Intranasal BCG vaccination protects BALB/c mice against virulent Mycobacterium bovis and accelerates production of IFN-γ in their lungs

I. V. Lyadova; H. M. Vordermeier; E. B. Eruslanov; S. V. Khaidukov; A. S. Apt; R. G. Hewinson

doi:10.1046/j.1365-2249.2001.01667.x

Intranasal BCG vaccination protects BALB/c mice against virulent Mycobacterium bovis and accelerates production of IFN-γ in their lungs

I. V. Lyadova^*, H. M. Vordermeier, E. B. Eruslanov, S. V. Khaidukov, A. S. Apt, R. G. Hewinson

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Local immune reactivity in the lungs of BALB/c mice was studied following (i) intranasal (i.n.) vaccination with Mycobacterium bovis BCG, (ii) intravenous (i.v.) challenge with a virulent M. bovis field isolate and (iii) i.n. vaccination with M. bovis BCG followed by i.v. challenge with an M. bovis field isolate. The results demonstrated that i.n. vaccination with BCG induced a high degree of protection against systemic M. bovis challenge, and that this protection correlated with a rapid production of IFN-γ after M. bovis challenge by lung T cells from vaccinated mice.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	274-279
Nifer y tudalennau	6
Cyfnodolyn	Clinical and Experimental Immunology
Cyfrol	126
Rhif cyhoeddi	2
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1046/j.1365-2249.2001.01667.x
Statws	Cyhoeddwyd - 06 Tach 2001

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10.1046/j.1365-2249.2001.01667.x

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@article{c3b1e1bd1be4473787dcafbcca5201ec,

title = "Intranasal BCG vaccination protects BALB/c mice against virulent Mycobacterium bovis and accelerates production of IFN-γ in their lungs",

abstract = "Local immune reactivity in the lungs of BALB/c mice was studied following (i) intranasal (i.n.) vaccination with Mycobacterium bovis BCG, (ii) intravenous (i.v.) challenge with a virulent M. bovis field isolate and (iii) i.n. vaccination with M. bovis BCG followed by i.v. challenge with an M. bovis field isolate. The results demonstrated that i.n. vaccination with BCG induced a high degree of protection against systemic M. bovis challenge, and that this protection correlated with a rapid production of IFN-γ after M. bovis challenge by lung T cells from vaccinated mice.",

keywords = "Immunity in the lung, Intranasal vaccination, M. bovis infection",

author = "Lyadova, {I. V.} and Vordermeier, {H. M.} and Eruslanov, {E. B.} and Khaidukov, {S. V.} and Apt, {A. S.} and Hewinson, {R. G.}",

year = "2001",

month = nov,

day = "6",

doi = "10.1046/j.1365-2249.2001.01667.x",

language = "English",

volume = "126",

pages = "274--279",

journal = "Clinical and Experimental Immunology",

issn = "0009-9104",

publisher = "Oxford University Press",

number = "2",

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TY - JOUR

T1 - Intranasal BCG vaccination protects BALB/c mice against virulent Mycobacterium bovis and accelerates production of IFN-γ in their lungs

AU - Lyadova, I. V.

AU - Vordermeier, H. M.

AU - Eruslanov, E. B.

AU - Khaidukov, S. V.

AU - Apt, A. S.

AU - Hewinson, R. G.

PY - 2001/11/6

Y1 - 2001/11/6

N2 - Local immune reactivity in the lungs of BALB/c mice was studied following (i) intranasal (i.n.) vaccination with Mycobacterium bovis BCG, (ii) intravenous (i.v.) challenge with a virulent M. bovis field isolate and (iii) i.n. vaccination with M. bovis BCG followed by i.v. challenge with an M. bovis field isolate. The results demonstrated that i.n. vaccination with BCG induced a high degree of protection against systemic M. bovis challenge, and that this protection correlated with a rapid production of IFN-γ after M. bovis challenge by lung T cells from vaccinated mice.

AB - Local immune reactivity in the lungs of BALB/c mice was studied following (i) intranasal (i.n.) vaccination with Mycobacterium bovis BCG, (ii) intravenous (i.v.) challenge with a virulent M. bovis field isolate and (iii) i.n. vaccination with M. bovis BCG followed by i.v. challenge with an M. bovis field isolate. The results demonstrated that i.n. vaccination with BCG induced a high degree of protection against systemic M. bovis challenge, and that this protection correlated with a rapid production of IFN-γ after M. bovis challenge by lung T cells from vaccinated mice.

KW - Immunity in the lung

KW - Intranasal vaccination

KW - M. bovis infection

UR - http://www.scopus.com/inward/record.url?scp=0034782438&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2249.2001.01667.x

DO - 10.1046/j.1365-2249.2001.01667.x

M3 - Article

C2 - 11703371

AN - SCOPUS:0034782438

SN - 0009-9104

VL - 126

SP - 274

EP - 279

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

IS - 2

ER -

Intranasal BCG vaccination protects BALB/c mice against virulent Mycobacterium bovis and accelerates production of IFN-γ in their lungs

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