In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis

Richard A. Williams; Mark Read; Jon Timmis; Paul S. Andrews; Vipin Kumar

doi:10.1007/978-3-642-22371-6_5

In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis

Richard A. Williams^*, Mark Read, Jon Timmis, Paul S. Andrews, Vipin Kumar

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Experimental autoimmune encephalomyelitis (EAE) is an animal model of human autoimmune diseases in general, and multiple sclerosis (MS) in particular [2]. The animal disease is mediated through a network of cells; encephalitogenic CDThelper (CD4Th1) cells are activated in the peripheral lymph nodes following immunization for EAE, and migrate to the central nervous system where they induce activation of microglia, macrophages and dendritic cells (DCs). The resultant inflammation causes demyelination of neurons, prompting the presentation of myelin basic protein (MBP) to additional encephalitogenic T cell populations in the cervical lymph nodes by migratory DCs. The spontaneous recovery that occurs following autoimmune episodes is associated with the induction of apoptosis in encephalitogenic CD4Th1 cells by a CD8 regulatory T cell (CD8Treg) population [1,6]. Tang et al [7] demonstrated a mechanism where CD4Treg cells assist DCs in priming CD8Treg cells, which mediate down-regulation of the autoimmune response through selective apoptotic elimination of CD4Th1 cells.

Iaith wreiddiol	Saesneg
Teitl	Artificial Immune Systems - 10th International Conference, ICARIS 2011, Proceedings
Cyhoeddwr	Springer Nature
Tudalennau	51-54
Nifer y tudalennau	4
ISBN (Argraffiad)	9783642223709
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1007/978-3-642-22371-6_5
Statws	Cyhoeddwyd - 2011
Cyhoeddwyd yn allanol	Ie
Digwyddiad	10th International Conference on Artificial Immune Systems, ICARIS 2011 - Cambridge, Teyrnas Unedig Prydain Fawr a Gogledd Iwerddon Hyd: 18 Gorff 2011 → 21 Gorff 2011

Cyfres gyhoeddiadau

Enw	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Cyfrol	6825 LNCS
ISSN (Argraffiad)	0302-9743
ISSN (Electronig)	1611-3349

Cynhadledd

Cynhadledd	10th International Conference on Artificial Immune Systems, ICARIS 2011
Gwlad/Tiriogaeth	Teyrnas Unedig Prydain Fawr a Gogledd Iwerddon
Dinas	Cambridge
Cyfnod	18 Gorff 2011 → 21 Gorff 2011

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10.1007/978-3-642-22371-6_5

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Williams, R. A., Read, M., Timmis, J., Andrews, P. S., & Kumar, V. (2011). In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis. Yn Artificial Immune Systems - 10th International Conference, ICARIS 2011, Proceedings (tt. 51-54). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Cyfrol 6825 LNCS). Springer Nature. https://doi.org/10.1007/978-3-642-22371-6_5

Williams, Richard A. ; Read, Mark ; Timmis, Jon et al. / In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis. Artificial Immune Systems - 10th International Conference, ICARIS 2011, Proceedings. Springer Nature, 2011. tt. 51-54 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

@inproceedings{b30ae9bea6614cc8859551c00763bb3d,

title = "In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis",

abstract = "Experimental autoimmune encephalomyelitis (EAE) is an animal model of human autoimmune diseases in general, and multiple sclerosis (MS) in particular [2]. The animal disease is mediated through a network of cells; encephalitogenic CDThelper (CD4Th1) cells are activated in the peripheral lymph nodes following immunization for EAE, and migrate to the central nervous system where they induce activation of microglia, macrophages and dendritic cells (DCs). The resultant inflammation causes demyelination of neurons, prompting the presentation of myelin basic protein (MBP) to additional encephalitogenic T cell populations in the cervical lymph nodes by migratory DCs. The spontaneous recovery that occurs following autoimmune episodes is associated with the induction of apoptosis in encephalitogenic CD4Th1 cells by a CD8 regulatory T cell (CD8Treg) population [1,6]. Tang et al [7] demonstrated a mechanism where CD4Treg cells assist DCs in priming CD8Treg cells, which mediate down-regulation of the autoimmune response through selective apoptotic elimination of CD4Th1 cells.",

author = "Williams, {Richard A.} and Mark Read and Jon Timmis and Andrews, {Paul S.} and Vipin Kumar",

year = "2011",

doi = "10.1007/978-3-642-22371-6_5",

language = "English",

isbn = "9783642223709",

series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",

publisher = "Springer Nature",

pages = "51--54",

booktitle = "Artificial Immune Systems - 10th International Conference, ICARIS 2011, Proceedings",

address = "Switzerland",

note = "10th International Conference on Artificial Immune Systems, ICARIS 2011 ; Conference date: 18-07-2011 Through 21-07-2011",

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Williams, RA, Read, M, Timmis, J, Andrews, PS & Kumar, V 2011, In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis. yn Artificial Immune Systems - 10th International Conference, ICARIS 2011, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), cyfrol. 6825 LNCS, Springer Nature, tt. 51-54, 10th International Conference on Artificial Immune Systems, ICARIS 2011, Cambridge, Teyrnas Unedig Prydain Fawr a Gogledd Iwerddon, 18 Gorff 2011. https://doi.org/10.1007/978-3-642-22371-6_5

In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis. / Williams, Richard A.; Read, Mark; Timmis, Jon et al.
Artificial Immune Systems - 10th International Conference, ICARIS 2011, Proceedings. Springer Nature, 2011. t. 51-54 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Cyfrol 6825 LNCS).

Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Trafodion Cynhadledd (Nid-Cyfnodolyn fathau)

TY - GEN

T1 - In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis

AU - Williams, Richard A.

AU - Read, Mark

AU - Timmis, Jon

AU - Andrews, Paul S.

AU - Kumar, Vipin

PY - 2011

Y1 - 2011

N2 - Experimental autoimmune encephalomyelitis (EAE) is an animal model of human autoimmune diseases in general, and multiple sclerosis (MS) in particular [2]. The animal disease is mediated through a network of cells; encephalitogenic CDThelper (CD4Th1) cells are activated in the peripheral lymph nodes following immunization for EAE, and migrate to the central nervous system where they induce activation of microglia, macrophages and dendritic cells (DCs). The resultant inflammation causes demyelination of neurons, prompting the presentation of myelin basic protein (MBP) to additional encephalitogenic T cell populations in the cervical lymph nodes by migratory DCs. The spontaneous recovery that occurs following autoimmune episodes is associated with the induction of apoptosis in encephalitogenic CD4Th1 cells by a CD8 regulatory T cell (CD8Treg) population [1,6]. Tang et al [7] demonstrated a mechanism where CD4Treg cells assist DCs in priming CD8Treg cells, which mediate down-regulation of the autoimmune response through selective apoptotic elimination of CD4Th1 cells.

AB - Experimental autoimmune encephalomyelitis (EAE) is an animal model of human autoimmune diseases in general, and multiple sclerosis (MS) in particular [2]. The animal disease is mediated through a network of cells; encephalitogenic CDThelper (CD4Th1) cells are activated in the peripheral lymph nodes following immunization for EAE, and migrate to the central nervous system where they induce activation of microglia, macrophages and dendritic cells (DCs). The resultant inflammation causes demyelination of neurons, prompting the presentation of myelin basic protein (MBP) to additional encephalitogenic T cell populations in the cervical lymph nodes by migratory DCs. The spontaneous recovery that occurs following autoimmune episodes is associated with the induction of apoptosis in encephalitogenic CD4Th1 cells by a CD8 regulatory T cell (CD8Treg) population [1,6]. Tang et al [7] demonstrated a mechanism where CD4Treg cells assist DCs in priming CD8Treg cells, which mediate down-regulation of the autoimmune response through selective apoptotic elimination of CD4Th1 cells.

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SN - 9783642223709

T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

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Williams RA, Read M, Timmis J, Andrews PS, Kumar V. In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis. Yn Artificial Immune Systems - 10th International Conference, ICARIS 2011, Proceedings. Springer Nature. 2011. t. 51-54. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/978-3-642-22371-6_5

In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis

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