How might flukes and tapeworms maintain genome integrity without a canonical piRNA pathway?

Danielle E. Skinner; Gabriel Rinaldi; Uriel Koziol; Klaus Brehm; Paul J. Brindley

doi:10.1016/j.pt.2014.01.001

How might flukes and tapeworms maintain genome integrity without a canonical piRNA pathway?

Danielle E. Skinner, Gabriel Rinaldi, Uriel Koziol, Klaus Brehm, Paul J. Brindley^*

^*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl olygyddol › adolygiad gan gymheiriaid

36 Dyfyniadau (Scopus)

Crynodeb

Surveillance by RNA interference is central to controlling the mobilization of transposable elements (TEs). In stem cells, Piwi argonaute (Ago) proteins and associated proteins repress mobilization of TEs to maintain genome integrity. This defense mechanism targeting TEs is termed the Piwi-interacting RNA (piRNA) pathway. In this opinion article, we draw attention to the situation that the genomes of cestodes and trematodes have lost the piwi and vasa genes that are hallmark characters of the germline multipotency program. This absence of Piwi-like Agos and Vasa helicases prompts the question: how does the germline of these flatworms withstand mobilization of TEs? Here, we present an interpretation of mechanisms likely to defend the germline integrity of parasitic flatworms.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	123-129
Nifer y tudalennau	7
Cyfnodolyn	Trends in Parasitology
Cyfrol	30
Rhif cyhoeddi	3
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1016/j.pt.2014.01.001
Statws	Cyhoeddwyd - Maw 2014
Cyhoeddwyd yn allanol	Ie

NDC y CU

Mae’r allbwn hwn yn cyfrannu at y Nod(au) Datblygu Cynaliadwy canlynol

Mynediad at Ddogfen

10.1016/j.pt.2014.01.001

Cysylltiad parhaol

Dolen barhaus

Ffeiliau eraill a chysylltiadau

Dolen i’r cyhoeddiad yn Scopus

Dyfynnu hyn

@article{946aab54b22e4a9580679bd7aa192418,

title = "How might flukes and tapeworms maintain genome integrity without a canonical piRNA pathway?",

abstract = "Surveillance by RNA interference is central to controlling the mobilization of transposable elements (TEs). In stem cells, Piwi argonaute (Ago) proteins and associated proteins repress mobilization of TEs to maintain genome integrity. This defense mechanism targeting TEs is termed the Piwi-interacting RNA (piRNA) pathway. In this opinion article, we draw attention to the situation that the genomes of cestodes and trematodes have lost the piwi and vasa genes that are hallmark characters of the germline multipotency program. This absence of Piwi-like Agos and Vasa helicases prompts the question: how does the germline of these flatworms withstand mobilization of TEs? Here, we present an interpretation of mechanisms likely to defend the germline integrity of parasitic flatworms.",

keywords = "Argonaute, Cestoda, Germline, PiRNA pathway, Piwi, Platyhelminthes, Transposable elements, Trematoda, Vasa, RNA, Small Interfering/genetics, Cestoda/genetics, DEAD-box RNA Helicases/genetics, Phylogeny, Argonaute Proteins/genetics, Genomic Instability/genetics, Animals, Trematoda/genetics, Protein Processing, Post-Translational",

author = "Skinner, {Danielle E.} and Gabriel Rinaldi and Uriel Koziol and Klaus Brehm and Brindley, {Paul J.}",

note = "Funding Information: We thank Dr Matty Knight for insightful comments on the manuscript. Support for doctoral studies (DES) from the Institute of Biomedical Sciences of The George Washington University is gratefully acknowledged. These studies were supported by National Institutes of Health–National Institute of Allergy and Infectious Diseases (NIH–NIAID) award R01AI072773. ",

year = "2014",

month = mar,

doi = "10.1016/j.pt.2014.01.001",

language = "English",

volume = "30",

pages = "123--129",

journal = "Trends in Parasitology",

issn = "1471-4922",