Novel approaches to the visualization and quantification of biological simulations by emulating experimental techniques

James A. Butler*, Kieran Alden, Henrique Veiga Fernandes, Jon Timmis, Mark Coles

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion CynhadleddTrafodion Cynhadledd (Nid-Cyfnodolyn fathau)

4 Dyfyniadau(SciVal)

Crynodeb

The use of modeling and simulation as a predictive tool for research in biology is becoming increasingly popular. However, outputs from such simulations are often abstract and presented in a very different manner to equivalent data from the biological domain. Therefore, we have developed a flexible tool-chain for emulating various biological laboratory techniques to produce biologically homomorphic outputs in computer simulations. This includes virtual immunohistochemistry, microscopy, flow cytometry, and gene expression heatmaps. We present a case study in the use of this tool-chain applied to a simulation of pre-natal lymphoid organ development. We find that application of the tool-chain provides additional, biologically relevant data, that is inaccessible with pre-existing methodologies for analysis of simulation results. We argue that biological experimental techniques borrowed from the wet-lab are an important additional approach to the analysis of simulations in computational biology, and might furthermore inspire confidence in simulation results from the perspective of experimental biologists.

Iaith wreiddiolSaesneg
TeitlArtificial Life 14 - Proceedings of the 14th International Conference on the Synthesis and Simulation of Living Systems, ALIFE 2014
GolygyddionHiroki Sayama, John Rieffel, Sebastian Risi, Rene Doursat, Hod Lipson
CyhoeddwrMIT Press Journals
Tudalennau614-621
Nifer y tudalennau8
ISBN (Electronig)9780262326216
StatwsCyhoeddwyd - 2014
Digwyddiad14th International Conference on the Synthesis and Simulation of Living Systems, ALIFE 2014 - Manhattan, Unol Daleithiau America
Hyd: 30 Gorff 201402 Awst 2014

Cyfres gyhoeddiadau

EnwArtificial Life 14 - Proceedings of the 14th International Conference on the Synthesis and Simulation of Living Systems, ALIFE 2014

Cynhadledd

Cynhadledd14th International Conference on the Synthesis and Simulation of Living Systems, ALIFE 2014
Gwlad/TiriogaethUnol Daleithiau America
DinasManhattan
Cyfnod30 Gorff 201402 Awst 2014

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