Schistosoma mansoni venom allergen-like proteins: Phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity

Leonardo P. Farias, Iain W Chalmers, Samirah Perally, Henrique K. Rofatto, Colin J. Jackson, Martha Brown, Mariana I. Khouri, Mayra M. F. Barbosa, Paul J. Hensbergen, Cornelis H. Hokke, Luciana C. C. Leite, Karl F Hoffmann

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

8 Dyfyniadau(SciVal)
171 Wedi eu Llwytho i Lawr (Pure)

Crynodeb

Schistosoma mansoni venom allergen-like proteins (SmVALs) are part of a diverse protein superfamily partitioned into two groups (group 1 and group 2). Phylogenetic analyses of group 1 SmVALs revealed that members could be segregated into subclades (A-D); these subclades share similar gene expression patterns across the parasite lifecycle and immunological cross-reactivity. Furthermore, whole-mount in situ hybridization demonstrated that the phylogenetically, transcriptionally and immunologically-related SmVAL4, 10, 18 and 19 (subclade C) were all localized to the pre-acetabular glands of immature cercariae. Our results suggest that SmVAL group 1 phylogenetic relationships, stage-specific transcriptional profiles and tissue localization are predictive of immunological cross-reactivity.

Iaith wreiddiolSaesneg
Tudalennau (o-i)593-599
Nifer y tudalennau7
CyfnodolynInternational Journal for Parasitology
Cyfrol49
Rhif cyhoeddi8
Dyddiad ar-lein cynnar25 Mai 2019
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 01 Gorff 2019

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Gweld gwybodaeth am bynciau ymchwil 'Schistosoma mansoni venom allergen-like proteins: Phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity'. Gyda’i gilydd, maen nhw’n ffurfio ôl bys unigryw.

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