Oral vaccination of cattle with heat inactivated Mycobacterium bovis does not compromise bovine TB diagnostic tests

Gareth J. Jones*, Sabine Steinbach, Iker A. Sevilla, Joseba M. Garrido, Ramon Juste, H. Martin Vordermeier

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

20 Dyfyniadau(SciVal)
79 Wedi eu Llwytho i Lawr (Pure)

Crynodeb

In this study we investigated whether oral uptake of a heat inactivated M. bovis wildlife vaccine by domestic cattle induced systemic immune responses that compromised the use of tuberculin or defined antigens in diagnostic tests for bovine TB. Positive skin test and blood-based IFN-γ release assay (IGRA) results were observed in all calves vaccinated via the parenteral route (i.e. intramuscular). In contrast, no positive responses to tuberculin or defined antigens were observed in either the skin test or IGRA test when performed in calves vaccinated via the oral route. In conclusion, our results suggest that the heat inactivated M. bovis vaccine could be used to vaccinate wildlife in a baited form in conjunction with the following in cattle: (i) continuation of existing tuberculin skin testing or novel skin test formats based on defined antigens; and (ii) the use of IGRA tests utilizing tuberculin or defined antigens.

Iaith wreiddiolSaesneg
Tudalennau (o-i)85-88
Nifer y tudalennau4
CyfnodolynVeterinary Immunology and Immunopathology
Cyfrol182
Dyddiad ar-lein cynnar19 Hyd 2016
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 01 Rhag 2016

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