In silico investigation into CD8Treg mediated recovery in murine experimental autoimmune encephalomyelitis

Richard A. Williams*, Mark Read, Jon Timmis, Paul S. Andrews, Vipin Kumar

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion CynhadleddTrafodion Cynhadledd (Nid-Cyfnodolyn fathau)

1 Dyfyniadau(SciVal)

Crynodeb

Experimental autoimmune encephalomyelitis (EAE) is an animal model of human autoimmune diseases in general, and multiple sclerosis (MS) in particular [2]. The animal disease is mediated through a network of cells; encephalitogenic CDThelper (CD4Th1) cells are activated in the peripheral lymph nodes following immunization for EAE, and migrate to the central nervous system where they induce activation of microglia, macrophages and dendritic cells (DCs). The resultant inflammation causes demyelination of neurons, prompting the presentation of myelin basic protein (MBP) to additional encephalitogenic T cell populations in the cervical lymph nodes by migratory DCs. The spontaneous recovery that occurs following autoimmune episodes is associated with the induction of apoptosis in encephalitogenic CD4Th1 cells by a CD8 regulatory T cell (CD8Treg) population [1,6]. Tang et al [7] demonstrated a mechanism where CD4Treg cells assist DCs in priming CD8Treg cells, which mediate down-regulation of the autoimmune response through selective apoptotic elimination of CD4Th1 cells.

Iaith wreiddiolSaesneg
TeitlArtificial Immune Systems - 10th International Conference, ICARIS 2011, Proceedings
CyhoeddwrSpringer Nature
Tudalennau51-54
Nifer y tudalennau4
ISBN (Argraffiad)9783642223709
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 2011
Cyhoeddwyd yn allanolIe
Digwyddiad10th International Conference on Artificial Immune Systems, ICARIS 2011 - Cambridge, Teyrnas Unedig Prydain Fawr a Gogledd Iwerddon
Hyd: 18 Gorff 201121 Gorff 2011

Cyfres gyhoeddiadau

EnwLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Cyfrol6825 LNCS
ISSN (Argraffiad)0302-9743
ISSN (Electronig)1611-3349

Cynhadledd

Cynhadledd10th International Conference on Artificial Immune Systems, ICARIS 2011
Gwlad/TiriogaethTeyrnas Unedig Prydain Fawr a Gogledd Iwerddon
DinasCambridge
Cyfnod18 Gorff 201121 Gorff 2011

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