Iminosugars from Baphia mitida Lodd

Atsushi Kato; Noriko Kato; Saori Miyauchi; Yuka Minoshima; Isao Adachi; Kyoko Ikeda; Naoki Asano; Alison A. Watson; Robert J. Nash

doi:10.1016/j.phytochem.2007.11.018

Iminosugars from Baphia mitida Lodd

Atsushi Kato, Noriko Kato, Saori Miyauchi, Yuka Minoshima, Isao Adachi, Kyoko Ikeda, Naoki Asano, Alison A. Watson, Robert J. Nash

Adran y Gwyddorau Bywyd

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

35 Dyfyniadau (Scopus)

Crynodeb

Chromatographic separation of the 50% aqueous EtOH extract of the leaves of the African medicinal tree Baphia nitida resulted in isolation of 10 iminosugars. The plant contained 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine (DMDP) as a major alkaloid. The structure of a new alkaloid was also elucidated by spectroscopic methods as the 1-O-β-d-fructofuranoside of DMDP, and this plant produced 3-O-β-d-glucopyranosyl-DMDP as well. DMDP is a potent inhibitor of β-glucosidase and β-galactosidase, whereas the other two derivatives lowered inhibition toward both of these enzymes and improved inhibitory activities toward rice α-glucosidase and rat intestinal maltase.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	1261-1265
Nifer y tudalennau	5
Cyfnodolyn	Phytochemistry
Cyfrol	69
Rhif cyhoeddi	5
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1016/j.phytochem.2007.11.018
Statws	Cyhoeddwyd - Maw 2008

Mynediad at Ddogfen

10.1016/j.phytochem.2007.11.018

http://hdl.handle.net/2160/2337

Cysylltiad parhaol

Dolen barhaus

Dyfynnu hyn

@article{3139a0bc972a468b879d7005c143c81e,

title = "Iminosugars from Baphia mitida Lodd",

abstract = "Chromatographic separation of the 50% aqueous EtOH extract of the leaves of the African medicinal tree Baphia nitida resulted in isolation of 10 iminosugars. The plant contained 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine (DMDP) as a major alkaloid. The structure of a new alkaloid was also elucidated by spectroscopic methods as the 1-O-β-d-fructofuranoside of DMDP, and this plant produced 3-O-β-d-glucopyranosyl-DMDP as well. DMDP is a potent inhibitor of β-glucosidase and β-galactosidase, whereas the other two derivatives lowered inhibition toward both of these enzymes and improved inhibitory activities toward rice α-glucosidase and rat intestinal maltase.",

author = "Atsushi Kato and Noriko Kato and Saori Miyauchi and Yuka Minoshima and Isao Adachi and Kyoko Ikeda and Naoki Asano and Watson, {Alison A.} and Nash, {Robert J.}",

note = "Kato, A., Kato, N., Miyauchi, S., Minoshima, Y., Adachi, I., Ikeda, K., Asano, N., Watson, A. A., Nash, R. J. (2008). Iminosugars from Baphia mitida Lodd. Phytochemistry, 69, 1261-1265. Sponsorship: Ministry of Education, Culture, Sports, Science and Technology, Grant-in-Aid for Young Scientists, 18790086 and Cooperative Research Center of Life Science . On file IMPF: 02.95 RONO: 00 ",

year = "2008",

month = mar,

doi = "10.1016/j.phytochem.2007.11.018",

language = "English",

volume = "69",

pages = "1261--1265",

journal = "Phytochemistry",

issn = "1873-3700",

publisher = "Elsevier",

number = "5",

}

TY - JOUR

T1 - Iminosugars from Baphia mitida Lodd

AU - Kato, Atsushi

AU - Kato, Noriko

AU - Miyauchi, Saori

AU - Minoshima, Yuka

AU - Adachi, Isao

AU - Ikeda, Kyoko

AU - Asano, Naoki

AU - Watson, Alison A.

AU - Nash, Robert J.

N1 - Kato, A., Kato, N., Miyauchi, S., Minoshima, Y., Adachi, I., Ikeda, K., Asano, N., Watson, A. A., Nash, R. J. (2008). Iminosugars from Baphia mitida Lodd. Phytochemistry, 69, 1261-1265. Sponsorship: Ministry of Education, Culture, Sports, Science and Technology, Grant-in-Aid for Young Scientists, 18790086 and Cooperative Research Center of Life Science . On file IMPF: 02.95 RONO: 00

PY - 2008/3

Y1 - 2008/3

N2 - Chromatographic separation of the 50% aqueous EtOH extract of the leaves of the African medicinal tree Baphia nitida resulted in isolation of 10 iminosugars. The plant contained 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine (DMDP) as a major alkaloid. The structure of a new alkaloid was also elucidated by spectroscopic methods as the 1-O-β-d-fructofuranoside of DMDP, and this plant produced 3-O-β-d-glucopyranosyl-DMDP as well. DMDP is a potent inhibitor of β-glucosidase and β-galactosidase, whereas the other two derivatives lowered inhibition toward both of these enzymes and improved inhibitory activities toward rice α-glucosidase and rat intestinal maltase.

AB - Chromatographic separation of the 50% aqueous EtOH extract of the leaves of the African medicinal tree Baphia nitida resulted in isolation of 10 iminosugars. The plant contained 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine (DMDP) as a major alkaloid. The structure of a new alkaloid was also elucidated by spectroscopic methods as the 1-O-β-d-fructofuranoside of DMDP, and this plant produced 3-O-β-d-glucopyranosyl-DMDP as well. DMDP is a potent inhibitor of β-glucosidase and β-galactosidase, whereas the other two derivatives lowered inhibition toward both of these enzymes and improved inhibitory activities toward rice α-glucosidase and rat intestinal maltase.

U2 - 10.1016/j.phytochem.2007.11.018

DO - 10.1016/j.phytochem.2007.11.018

M3 - Article

C2 - 18191969

SN - 1873-3700

VL - 69

SP - 1261

EP - 1265

JO - Phytochemistry

JF - Phytochemistry

IS - 5

ER -

Iminosugars from Baphia mitida Lodd

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Mynediad at Ddogfen

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