Integrating transcriptome, proteome and glycome analyses of Schistosoma biology

Cornelis H Hokke, Jennifer M Fitzpatrick, Karl F Hoffmann

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

66 Dyfyniadau(SciVal)

Crynodeb

Publication of the transcriptomes of Schistosoma mansoni and Schistosoma japonicum, in conjunction with the sequencing and assembly of their genomes, has generated a comprehensive picture of Schistosoma transcriptional and genomic diversity. Subsequently, researchers who study conjugal and developmental biology, tegumental composition and larval or egg, secretory and excretory products have used these data, in combination with the latest '-omics' technologies, to extend large-scale screens of the schistosome transcriptome, proteome and glycome. In this article, we review these postgenomic investigations and contend that the generated datasets provide a plethora of novel drug, vaccine and immunomodulatory targets that might be useful for developing new antischistosome agents.
Iaith wreiddiolSaesneg
Tudalennau (o-i)165-174
Nifer y tudalennau10
CyfnodolynTrends in Parasitology
Cyfrol23
Rhif cyhoeddi4
Dyddiad ar-lein cynnar01 Maw 2007
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - Ebr 2007

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