Polyhydroxylated alkaloids - natural occurrence and therapeutic applications

Naoki Asano; George W. J. Fleet; Alison A. Watson; Russell J. Molyneux; Robert J. Nash

doi:10.1016/S0031-9422(00)00451-9

Polyhydroxylated alkaloids - natural occurrence and therapeutic applications

Naoki Asano
, George W. J. Fleet
, Alison A. Watson
, Russell J. Molyneux
, Robert J. Nash

Athrofa'r Gwyddorau Biolegol, Amgylcheddol a Gwledig

Hokuriku University
University of Oxford
Chubb (Switzerland)
United States Department of Agriculture
Institute of Environmental Science and Research

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

760 Dyfyniadau (Scopus)

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Over one hundred polyhydroxylated alkaloids have been isolated from plants and micro-organisms. These alkaloids can be potent and highly selective glycosidase inhibitors and are arousing great interest as tools to study cellular recognition and as potential therapeutic agents. However, only three of the natural products so far have been widely studied for therapeutic potential due largely to the limited commercial availability of the other compounds.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	265-295
Nifer y tudalennau	31
Cyfnodolyn	Phytochemistry
Cyfrol	56
Rhif cyhoeddi	3
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1016/S0031-9422(00)00451-9
Statws	Cyhoeddwyd - 21 Chwef 2001

Mynediad at Ddogfen

10.1016/S0031-9422(00)00451-9

http://hdl.handle.net/2160/3519

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@article{6c78990598224ff688bae68e1053c713,

title = "Polyhydroxylated alkaloids - natural occurrence and therapeutic applications",

abstract = "Over one hundred polyhydroxylated alkaloids have been isolated from plants and micro-organisms. These alkaloids can be potent and highly selective glycosidase inhibitors and are arousing great interest as tools to study cellular recognition and as potential therapeutic agents. However, only three of the natural products so far have been widely studied for therapeutic potential due largely to the limited commercial availability of the other compounds.",

keywords = "Glycosidase, Indolizidines, Inhibitors, N-Containing sugars, Nortropanes, Piperidines, Pyrrolidines, Pyrrolizidines",

author = "Naoki Asano and Fleet, \{George W. J.\} and Watson, \{Alison A.\} and Molyneux, \{Russell J.\} and Nash, \{Robert J.\}",

note = "Watson, A. A., Fleet, G. W. J., Asano, N., Molyneux, R. J., Nash, R. J. (2001). Polyhydroxylated alkaloids - natural occurrence and therapeutic applications. Phytochemistry, 56, 265-295",

year = "2001",

month = feb,

day = "21",

doi = "10.1016/S0031-9422(00)00451-9",

language = "English",

volume = "56",

pages = "265--295",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Polyhydroxylated alkaloids - natural occurrence and therapeutic applications

AU - Asano, Naoki

AU - Fleet, George W. J.

AU - Watson, Alison A.

AU - Molyneux, Russell J.

AU - Nash, Robert J.

N1 - Watson, A. A., Fleet, G. W. J., Asano, N., Molyneux, R. J., Nash, R. J. (2001). Polyhydroxylated alkaloids - natural occurrence and therapeutic applications. Phytochemistry, 56, 265-295

PY - 2001/2/21

Y1 - 2001/2/21

N2 - Over one hundred polyhydroxylated alkaloids have been isolated from plants and micro-organisms. These alkaloids can be potent and highly selective glycosidase inhibitors and are arousing great interest as tools to study cellular recognition and as potential therapeutic agents. However, only three of the natural products so far have been widely studied for therapeutic potential due largely to the limited commercial availability of the other compounds.

AB - Over one hundred polyhydroxylated alkaloids have been isolated from plants and micro-organisms. These alkaloids can be potent and highly selective glycosidase inhibitors and are arousing great interest as tools to study cellular recognition and as potential therapeutic agents. However, only three of the natural products so far have been widely studied for therapeutic potential due largely to the limited commercial availability of the other compounds.

KW - Glycosidase

KW - Indolizidines

KW - Inhibitors

KW - N-Containing sugars

KW - Nortropanes

KW - Piperidines

KW - Pyrrolidines

KW - Pyrrolizidines

UR - https://www.scopus.com/pages/publications/0035925104

U2 - 10.1016/S0031-9422(00)00451-9

DO - 10.1016/S0031-9422(00)00451-9

M3 - Article

SN - 0031-9422

VL - 56

SP - 265

EP - 295

JO - Phytochemistry

JF - Phytochemistry

IS - 3

ER -

Polyhydroxylated alkaloids - natural occurrence and therapeutic applications

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