Explanatory optimization of protein mass spectrometry via genetic search

Royston Goodacre; S. Vaidyanathan; David Iain Broadhurst; Douglas B. Kell

doi:10.1021/ac034669a

Explanatory optimization of protein mass spectrometry via genetic search

Royston Goodacre
, S. Vaidyanathan
, David Iain Broadhurst
, Douglas B. Kell

Athrofa'r Gwyddorau Biolegol, Amgylcheddol a Gwledig

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

40 Dyfyniadau (Scopus)

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Optimizing experimental conditions for the effective analysis of intact proteins by mass spectrometry is challenging, as many analytical factors influence the spectral quality, often in very different ways for different proteins and especially with complex protein mixtures. We show that genetic search methods are highly effective in this kind of optimization and that it was possible in 6 generations with a total of

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	6679-6686
Nifer y tudalennau	8
Cyfnodolyn	Analytical Chemistry
Cyfrol	75
Rhif cyhoeddi	3
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1021/ac034669a
Statws	Cyhoeddwyd - 25 Hyd 2003

Mynediad at Ddogfen

10.1021/ac034669a

http://hdl.handle.net/2160/4146

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title = "Explanatory optimization of protein mass spectrometry via genetic search",

abstract = "Optimizing experimental conditions for the effective analysis of intact proteins by mass spectrometry is challenging, as many analytical factors influence the spectral quality, often in very different ways for different proteins and especially with complex protein mixtures. We show that genetic search methods are highly effective in this kind of optimization and that it was possible in 6 generations with a total of ",

author = "Royston Goodacre and S. Vaidyanathan and Broadhurst, \{David Iain\} and Kell, \{Douglas B.\}",

note = "Vaidyanathan, S., Broadhurst, D. I., Kell, D. B., Goodacre, R. (2003). Explanatory optimization of protein mass spectrometry via genetic search. Analytical Chemistry, 75, (23), 6679-6686. Sponsorship: BBSRC/EPSRC",

year = "2003",

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doi = "10.1021/ac034669a",

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journal = "Analytical Chemistry",

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PY - 2003/10/25

Y1 - 2003/10/25

N2 - Optimizing experimental conditions for the effective analysis of intact proteins by mass spectrometry is challenging, as many analytical factors influence the spectral quality, often in very different ways for different proteins and especially with complex protein mixtures. We show that genetic search methods are highly effective in this kind of optimization and that it was possible in 6 generations with a total of

AB - Optimizing experimental conditions for the effective analysis of intact proteins by mass spectrometry is challenging, as many analytical factors influence the spectral quality, often in very different ways for different proteins and especially with complex protein mixtures. We show that genetic search methods are highly effective in this kind of optimization and that it was possible in 6 generations with a total of

U2 - 10.1021/ac034669a

DO - 10.1021/ac034669a

M3 - Article

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Explanatory optimization of protein mass spectrometry via genetic search

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