Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles

Moses Egesa; Karl Hoffmann; Cornelis H. Hokke; Maria Yazdanbakhsh; Stephen Cose

doi:10.1016/j.pt.2017.07.007

Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles

Moses Egesa, Karl Hoffmann, Cornelis H. Hokke, Maria Yazdanbakhsh, Stephen Cose

Adran y Gwyddorau Bywyd

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

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260 Wedi eu Llwytho i Lawr (Pure)

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There is currently no vaccine against schistosomiasis. With few Schistosoma vaccine candidates in clinical trials, unexplored antigens from the vulnerable schistosomulum should be considered as possible vaccine candidates. In addition, we suggest developing synthetic vesicles as a new delivery vehicle and adjuvant for immunoprophylactic schistosomula vaccine candidates.

Iaith wreiddiol	Saesneg
Rhif yr erthygl	1671
Tudalennau (o-i)	918-921
Nifer y tudalennau	4
Cyfnodolyn	Trends in Parasitology
Cyfrol	33
Rhif cyhoeddi	12
Dyddiad ar-lein cynnar	14 Awst 2017
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1016/j.pt.2017.07.007
Statws	Cyhoeddwyd - 01 Rhag 2017

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10.1016/j.pt.2017.07.007

Rethinking Schistosomiasis Vaccine Development: Synthetic VesiclesLlawysgrif awdur wedi’i dderbyn, 1.05 MB

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@article{9f166620accb4eaa9afe7b91eea42c0f,

title = "Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles",

abstract = "There is currently no vaccine against schistosomiasis. With few Schistosoma vaccine candidates in clinical trials, unexplored antigens from the vulnerable schistosomulum should be considered as possible vaccine candidates. In addition, we suggest developing synthetic vesicles as a new delivery vehicle and adjuvant for immunoprophylactic schistosomula vaccine candidates.",

keywords = "Schistosoma, adjuvant, delivery, schistosomula, synthetic vesicles, vaccine candidates, Schistosoma mansoni/metabolism, Schistosomiasis/prevention & control, Animals, Vaccines/administration & dosage, Humans, Antigens, Helminth/immunology",

author = "Moses Egesa and Karl Hoffmann and Hokke, {Cornelis H.} and Maria Yazdanbakhsh and Stephen Cose",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

month = dec,

day = "1",

doi = "10.1016/j.pt.2017.07.007",

language = "English",

volume = "33",

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T1 - Rethinking Schistosomiasis Vaccine Development

T2 - Synthetic Vesicles

AU - Egesa, Moses

AU - Hoffmann, Karl

AU - Hokke, Cornelis H.

AU - Yazdanbakhsh, Maria

AU - Cose, Stephen

PY - 2017/12/1

Y1 - 2017/12/1

N2 - There is currently no vaccine against schistosomiasis. With few Schistosoma vaccine candidates in clinical trials, unexplored antigens from the vulnerable schistosomulum should be considered as possible vaccine candidates. In addition, we suggest developing synthetic vesicles as a new delivery vehicle and adjuvant for immunoprophylactic schistosomula vaccine candidates.

AB - There is currently no vaccine against schistosomiasis. With few Schistosoma vaccine candidates in clinical trials, unexplored antigens from the vulnerable schistosomulum should be considered as possible vaccine candidates. In addition, we suggest developing synthetic vesicles as a new delivery vehicle and adjuvant for immunoprophylactic schistosomula vaccine candidates.

KW - Schistosoma

KW - adjuvant

KW - delivery

KW - schistosomula

KW - synthetic vesicles

KW - vaccine candidates

KW - Schistosoma mansoni/metabolism

KW - Schistosomiasis/prevention & control

KW - Animals

KW - Vaccines/administration & dosage

KW - Humans

KW - Antigens, Helminth/immunology

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JO - Trends in Parasitology

JF - Trends in Parasitology

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Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles

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