Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected cattle

Martin Vordermeier; Stephen V. Gordon; R. Glyn Hewinson

doi:10.1016/j.vetmic.2011.02.020

Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected cattle

Martin Vordermeier^*, Stephen V. Gordon, R. Glyn Hewinson

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Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

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The urgency for new and improved cattle vaccines and diagnostic reagents for Bovine tuberculosis (TB) has made their development a research priority in Great Britain (GB). Significant progress has been made to develop specific antigens that allow the differentiation of BCG vaccinated and Mycobacterium bovis infected cattle (DIVA test). This has been greatly facilitated by the completion of the genome sequences of M. tuberculosis, M. bovis and BCG Pasteur and the subsequent application of comparative genome and transcriptome analysis to define DIVA antigens that complemented the prototype DIVA antigens ESAT-6 and CFP-10 by increasing their test sensitivity. Finally, we present an up-date of our current approaches in this area.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	8-13
Nifer y tudalennau	6
Cyfnodolyn	Veterinary Microbiology
Cyfrol	151
Rhif cyhoeddi	1-2
Dyddiad ar-lein cynnar	24 Chwef 2011
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1016/j.vetmic.2011.02.020
Statws	Cyhoeddwyd - 05 Gorff 2011

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Mae’r allbwn hwn yn cyfrannu at y Nod(au) Datblygu Cynaliadwy canlynol

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10.1016/j.vetmic.2011.02.020

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title = "Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected cattle",

abstract = "The urgency for new and improved cattle vaccines and diagnostic reagents for Bovine tuberculosis (TB) has made their development a research priority in Great Britain (GB). Significant progress has been made to develop specific antigens that allow the differentiation of BCG vaccinated and Mycobacterium bovis infected cattle (DIVA test). This has been greatly facilitated by the completion of the genome sequences of M. tuberculosis, M. bovis and BCG Pasteur and the subsequent application of comparative genome and transcriptome analysis to define DIVA antigens that complemented the prototype DIVA antigens ESAT-6 and CFP-10 by increasing their test sensitivity. Finally, we present an up-date of our current approaches in this area.",

keywords = "Antigen reagents, BCG, Differential diagnosis, DIVA, Mycobacterium bovis, Mycobacterium tuberculosis",

author = "Martin Vordermeier and Gordon, {Stephen V.} and Hewinson, {R. Glyn}",

year = "2011",

month = jul,

day = "5",

doi = "10.1016/j.vetmic.2011.02.020",

language = "English",

volume = "151",

pages = "8--13",

journal = "Veterinary Microbiology",

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T1 - Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected cattle

AU - Vordermeier, Martin

AU - Gordon, Stephen V.

AU - Hewinson, R. Glyn

PY - 2011/7/5

Y1 - 2011/7/5

N2 - The urgency for new and improved cattle vaccines and diagnostic reagents for Bovine tuberculosis (TB) has made their development a research priority in Great Britain (GB). Significant progress has been made to develop specific antigens that allow the differentiation of BCG vaccinated and Mycobacterium bovis infected cattle (DIVA test). This has been greatly facilitated by the completion of the genome sequences of M. tuberculosis, M. bovis and BCG Pasteur and the subsequent application of comparative genome and transcriptome analysis to define DIVA antigens that complemented the prototype DIVA antigens ESAT-6 and CFP-10 by increasing their test sensitivity. Finally, we present an up-date of our current approaches in this area.

AB - The urgency for new and improved cattle vaccines and diagnostic reagents for Bovine tuberculosis (TB) has made their development a research priority in Great Britain (GB). Significant progress has been made to develop specific antigens that allow the differentiation of BCG vaccinated and Mycobacterium bovis infected cattle (DIVA test). This has been greatly facilitated by the completion of the genome sequences of M. tuberculosis, M. bovis and BCG Pasteur and the subsequent application of comparative genome and transcriptome analysis to define DIVA antigens that complemented the prototype DIVA antigens ESAT-6 and CFP-10 by increasing their test sensitivity. Finally, we present an up-date of our current approaches in this area.

KW - Antigen reagents

KW - BCG

KW - Differential diagnosis

KW - DIVA

KW - Mycobacterium bovis

KW - Mycobacterium tuberculosis

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DO - 10.1016/j.vetmic.2011.02.020

M3 - Article

C2 - 21411245

AN - SCOPUS:79957459642

SN - 0378-1135

VL - 151

SP - 8

EP - 13

JO - Veterinary Microbiology

JF - Veterinary Microbiology

IS - 1-2

ER -

Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected cattle

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