In vitro screening as an anthelmintic discovery pipeline for Calicophoron daubneyi: Nutritive media and rumen environment-based approaches

Kathryn Mair Huson, Russ Morphew, Ana Winters, Alan Cookson, Barbara Hauck, Peter Brophy

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

1 Dyfyniadau(SciVal)
99 Wedi eu Llwytho i Lawr (Pure)

Crynodeb

Paramphistomosis can lead to morbidity and mortality of ruminant livestock within tropical and sub-tropical climates. In recent decades, rumen fluke has become an emerging infection in temperate climates across Western Europe, with Calicophoron daubneyi, the primary species present. Clinical outbreaks with C. daubneyi larvae are reported and adults might be responsible for production losses. There is not currently a widely licensed anthelmintic product available to control C. daubneyi. In this study, three existing flukicide anthelmintics were tested for efficacy against mature C. daubneyi, comparing a standard in vitro culturing assay and a new more relevant rumen fluid based in vitro compound screening protocol. The new rumen based screen confirmed that oxyclozanide was active against adult C. daubneyi and identified activity with praziquantel. The study highlighted the downstream value of incorporating relevant in vitro screening for anthelmintic discovery pipelines.
Iaith wreiddiolSaesneg
Tudalennau (o-i)1351-1362
Nifer y tudalennau12
CyfnodolynParasitology Research
Cyfrol120
Rhif cyhoeddi4
Dyddiad ar-lein cynnar06 Chwef 2021
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 01 Ebr 2021

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