Immune reactions of CD4- and CD8-positive T cell subpopulations in spleen and lymph nodes of guinea pigs after vaccination with Bacillus Calmette Guerin

Thomas Klünner; Thomas Bartels; Martin Vordermeier; Reinhard Burger; Hubert Schäfer

doi:10.1016/S0264-410X(00)00429-1

Immune reactions of CD4- and CD8-positive T cell subpopulations in spleen and lymph nodes of guinea pigs after vaccination with Bacillus Calmette Guerin

Thomas Klünner, Thomas Bartels, Martin Vordermeier, Reinhard Burger, Hubert Schäfer^*

^*Awdur cyfatebol y gwaith hwn

TB buchol, clefydau a rheolaeth

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

17 Dyfyniadau (Scopus)

Crynodeb

Vaccination of guinea pigs with Mycobacterium bovis BCG confers partial resistance against infection with Mycobacterium tuberculosis. Induction of immunity is associated with a strong T cell response. The reactions of the cytotoxic and helper T lymphocyte subsets after BCG vaccination were analyzed by cytofluorometry and in functional tests. The relative number of CD8⁺ T cells in the spleen increased substantially after injection of BCG. In vitro restimulation after immunization induced a strong proliferative response but no cytotoxic reactions of CD8⁺ T cells against BCG-infected macrophages. A specific induction of IFN-γ and RANTES mRNA was observed after vaccination particularly in CD8⁺ but not in CD4⁺ T cells of the lymph nodes.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	1968-1977
Nifer y tudalennau	10
Cyfnodolyn	Vaccine
Cyfrol	19
Rhif cyhoeddi	15-16
Dyddiad ar-lein cynnar	22 Chwef 2001
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1016/S0264-410X(00)00429-1
Statws	Cyhoeddwyd - 28 Chwef 2001

NDC y CU

Mae’r allbwn hwn yn cyfrannu at y Nod(au) Datblygu Cynaliadwy canlynol

Mynediad at Ddogfen

10.1016/S0264-410X(00)00429-1

Cysylltiad parhaol

Dolen barhaus

Ffeiliau eraill a chysylltiadau

Link to publication in Scopus

Dyfynnu hyn

@article{52bafb01380041fd96856bf94ce9c008,

title = "Immune reactions of CD4- and CD8-positive T cell subpopulations in spleen and lymph nodes of guinea pigs after vaccination with Bacillus Calmette Guerin",

abstract = "Vaccination of guinea pigs with Mycobacterium bovis BCG confers partial resistance against infection with Mycobacterium tuberculosis. Induction of immunity is associated with a strong T cell response. The reactions of the cytotoxic and helper T lymphocyte subsets after BCG vaccination were analyzed by cytofluorometry and in functional tests. The relative number of CD8+ T cells in the spleen increased substantially after injection of BCG. In vitro restimulation after immunization induced a strong proliferative response but no cytotoxic reactions of CD8+ T cells against BCG-infected macrophages. A specific induction of IFN-γ and RANTES mRNA was observed after vaccination particularly in CD8+ but not in CD4+ T cells of the lymph nodes.",

keywords = "Guinea pig, Mycobacteria, T lymphocytes",

author = "Thomas Kl{\"u}nner and Thomas Bartels and Martin Vordermeier and Reinhard Burger and Hubert Sch{\"a}fer",

year = "2001",

month = feb,

day = "28",

doi = "10.1016/S0264-410X(00)00429-1",

language = "English",

volume = "19",

pages = "1968--1977",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier",

number = "15-16",

}

TY - JOUR

T1 - Immune reactions of CD4- and CD8-positive T cell subpopulations in spleen and lymph nodes of guinea pigs after vaccination with Bacillus Calmette Guerin

AU - Klünner, Thomas

AU - Bartels, Thomas

AU - Vordermeier, Martin

AU - Burger, Reinhard

AU - Schäfer, Hubert

PY - 2001/2/28

Y1 - 2001/2/28

N2 - Vaccination of guinea pigs with Mycobacterium bovis BCG confers partial resistance against infection with Mycobacterium tuberculosis. Induction of immunity is associated with a strong T cell response. The reactions of the cytotoxic and helper T lymphocyte subsets after BCG vaccination were analyzed by cytofluorometry and in functional tests. The relative number of CD8+ T cells in the spleen increased substantially after injection of BCG. In vitro restimulation after immunization induced a strong proliferative response but no cytotoxic reactions of CD8+ T cells against BCG-infected macrophages. A specific induction of IFN-γ and RANTES mRNA was observed after vaccination particularly in CD8+ but not in CD4+ T cells of the lymph nodes.

AB - Vaccination of guinea pigs with Mycobacterium bovis BCG confers partial resistance against infection with Mycobacterium tuberculosis. Induction of immunity is associated with a strong T cell response. The reactions of the cytotoxic and helper T lymphocyte subsets after BCG vaccination were analyzed by cytofluorometry and in functional tests. The relative number of CD8+ T cells in the spleen increased substantially after injection of BCG. In vitro restimulation after immunization induced a strong proliferative response but no cytotoxic reactions of CD8+ T cells against BCG-infected macrophages. A specific induction of IFN-γ and RANTES mRNA was observed after vaccination particularly in CD8+ but not in CD4+ T cells of the lymph nodes.

KW - Guinea pig

KW - Mycobacteria

KW - T lymphocytes

UR - http://www.scopus.com/inward/record.url?scp=0035961551&partnerID=8YFLogxK

U2 - 10.1016/S0264-410X(00)00429-1

DO - 10.1016/S0264-410X(00)00429-1

M3 - Article

C2 - 11228367

AN - SCOPUS:0035961551

SN - 0264-410X

VL - 19

SP - 1968

EP - 1977

JO - Vaccine

JF - Vaccine

IS - 15-16

ER -

Immune reactions of CD4- and CD8-positive T cell subpopulations in spleen and lymph nodes of guinea pigs after vaccination with Bacillus Calmette Guerin

Crynodeb

NDC y CU

Mynediad at Ddogfen

Cysylltiad parhaol

Ffeiliau eraill a chysylltiadau

Ôl bys

Dyfynnu hyn