennau	7
Cyfnodolyn	Veterinary Research Communications
Cyfrol	32
Rhif cyhoeddi	8
Dyddiad ar-lein cynnar	12 Meh 2008
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1007/s11259-008-9067-5
Statws	Cyhoeddwyd - 01 Rhag 2008

Mynediad at Ddogfen

10.1007/s11259-008-9067-5

Cysylltiad parhaol

Dolen barhaus

Ffeiliau eraill a chysylltiadau

http://hdl.handle.net/2160/7973

1 Erthygl

Changes in plasma metabolites and muscle glycogen are correlated to bovine spongiform encephalopathy in infected dairy cattle
Allison, G., Horton, R. A., Rees Stevens, P., Jackman, R. & Moorby, J., Awst 2007, Yn: Research in Veterinary Science. 83, 1, t. 40-46 7 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Dyfynnu hyn

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title = "Effect of scrapie incubation on the concentrations of plasma amino acids and L-lactate in infected lambs",

abstract = "Three groups of two weeks old growing lambs differing in PrP genotype were orally inoculated with scrapie and maintained under defined conditions until disease endpoint. Plasma concentrations of free alanine and serine, but not L-lactate increased during the final 6 months of the disease. At the same time, plasma concentrations of several essential and non-essential free amino acids decreased linearly, indicating reduced feed intake and are consistent with, but occurring before establishment, of cachexia. These observations are consistent with those reported previously from studies on cattle infected with BSE and with the hypothesis that scrapie may effect peripheral tissue metabolism.",

keywords = "scrapie, lambs, plasma, amino acid, L-lactate, metabolism",

author = "Allison, {G. G.} and {Rees Stevens}, P. and L. Heasman and A. Davies and R. Jackman and Moorby, {J. M.}",

note = "IMPF: 00.63 RONO: 1930 4055 ",

year = "2008",

month = dec,

day = "1",

doi = "10.1007/s11259-008-9067-5",

language = "English",

volume = "32",

pages = "591--597",

journal = "Veterinary Research Communications",

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T1 - Effect of scrapie incubation on the concentrations of plasma amino acids and L-lactate in infected lambs

AU - Allison, G. G.

AU - Rees Stevens, P.

AU - Heasman, L.

AU - Davies, A.

AU - Jackman, R.

AU - Moorby, J. M.

N1 - IMPF: 00.63 RONO: 1930 4055

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Three groups of two weeks old growing lambs differing in PrP genotype were orally inoculated with scrapie and maintained under defined conditions until disease endpoint. Plasma concentrations of free alanine and serine, but not L-lactate increased during the final 6 months of the disease. At the same time, plasma concentrations of several essential and non-essential free amino acids decreased linearly, indicating reduced feed intake and are consistent with, but occurring before establishment, of cachexia. These observations are consistent with those reported previously from studies on cattle infected with BSE and with the hypothesis that scrapie may effect peripheral tissue metabolism.

AB - Three groups of two weeks old growing lambs differing in PrP genotype were orally inoculated with scrapie and maintained under defined conditions until disease endpoint. Plasma concentrations of free alanine and serine, but not L-lactate increased during the final 6 months of the disease. At the same time, plasma concentrations of several essential and non-essential free amino acids decreased linearly, indicating reduced feed intake and are consistent with, but occurring before establishment, of cachexia. These observations are consistent with those reported previously from studies on cattle infected with BSE and with the hypothesis that scrapie may effect peripheral tissue metabolism.

KW - scrapie

KW - lambs

KW - plasma

KW - amino acid

KW - L-lactate

KW - metabolism

UR - http://hdl.handle.net/2160/7973

U2 - 10.1007/s11259-008-9067-5

DO - 10.1007/s11259-008-9067-5

M3 - Article

C2 - 18548327

SN - 0165-7380

VL - 32

SP - 591

EP - 597

JO - Veterinary Research Communications

JF - Veterinary Research Communications

IS - 8

ER -

Effect of scrapie incubation on the concentrations of plasma amino acids and L-lactate in infected lambs

Crynodeb

Mynediad at Ddogfen

Cysylltiad parhaol

Ffeiliau eraill a chysylltiadau

Ôl bys

Allbwn Ymchwil

Changes in plasma metabolites and muscle glycogen are correlated to bovine spongiform encephalopathy in infected dairy cattle

Dyfynnu hyn