RNA encoding the MPT83 antigen induces protective immune responses against Mycobacterium tuberculosis infection

Tian Xue, Evangelos Stavropoulos, Min Yang, Silvia Ragno, Martin Vordermeier, Mark Chambers, Glyn Hewinson, Douglas B. Lowrie, M. Joseph Colston, Ricardo E. Tascon*

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

61 Dyfyniadau (Scopus)

Crynodeb

We have previously demonstrated that vaccination of mice with plasmid DNA vectors expressing immunodominant mycobacterial genes induced cellular immune responses and significant protection against challenge with Mycobacterium tuberculosis. We demonstrate here, using in vitro-synthesized RNA, that vaccination with DNA or RNA constructs expressing the M. tuberculosis MPT83 antigen are capable of inducing specific humoral and T-cell immune responses and confer modest but significant protection against M. tuberculosis challenge in mice. This is the first report of protective immunity conferred against intracellular bacteria by an RNA vaccine. This novel approach avoids some of the drawbacks of DNA vaccines and illustrates the potential for developing new antimycobacterial immunization strategies.

Iaith wreiddiolSaesneg
Tudalennau (o-i)6324-6329
Nifer y tudalennau6
CyfnodolynInfection and Immunity
Cyfrol72
Rhif cyhoeddi11
Dyddiad ar-lein cynnar21 Hyd 2004
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 01 Tach 2004

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