Prosiectau fesul blwyddyn
The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by ‘inheritance system’. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success.
Ôl bysGweld gwybodaeth am bynciau ymchwil '(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach'. Gyda’i gilydd, maen nhw’n ffurfio ôl bys unigryw.
- 1 Wedi Gorffen
15 Ebr 2013 → 14 Ebr 2016
Prosiect: Ymchwil a ariannwyd yn allanol