Immunopathology of schistosomiasis mansoni in mice and men

A W Cheever, K F Hoffmann, T A Wynn

Allbwn ymchwil: Cyfraniad at gyfnodolynLlythyradolygiad gan gymheiriaid

87 Dyfyniadau(SciVal)

Crynodeb

Padraic Fallon recently presented an excellent summary of cytokine responses and immunopathology in infected mice and humans1. We wish to take issue with several points, including Fallon’s implication that morbidity and death in immunodeficient mice caused by type 1 cytokine responses is relevant to human schistosomiasis. In this model, hepatocellular toxicity1 and 2 is apparently caused by Schistosoma mansoni egg antigens that are neutralized in immunologically intact mice 2 and 3. Fallon et al. recently presented a detailed description of this response2. In considering the varied causes of morbidity and mortality in humans and mice (Table 1) this toxicity, termed ‘cytokine shock’ in the table, has no apparent counterpart in infected humans.
Iaith wreiddiolSaesneg
Tudalennau (o-i)465-466
Nifer y tudalennau2
CyfnodolynImmunology Today
Cyfrol21
Rhif cyhoeddi9
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 01 Medi 2000

Ôl bys

Gweld gwybodaeth am bynciau ymchwil 'Immunopathology of schistosomiasis mansoni in mice and men'. Gyda’i gilydd, maen nhw’n ffurfio ôl bys unigryw.

Dyfynnu hyn