Genetic diversity among mycobacterium bovis isolates: A preliminary study of strains from animal and human sources

M. P.U. Sales; G. M. Taylor; S. Hughes; M. Yates; G. Hewinson; D. B. Young; R. J. Shaw

doi:10.1128/JCM.39.12.4558-4562.2001

Genetic diversity among mycobacterium bovis isolates: A preliminary study of strains from animal and human sources

M. P.U. Sales, G. M. Taylor^*, S. Hughes, M. Yates, G. Hewinson, D. B. Young, R. J. Shaw

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Mycobacterium bovis has the broadest host range of species in the Mycobacterium tuberculosis complex and is responsible for disease in humans and diverse animal species. We report on genotypic differences at multiple loci among 13 isolates derived from a range of human and animal infections. All isolates were classified as M. bovis by phenotypic analysis but could be subdivided into five distinct genotypes based on polymorphisms at the pncA and oxyR loci, the status of the RD5 deletion region, and the spoligotype pattern. These findings suggest the existence of a spectrum of strains with genotypic characteristics between those of M. tuberculosis and M. bovis.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	4558-4562
Nifer y tudalennau	5
Cyfnodolyn	Journal of Clinical Microbiology
Cyfrol	39
Rhif cyhoeddi	12
Dyddiad ar-lein cynnar	01 Rhag 2001
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1128/JCM.39.12.4558-4562.2001
Statws	Cyhoeddwyd - 17 Rhag 2001

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10.1128/JCM.39.12.4558-4562.2001

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@article{db2c0059732e4d06a0975803a2aeddb8,

title = "Genetic diversity among mycobacterium bovis isolates: A preliminary study of strains from animal and human sources",

abstract = "Mycobacterium bovis has the broadest host range of species in the Mycobacterium tuberculosis complex and is responsible for disease in humans and diverse animal species. We report on genotypic differences at multiple loci among 13 isolates derived from a range of human and animal infections. All isolates were classified as M. bovis by phenotypic analysis but could be subdivided into five distinct genotypes based on polymorphisms at the pncA and oxyR loci, the status of the RD5 deletion region, and the spoligotype pattern. These findings suggest the existence of a spectrum of strains with genotypic characteristics between those of M. tuberculosis and M. bovis.",

keywords = "Aged, Aged, 80 and over, Amidohydrolases/genetics, Animals, Bacterial Typing Techniques, Cats, Cattle, Female, Genetic Variation, Genotype, Humans, Male, Middle Aged, Mycobacterium bovis/classification, Oligonucleotides/analysis, Phenotype, Tuberculosis/microbiology",

author = "Sales, {M. P.U.} and Taylor, {G. M.} and S. Hughes and M. Yates and G. Hewinson and Young, {D. B.} and Shaw, {R. J.}",

year = "2001",

month = dec,

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doi = "10.1128/JCM.39.12.4558-4562.2001",

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T1 - Genetic diversity among mycobacterium bovis isolates

T2 - A preliminary study of strains from animal and human sources

AU - Sales, M. P.U.

AU - Taylor, G. M.

AU - Hughes, S.

AU - Yates, M.

AU - Hewinson, G.

AU - Young, D. B.

AU - Shaw, R. J.

PY - 2001/12/17

Y1 - 2001/12/17

N2 - Mycobacterium bovis has the broadest host range of species in the Mycobacterium tuberculosis complex and is responsible for disease in humans and diverse animal species. We report on genotypic differences at multiple loci among 13 isolates derived from a range of human and animal infections. All isolates were classified as M. bovis by phenotypic analysis but could be subdivided into five distinct genotypes based on polymorphisms at the pncA and oxyR loci, the status of the RD5 deletion region, and the spoligotype pattern. These findings suggest the existence of a spectrum of strains with genotypic characteristics between those of M. tuberculosis and M. bovis.

AB - Mycobacterium bovis has the broadest host range of species in the Mycobacterium tuberculosis complex and is responsible for disease in humans and diverse animal species. We report on genotypic differences at multiple loci among 13 isolates derived from a range of human and animal infections. All isolates were classified as M. bovis by phenotypic analysis but could be subdivided into five distinct genotypes based on polymorphisms at the pncA and oxyR loci, the status of the RD5 deletion region, and the spoligotype pattern. These findings suggest the existence of a spectrum of strains with genotypic characteristics between those of M. tuberculosis and M. bovis.

KW - Aged

KW - Aged, 80 and over

KW - Amidohydrolases/genetics

KW - Animals

KW - Bacterial Typing Techniques

KW - Cats

KW - Cattle

KW - Female

KW - Genetic Variation

KW - Genotype

KW - Humans

KW - Male

KW - Middle Aged

KW - Mycobacterium bovis/classification

KW - Oligonucleotides/analysis

KW - Phenotype

KW - Tuberculosis/microbiology

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U2 - 10.1128/JCM.39.12.4558-4562.2001

DO - 10.1128/JCM.39.12.4558-4562.2001

M3 - Article

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AN - SCOPUS:0035209467

SN - 0095-1137

VL - 39

SP - 4558

EP - 4562

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 12

ER -

Genetic diversity among mycobacterium bovis isolates: A preliminary study of strains from animal and human sources

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NDC y CU

Mynediad at Ddogfen

Cysylltiad parhaol

Ffeiliau eraill a chysylltiadau

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