Looking glass inhibitors: L-DMDP, a more potent and specific inhibitor of alpha-glucosidases than the enantiomeric natural product DMDP

Robert J. Nash, Naoki Asano, Ana L. Winters, C. Y. Yu, George W. J. Fleet, T. D. Butters, Kyoko Ikeda, R. A. Dwek, M. R. Wormald, M. X. Wang

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

68 Dyfyniadau(SciVal)

Crynodeb

L-DMDP, prepared from D-gulonolactone, is a highly specific inhibitor of a number of plant and mammalian -glucosidases [between 2 and 4 orders of magnitude more potent than the enantiomeric natural product DMDP] but is not an inhibitor of bacterial and yeast -glucosidases. Additionally N-butyl-DMDP is a potent inhibitor of ceramide-specific glucosyltransferase but N-butyl-L-DMDP shows no inhibition.
Iaith wreiddiolSaesneg
Tudalennau (o-i)1936-1937
Nifer y tudalennau2
CyfnodolynChemical Communications
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 29 Gorff 2004

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