(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach

Celine Cosseau, Olaf Wolkenhauer, Gilda Padalino, Kathrin Geyer, Karl Hoffmann, Christoph Grunau

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl Adolyguadolygiad gan gymheiriaid

27 Dyfyniadau (Scopus)
209 Wedi eu Llwytho i Lawr (Pure)

Crynodeb

The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by ‘inheritance system’. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success.
Iaith wreiddiolSaesneg
Tudalennau (o-i)285-294
Nifer y tudalennau10
CyfnodolynTrends in Parasitology
Cyfrol33
Rhif cyhoeddi4
Dyddiad ar-lein cynnar28 Rhag 2016
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 01 Ebr 2017

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