Immune responses induced in cattle by vaccination with a recombinant adenovirus expressing mycobacterial antigen 85A and Mycobacterium bovis BCG

H. Martin Vordermeier; Kris Huygen; Mahavir Singh; R. Glyn Hewinson; Zhou Xing

doi:10.1128/IAI.74.2.1416-1418.2006

Immune responses induced in cattle by vaccination with a recombinant adenovirus expressing mycobacterial antigen 85A and Mycobacterium bovis BCG

H. Martin Vordermeier^*, Kris Huygen, Mahavir Singh, R. Glyn Hewinson, Zhou Xing

^*Awdur cyfatebol y gwaith hwn

TB buchol, clefydau a rheolaeth

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Crynodeb

Cattle were vaccinated with an adenovirus expressing the mycobacterial antigen 85A (rAd85A), with Mycobacterium bovis BCG followed by rAd85A heterologous boosting, or with rAd85A followed by BCG boosting. BCG/rAd85A resulted in the highest direct gamma Interferon responses. Cultured enzyme-linked immunospot assay analysis demonstrated that memory responses were induced by all three protocols but were strongest after BCG/rAd85A and rAd85A/BCG vaccination.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	1416-1418
Nifer y tudalennau	3
Cyfnodolyn	Infection and Immunity
Cyfrol	74
Rhif cyhoeddi	2
Dyddiad ar-lein cynnar	20 Ion 2006
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1128/IAI.74.2.1416-1418.2006
Statws	Cyhoeddwyd - 01 Chwef 2006

NDC y CU

Mae’r allbwn hwn yn cyfrannu at y Nod(au) Datblygu Cynaliadwy canlynol

Mynediad at Ddogfen

10.1128/IAI.74.2.1416-1418.2006

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Link to publication in Scopus

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@article{537f5167d3694a1794bfa1651eb9b6f9,

title = "Immune responses induced in cattle by vaccination with a recombinant adenovirus expressing mycobacterial antigen 85A and Mycobacterium bovis BCG",

abstract = "Cattle were vaccinated with an adenovirus expressing the mycobacterial antigen 85A (rAd85A), with Mycobacterium bovis BCG followed by rAd85A heterologous boosting, or with rAd85A followed by BCG boosting. BCG/rAd85A resulted in the highest direct gamma Interferon responses. Cultured enzyme-linked immunospot assay analysis demonstrated that memory responses were induced by all three protocols but were strongest after BCG/rAd85A and rAd85A/BCG vaccination.",

author = "Vordermeier, {H. Martin} and Kris Huygen and Mahavir Singh and Hewinson, {R. Glyn} and Zhou Xing",

year = "2006",

month = feb,

day = "1",

doi = "10.1128/IAI.74.2.1416-1418.2006",

language = "English",

volume = "74",

pages = "1416--1418",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

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TY - JOUR

T1 - Immune responses induced in cattle by vaccination with a recombinant adenovirus expressing mycobacterial antigen 85A and Mycobacterium bovis BCG

AU - Vordermeier, H. Martin

AU - Huygen, Kris

AU - Singh, Mahavir

AU - Hewinson, R. Glyn

AU - Xing, Zhou

PY - 2006/2/1

Y1 - 2006/2/1

N2 - Cattle were vaccinated with an adenovirus expressing the mycobacterial antigen 85A (rAd85A), with Mycobacterium bovis BCG followed by rAd85A heterologous boosting, or with rAd85A followed by BCG boosting. BCG/rAd85A resulted in the highest direct gamma Interferon responses. Cultured enzyme-linked immunospot assay analysis demonstrated that memory responses were induced by all three protocols but were strongest after BCG/rAd85A and rAd85A/BCG vaccination.

AB - Cattle were vaccinated with an adenovirus expressing the mycobacterial antigen 85A (rAd85A), with Mycobacterium bovis BCG followed by rAd85A heterologous boosting, or with rAd85A followed by BCG boosting. BCG/rAd85A resulted in the highest direct gamma Interferon responses. Cultured enzyme-linked immunospot assay analysis demonstrated that memory responses were induced by all three protocols but were strongest after BCG/rAd85A and rAd85A/BCG vaccination.

UR - http://www.scopus.com/inward/record.url?scp=31844433211&partnerID=8YFLogxK

U2 - 10.1128/IAI.74.2.1416-1418.2006

DO - 10.1128/IAI.74.2.1416-1418.2006

M3 - Article

C2 - 16428796

AN - SCOPUS:31844433211

SN - 0019-9567

VL - 74

SP - 1416

EP - 1418

JO - Infection and Immunity

JF - Infection and Immunity

IS - 2

ER -

Immune responses induced in cattle by vaccination with a recombinant adenovirus expressing mycobacterial antigen 85A and Mycobacterium bovis BCG

Crynodeb

NDC y CU

Mynediad at Ddogfen

Cysylltiad parhaol

Ffeiliau eraill a chysylltiadau

Ôl bys

Dyfynnu hyn