Iminosugar Amino Acid idoBR1 Reduces Inflammatory Responses in Microglia

OA Olajide; VU Iwuanyanwu; OW Banjo; A Kato; YB Penkova; GWJ Fleet; RJ Nash

doi:10.3390/molecules27103342

Iminosugar Amino Acid idoBR1 Reduces Inflammatory Responses in Microglia

OA Olajide
, VU Iwuanyanwu
, OW Banjo
, A Kato
, YB Penkova
, GWJ Fleet
, RJ Nash^*

^*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

5 Dyfyniadau (Scopus)

56 Wedi eu Llwytho i Lawr (Pure)

Crynodeb

Background
Inflammation is reported to be a key factor in neurodegeneration. The microglia are immune cells present in the central nervous system; their activation results in the release of inflammatory cytokines and is thought to be related to aging and neurodegenerative disorders, such as Alzheimer’s disease.

Methods
A mouse BV-2 microglia cell line was activated using LPS and the anti-inflammatory cucumber-derived iminosugar amino acid idoBR1, (2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid, was used alongside dexamethasone as the control to determine whether it could reduce the inflammatory responses.

Results
A dose-dependent reduction in the LPS-induced production of the proinflammatory factors TNFα, IL-6, and nitric oxide and the transcription factor NF-κB was found.

Conclusions
Further investigations of the anti-inflammatory effects of idoBR1 in other models of neurodegenerative diseases are warranted.

Iaith wreiddiol	Saesneg
Rhif yr erthygl	3342
Nifer y tudalennau	11
Cyfnodolyn	Molecules
Cyfrol	27
Rhif cyhoeddi	10
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.3390/molecules27103342
Statws	Cyhoeddwyd - 23 Mai 2022
Cyhoeddwyd yn allanol	Ie

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ArticleFersiwn derfynol wedi’i chyhoeddi, 681 KBTrwydded: CC BY

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@article{d7357625ffa446c58c22b4fef39e7cca,

title = "Iminosugar Amino Acid idoBR1 Reduces Inflammatory Responses in Microglia",

abstract = "Background Inflammation is reported to be a key factor in neurodegeneration. The microglia are immune cells present in the central nervous system; their activation results in the release of inflammatory cytokines and is thought to be related to aging and neurodegenerative disorders, such as Alzheimer{\textquoteright}s disease. Methods A mouse BV-2 microglia cell line was activated using LPS and the anti-inflammatory cucumber-derived iminosugar amino acid idoBR1, (2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid, was used alongside dexamethasone as the control to determine whether it could reduce the inflammatory responses. Results A dose-dependent reduction in the LPS-induced production of the proinflammatory factors TNFα, IL-6, and nitric oxide and the transcription factor NF-κB was found. Conclusions Further investigations of the anti-inflammatory effects of idoBR1 in other models of neurodegenerative diseases are warranted.",

keywords = "(2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid, Cucumis sativus, iminosugar amino acid-idoBR1, lipopolysaccharide, microglia cell line, neuroprotection, pro-inflammatory factors",

author = "OA Olajide and VU Iwuanyanwu and OW Banjo and A Kato and YB Penkova and GWJ Fleet and RJ Nash",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = may,

day = "23",

doi = "10.3390/molecules27103342",

language = "English",

volume = "27",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute",

number = "10",

}

TY - JOUR

T1 - Iminosugar Amino Acid idoBR1 Reduces Inflammatory Responses in Microglia

AU - Olajide, OA

AU - Iwuanyanwu, VU

AU - Banjo, OW

AU - Kato, A

AU - Penkova, YB

AU - Fleet, GWJ

AU - Nash, RJ

PY - 2022/5/23

Y1 - 2022/5/23

N2 - Background Inflammation is reported to be a key factor in neurodegeneration. The microglia are immune cells present in the central nervous system; their activation results in the release of inflammatory cytokines and is thought to be related to aging and neurodegenerative disorders, such as Alzheimer’s disease. Methods A mouse BV-2 microglia cell line was activated using LPS and the anti-inflammatory cucumber-derived iminosugar amino acid idoBR1, (2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid, was used alongside dexamethasone as the control to determine whether it could reduce the inflammatory responses. Results A dose-dependent reduction in the LPS-induced production of the proinflammatory factors TNFα, IL-6, and nitric oxide and the transcription factor NF-κB was found. Conclusions Further investigations of the anti-inflammatory effects of idoBR1 in other models of neurodegenerative diseases are warranted.

AB - Background Inflammation is reported to be a key factor in neurodegeneration. The microglia are immune cells present in the central nervous system; their activation results in the release of inflammatory cytokines and is thought to be related to aging and neurodegenerative disorders, such as Alzheimer’s disease. Methods A mouse BV-2 microglia cell line was activated using LPS and the anti-inflammatory cucumber-derived iminosugar amino acid idoBR1, (2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid, was used alongside dexamethasone as the control to determine whether it could reduce the inflammatory responses. Results A dose-dependent reduction in the LPS-induced production of the proinflammatory factors TNFα, IL-6, and nitric oxide and the transcription factor NF-κB was found. Conclusions Further investigations of the anti-inflammatory effects of idoBR1 in other models of neurodegenerative diseases are warranted.

KW - (2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid

KW - Cucumis sativus

KW - iminosugar amino acid-idoBR1

KW - lipopolysaccharide

KW - microglia cell line

KW - neuroprotection

KW - pro-inflammatory factors

UR - https://www.scopus.com/pages/publications/85130553852

U2 - 10.3390/molecules27103342

DO - 10.3390/molecules27103342

M3 - Article

C2 - 35630818

SN - 1420-3049

VL - 27

JO - Molecules

JF - Molecules

IS - 10

M1 - 3342

ER -

Iminosugar Amino Acid idoBR1 Reduces Inflammatory Responses in Microglia

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