Prosiectau fesul blwyddyn
Crynodeb
The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by ‘inheritance system’. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success.
Iaith wreiddiol | Saesneg |
---|---|
Tudalennau (o-i) | 285-294 |
Nifer y tudalennau | 10 |
Cyfnodolyn | Trends in Parasitology |
Cyfrol | 33 |
Rhif cyhoeddi | 4 |
Dyddiad ar-lein cynnar | 28 Rhag 2016 |
Dynodwyr Gwrthrych Digidol (DOIs) | |
Statws | Cyhoeddwyd - 01 Ebr 2017 |
Ôl bys
Gweld gwybodaeth am bynciau ymchwil '(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach'. Gyda’i gilydd, maen nhw’n ffurfio ôl bys unigryw.Prosiectau
- 1 Wedi Gorffen
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Flatworm DNA methylation: deciphering the mark and characterising the machinery
Hoffmann, K. (Prif Ymchwilydd)
Biotechnology and Biological Sciences Research Council
15 Ebr 2013 → 14 Ebr 2016
Prosiect: Ymchwil a ariannwyd yn allanol