Enhanced resting-state functional connectivity between core memory-task activation peaks is associated with memory impairment in MCI

Yifei Zhang, Lee Simon-Vermot, Miguel Á. Araque Caballero, Benno Gesierich, Alexander N. W. Taylor, Marco Duering, Martin Dichgans, Michael Ewers

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

30 Dyfyniadau(SciVal)
303 Wedi eu Llwytho i Lawr (Pure)

Crynodeb

Resting-state functional connectivity (FC) is altered in Alzheimer's disease (AD) but its predictive value for episodic memory impairment is debated. Here, we aimed to assess whether resting-state FC in core brain regions activated during memory-task functional magnetic resonance imaging is altered and predictive of memory performance in AD and amnestic mild cognitive impairment (aMCI). Twenty-three elderly cognitively healthy controls (HC), 76 aMCI subjects, and 19 AD dementia patients were included. We computed resting-state FC between 18 meta-analytically determined peak coordinates of brain activation during successful memory retrieval. Higher FC between the parahippocampus, parietal cortex, and the middle frontal gyrus was observed in both AD and mild cognitive impairment compared to HC (false-discovery rate-corrected p < 0.05). The increase in FC between the parahippocampus and middle frontal gyrus was associated with reduced episodic memory in aMCI, independent of amyloid-beta positron emission tomography binding and apolipoprotein E ε4-carrier status. In conclusion, increased parahippocampal-prefrontal FC is predictive of impaired episodic memory in aMCI and may reflect a dysfunctional change within the episodic memory-related neural network.

Iaith wreiddiolSaesneg
Tudalennau (o-i)43-49
Nifer y tudalennau7
CyfnodolynNeurobiology of Aging
Cyfrol45
Dyddiad ar-lein cynnar03 Mai 2016
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 01 Medi 2016
Cyhoeddwyd yn allanolIe

Ôl bys

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