N- and O-Alkylation of isoquinolin-1-ones in the Mitsunobu reaction: Development of potential drug delivery systems

Sandra Ferrer, Declan P. Naughton, Ifat Parveen, Michael D. Threadgill

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

32 Dyfyniadau(SciVal)
135 Wedi eu Llwytho i Lawr (Pure)

Crynodeb

Regioselective methods were investigated to prepare N- and O-alkylated isoquinolin-1-ones efficiently. The predicted regioselective alkylation of the nitrogen with (hetero)benzyl halides was complemented using (hetero)benzylic Mitsunobu electrophiles to alkylate predominantly at the oxygen. A series of drug-delivery conjugates was prepared demonstrating control over the site of alkylation. The Mitsunobu reaction provides a new approach to 1-alkoxyisoquinolines that were unavailable via previous harsher synthetic methods.
Iaith wreiddiolSaesneg
Tudalennau (o-i)335-340
Nifer y tudalennau6
CyfnodolynJournal of the Chemical Society, Perkin Transactions 1
Cyfrol2
Rhif cyhoeddi3
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 24 Ion 2002
Cyhoeddwyd yn allanolIe

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