Methodologies for quantitative systems pharmacology (QSP) models: Design and estimation

B. Ribba; H. P. Grimm; B. Agoram; M. R. Davies; K. Gadkar; S. Niederer; N. Van Riel; J. Timmis; P. H. Van Der Graaf

doi:10.1002/psp4.12206

Methodologies for quantitative systems pharmacology (QSP) models: Design and estimation

B. Ribba^*, H. P. Grimm, B. Agoram, M. R. Davies, K. Gadkar, S. Niederer, N. Van Riel, J. Timmis, P. H. Van Der Graaf

^*Awdur cyfatebol y gwaith hwn

Cyfrifiadureg

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl Adolygu › adolygiad gan gymheiriaid

29 Dyfyniadau (Scopus)

Crynodeb

With the increased interest in the application of quantitative systems pharmacology (QSP) models within medicine research and development, there is an increasing need to formalize model development and verification aspects. In February 2016, a workshop was held at Roche Pharma Research and Early Development to focus discussions on two critical methodological aspects of QSP model development: optimal structural granularity and parameter estimation. We here report in a perspective article a summary of presentations and discussions.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	496-498
Nifer y tudalennau	3
Cyfnodolyn	CPT: Pharmacometrics and Systems Pharmacology
Cyfrol	6
Rhif cyhoeddi	8
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1002/psp4.12206
Statws	Cyhoeddwyd - Awst 2017

Mynediad at Ddogfen

10.1002/psp4.12206

Cysylltiad parhaol

Dolen barhaus

Ffeiliau eraill a chysylltiadau

Dolen i’r cyhoeddiad yn Scopus

Dyfynnu hyn

@article{5f8509d265dc4e5aaa9b567c048d641d,

title = "Methodologies for quantitative systems pharmacology (QSP) models: Design and estimation",

abstract = "With the increased interest in the application of quantitative systems pharmacology (QSP) models within medicine research and development, there is an increasing need to formalize model development and verification aspects. In February 2016, a workshop was held at Roche Pharma Research and Early Development to focus discussions on two critical methodological aspects of QSP model development: optimal structural granularity and parameter estimation. We here report in a perspective article a summary of presentations and discussions.",

keywords = "Congresses as Topic, Drug Design, Drug Discovery/methods, Humans, Systems Biology/methods",

author = "B. Ribba and Grimm, {H. P.} and B. Agoram and Davies, {M. R.} and K. Gadkar and S. Niederer and {Van Riel}, N. and J. Timmis and {Van Der Graaf}, {P. H.}",

note = "{\textcopyright} 2017 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.",

year = "2017",

month = aug,

doi = "10.1002/psp4.12206",

language = "English",

volume = "6",

pages = "496--498",

journal = "CPT: Pharmacometrics and Systems Pharmacology",

issn = "2163-8306",

publisher = "Wiley",

number = "8",

}

TY - JOUR

T1 - Methodologies for quantitative systems pharmacology (QSP) models

T2 - Design and estimation

AU - Ribba, B.

AU - Grimm, H. P.

AU - Agoram, B.

AU - Davies, M. R.

AU - Gadkar, K.

AU - Niederer, S.

AU - Van Riel, N.

AU - Timmis, J.

AU - Van Der Graaf, P. H.

PY - 2017/8

Y1 - 2017/8

N2 - With the increased interest in the application of quantitative systems pharmacology (QSP) models within medicine research and development, there is an increasing need to formalize model development and verification aspects. In February 2016, a workshop was held at Roche Pharma Research and Early Development to focus discussions on two critical methodological aspects of QSP model development: optimal structural granularity and parameter estimation. We here report in a perspective article a summary of presentations and discussions.

AB - With the increased interest in the application of quantitative systems pharmacology (QSP) models within medicine research and development, there is an increasing need to formalize model development and verification aspects. In February 2016, a workshop was held at Roche Pharma Research and Early Development to focus discussions on two critical methodological aspects of QSP model development: optimal structural granularity and parameter estimation. We here report in a perspective article a summary of presentations and discussions.

KW - Congresses as Topic

KW - Drug Design

KW - Drug Discovery/methods

KW - Humans

KW - Systems Biology/methods

UR - http://www.scopus.com/inward/record.url?scp=85023166594&partnerID=8YFLogxK

U2 - 10.1002/psp4.12206

DO - 10.1002/psp4.12206

M3 - Review Article

C2 - 28585415

AN - SCOPUS:85023166594

SN - 2163-8306

VL - 6

SP - 496

EP - 498

JO - CPT: Pharmacometrics and Systems Pharmacology

JF - CPT: Pharmacometrics and Systems Pharmacology

IS - 8

ER -

Methodologies for quantitative systems pharmacology (QSP) models: Design and estimation

Crynodeb

Mynediad at Ddogfen

Cysylltiad parhaol

Ffeiliau eraill a chysylltiadau

Ôl bys

Dyfynnu hyn